Jaenisch, Rudolf

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

Soldner, F., Laganière, J., Cheng, A. W., Hockemeyer, D., Gao, Q., Alagappan, R., Khurana, V., Golbe, L. I., Myers, R. H., Lindquist, S., et al. (2011) · Cell

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 728

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., et al. (2001) · Nature Genetics

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 694

Efficient derivation of microglia-like cells from human pluripotent stem cells

Muffat, J., Li, Y., Yuan, B., Mitalipova, M., Omer, A., Corcoran, S., Bakiasi, G., Tsai, L.-H., Aubourg, P., Ransohoff, R. M., et al. (2016) · Nature Medicine

Pluripotent Stem Cells ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 651

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett Syndrome

Dani, V. S., Chang, Q., Maffei, A., Turrigiano, G. G., Jaenisch, R., & Nelson, S. B. (2005) · Proceedings of the National Academy of Sciences

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 639

Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development

Liu, X., Wu, H., Byrne, M., Krane, S., & Jaenisch, R. (1997) · Proceedings of the National Academy of Sciences

Connective tissue disorders researchCollagen: Extraction and Characterization

Cited by 614

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

Tropea, D., Giacometti, E., Wilson, N. R., Beard, C., McCurry, C., Fu, D. D., Flannery, R., Jaenisch, R., & Sur, M. (2009) · Proceedings of the National Academy of Sciences

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 593

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

Foudi, A., Hochedlinger, K., Van Buren, D., Schindler, J. W., Jaenisch, R., Carey, V., & Hock, H. (2009) · Nature Biotechnology

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 586

The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression

Chang, Q., Khare, G., Dani, V., Nelson, S., & Jaenisch, R. (2006) · Neuron

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 578

Functional analysis of activins during mammalian development

Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., & Bradley, A. (1995) · Nature

Developmental Biology and Gene RegulationCleft Lip and Palate Research

Cited by 578

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development

Dawlaty, M. M., Ganz, K., Powell, B. E., Hu, Y.-C., Markoulaki, S., Cheng, A. W., Gao, Q., Kim, J., Choi, S.-W., Page, D. C., et al. (2011) · Cell stem cell

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 508

Induced Pluripotent Stem Cells Meet Genome Editing

Hockemeyer, D., & Jaenisch, R. (2016) · Cell Stem Cell

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 499

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

Bröske, A.-M., Vockentanz, L., Kharazi, S., Huska, M. R., Mancini, E., Scheller, M., Kuhl, C., Enns, A., Prinz, M., Jaenisch, R., et al. (2009) · Nature Genetics

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 478

Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells

Guenther, M. G., Frampton, G. M., Soldner, F., Hockemeyer, D., Mitalipova, M., Jaenisch, R., & Young, R. A. (2010) · Cell Stem Cell

Pluripotent Stem Cells ResearchGenomics and Chromatin Dynamics

Cited by 456

Induction of Expansion and Folding in Human Cerebral Organoids

Li, Y., Muffat, J., Omer, A., Bosch, I., Lancaster, M. A., Sur, M., Gehrke, L., Knoblich, J. A., & Jaenisch, R. (2017) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsFetal and Pediatric Neurological Disorders

Cited by 436

Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease

Saha, K., & Jaenisch, R. (2009) · Cell Stem Cell

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 411

3D Chromosome Regulatory Landscape of Human Pluripotent Cells

Ji, X., Dadon, D. B., Powell, B. E., Fan, Z. P., Borges-Rivera, D., Shachar, S., Weintraub, A. S., Hnisz, D., Pegoraro, G., Lee, T. I., et al. (2016) · Cell Stem Cell

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 400

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

Dawlaty, M. M., Breiling, A., Le, T., Barrasa, M. I., Raddatz, G., Gao, Q., Powell, B. E., Cheng, A. W., Faull, K. F., Lyko, F., et al. (2014) · Developmental Cell

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 338

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

Dettmer, U., Newman, A. J., Soldner, F., Luth, E. S., Kim, N. C., von Saucken, V. E., Sanderson, J. B., Jaenisch, R., Bartels, T., & Selkoe, D. (2015) · Nature Communications

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 317

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

Fanning, S., Haque, A., Imberdis, T., Baru, V., Barrasa, M. I., Nuber, S., Termine, D., Ramalingam, N., Ho, G. P. H., Noble, T., et al. (2019) · Molecular Cell

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 285

Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2

Giacometti, E., Luikenhuis, S., Beard, C., & Jaenisch, R. (2007) · Proceedings of the National Academy of Sciences

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 271

Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells

Maetzel, D., Sarkar, S., Wang, H., Abi-Mosleh, L., Xu, P., Cheng, A. W., Gao, Q., Mitalipova, M., & Jaenisch, R. (2014) · Stem Cell Reports

Lysosomal Storage Disorders ResearchGlycogen Storage Diseases and Myoclonus

Cited by 195

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

Welstead, G. G., Creyghton, M. P., Bilodeau, S., Cheng, A. W., Markoulaki, S., Young, R. A., & Jaenisch, R. (2012) · Proceedings of the National Academy of Sciences

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 194

Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background

Lombard, D. B., Beard, C., Johnson, B., Marciniak, R. A., Dausman, J., Bronson, R., Buhlmann, J. E., Lipman, R., Curry, R., Sharpe, A., et al. (2000) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 187

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases

Trapecar, M., Wogram, E., Svoboda, D., Communal, C., Omer, A., Lungjangwa, T., Sphabmixay, P., Velazquez, J., Schneider, K., Wright, C. W., et al. (2021) · Science Advances

3D Printing in Biomedical ResearchPluripotent Stem Cells Research

Cited by 176