Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143 · see citing works

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836 · see citing works

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984 · see citing works

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451 · see citing works

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

He, Y., Li, B.-Z., Li, Z., Liu, P., Wang, Y., Tang, Q., Ding, J., Jia, Y., Chen, Z., Li, L., et al. (2011) · Science · doi:10.1126/science.1210944 · Cited by 2,776 · see citing works

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700 · see citing works

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

Wernig, M., Meissner, A., Foreman, R. K., Brambrink, T., Ku, M., Hochedlinger, K., Bernstein, B., & Jaenisch, R. (2007) · Nature · doi:10.1038/nature05944 · Cited by 2,654 · see citing works

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Ito, S., D’Alessio, A. C., Taranova, O., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,542 · see citing works

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.001 · Cited by 1,339 · see citing works

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

Gu, T., Guo, F., Yang, H., Wu, H.-P., Xu, G., Liu, W., Xie, Z.-G., Shi, L., He, X., Jin, S., et al. (2011) · Nature · doi:10.1038/nature10443 · Cited by 1,144 · see citing works

Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

Wu, H., & Zhang, Y. (2014) · Cell · doi:10.1016/j.cell.2013.12.019 · Cited by 1,065 · see citing works

Active DNA demethylation: many roads lead to Rome

Wu, S. C., & Zhang, Y. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2950 · Cited by 1,054 · see citing works

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J., & Helin, K. (2011) · Nature · doi:10.1038/nature10066 · Cited by 1,021 · see citing works

A unique regulatory phase of DNA methylation in the early mammalian embryo

Smith, Z. D., Chan, M. M., Mikkelsen, T. S., Gu, H., Gnirke, A., Regev, A., & Meissner, A. (2012) · Nature · doi:10.1038/nature10960 · Cited by 964 · see citing works

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

Lei, H., Oh, S. P., Okano, M., Jüttermann, R., Goss, K. A., Jaenisch, R., & Li, E. (1996) · Development · doi:10.1242/dev.122.10.3195 · Cited by 816 · see citing works

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

Pastor, W. A., Pape, U. J., Huang, Y., Henderson, H. R., Lister, R., Ko, M., McLoughlin, E. M., Brudno, Y., Mahapatra, S., Kapranov, P., et al. (2011) · Nature · doi:10.1038/nature10102 · Cited by 804 · see citing works

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

Wossidlo, M., Nakamura, T., Lepikhov, K., Marques, C. J., Zakhartchenko, V., Boiani, M., Arand, J., Nakano, T., Reik, W., & Walter, J. (2011) · Nature Communications · doi:10.1038/ncomms1240 · Cited by 793 · see citing works

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

Koh, K. P., Yabuuchi, A., Rao, S., Huang, Y., Cunniff, K., Nardone, J., Laiho, A., Tahiliani, M., Sommer, C. A., Mostoslavsky, G., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.01.008 · Cited by 776 · see citing works

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells

Xie, W., Schultz, M. D., Lister, R., Hou, Z., Rajagopal, N., Ray, P. R., Whitaker, J. W., Tian, S., Hawkins, R. D., Leung, D., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.022 · Cited by 721 · see citing works

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

Li, Z., Cai, X., Cai, C.-L., Wang, J., Zhang, W., Petersen, B. E., Yang, F.-C., & Xu, M. (2011) · Blood · doi:10.1182/blood-2010-12-325241 · Cited by 671 · see citing works

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development

Dawlaty, M. M., Ganz, K., Powell, B. E., Hu, Y.-C., Markoulaki, S., Cheng, A. W., Gao, Q., Kim, J., Choi, S.-W., Page, D. C., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.010 · Cited by 508 · see citing works

Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair Pathway

Hájková, P., Jeffries, S. J., Lee, C. G. L., Miller, N. G. A., Jackson, S. P., & Surani, M. A. (2010) · Science · doi:10.1126/science.1187945 · Cited by 473 · see citing works

5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

Stroud, H., Feng, S., Kinney, S. R. M., Pradhan, S., & Jacobsen, S. E. (2011) · Genome biology · doi:10.1186/gb-2011-12-6-r54 · Cited by 466 · see citing works

Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells

Gifford, C. A., Ziller, M. J., Gu, H., Trapnell, C., Donaghey, J., Tsankov, A., Shalek, A. K., Kelley, D. R., Shishkin, A. A., Issner, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.037 · Cited by 435 · see citing works

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

Dawlaty, M. M., Breiling, A., Le, T. T., Raddatz, G., Barrasa, M. I., Cheng, A. W., Gao, Q., Powell, B. E., Li, Z., Xu, M., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2012.12.015 · Cited by 431 · see citing works

DNA hypomethylation can activate Xist expression and silence X-linked genes.Preprint

Panning, B., & Jaenisch, R. (1996) · Genes & Development · doi:10.1101/gad.10.16.1991 · Cited by 371 · see citing works

Methylome analysis using MeDIP-seq with low DNA concentrations

Taiwo, O., Wilson, G. A., Morris, T. J., Seisenberger, S., Reik, W., Pearce, D., Beck, S., & Butcher, L. M. (2012) · Nature Protocols · doi:10.1038/nprot.2012.012 · Cited by 294 · see citing works

Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin

Grönniger, E., Weber, B., Heil, O., Peters, N., Stäb, F., Wenck, H., Korn, B., Winnefeld, M., & Lyko, F. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000971 · Cited by 275 · see citing works

Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells

Huang, Y., Chávez, L., Chang, X., Wang, X., Pastor, W. A., Kang, J., Zepeda-Martínez, J. A., Pape, U. J., Jacobsen, S. E., Peters, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322921111 · Cited by 258 · see citing works

A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples

Le, T. T., Kim, K.-P., Fan, G., & Faull, K. F. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.01.026 · Cited by 153 · see citing works

Synergistic Mechanisms of DNA Demethylation during Transition to Ground-State Pluripotency

Hackett, J. A., Dietmann, S., Murakami, K., Down, T. A., Leitch, H. G., & Surani, M. A. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.11.010 · Cited by 124 · see citing works

DNA Methylation Is Dispensable for the Growth and Survival of the Extraembryonic Lineages

Sakaue, M., Ohta, H., Kumaki, Y., Oda, M., Sakaide, Y., Matsuoka, C., Yamagiwa, A., Niwa, H., Wakayama, T., & Okano, M. (2010) · Current Biology · doi:10.1016/j.cub.2010.06.050 · Cited by 118 · see citing works

Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster

Bocker, M., Tuorto, F., Raddatz, G., Musch, T., Yang, F., Xu, M., Lyko, F., & Breiling, A. (2012) · Nature Communications · doi:10.1038/ncomms1826 · Cited by 72 · see citing works

TET-mediated active DNA demethylation: mechanism, function and beyond

Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661 · see citing works

Role of TET enzymes in DNA methylation, development, and cancer

Rasmussen, K. D., & Helin, K. (2016) · Genes & Development · doi:10.1101/gad.276568.115 · Cited by 1,040 · see citing works

The interplay of epigenetic marks during stem cell differentiation and development

Atlasi, Y., & Stunnenberg, H. G. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.57 · Cited by 569 · see citing works

Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond

Breiling, A., & Lyko, F. (2015) · Epigenetics & Chromatin · doi:10.1186/s13072-015-0016-6 · Cited by 353 · see citing works

5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation

Hon, G. C., Song, C., Du, T., Jin, F., Selvaraj, S., Lee, A. Y., Yen, C., Ye, Z., Mao, S.-Q., Wang, B.-A., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.026 · Cited by 332 · see citing works

Epigenetic control of myeloid cell differentiation, identity and function

Álvarez‐Errico, D., Vento‐Tormo, R., Sieweke, M. H., & Ballestar, E. (2014) · Nature reviews. Immunology · doi:10.1038/nri3777 · Cited by 328 · see citing works

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells

TeSlaa, T., Chaikovsky, A. C., Lipchina, I., Escobar, S. L., Hochedlinger, K., Huang, J., Graeber, T. G., Braas, D., & Teitell, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.002 · Cited by 287 · see citing works

Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond

Kumar, S., Chinnusamy, V., & Mohapatra, T. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00640 · Cited by 287 · see citing works

Epigenetic responses and the developmental origins of health and disease

Goyal, D., Limesand, S. W., & Goyal, R. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0009 · Cited by 289 · see citing works

Role of Tet proteins in enhancer activity and telomere elongationPreprint

Lu, F., Liu, Y., Jiang, L., Yamaguchi, S., & Zhang, Y. (2014) · Genes & Development · doi:10.1101/gad.248005.114 · Cited by 269 · see citing works

Common stemness regulators of embryonic and cancer stem cells

Hadjimichael, C. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i9.1150 · Cited by 246 · see citing works

Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism

Weber, A. R., Krawczyk, C., Robertson, A. B., Kuśnierczyk, A., Vågbø, C. B., Schuermann, D., Klungland, A., & Schär, P. (2016) · Nature Communications · doi:10.1038/ncomms10806 · Cited by 233 · see citing works

TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling

Dai, H.-Q., Wang, B.-A., Yang, L., Chen, J.-J., Zhu, G.-C., Sun, M.-L., Ge, H., Wang, R., Chapman, D. L., Tang, F., et al. (2016) · Nature · doi:10.1038/nature20095 · Cited by 206 · see citing works

Active turnover of DNA methylation during cell fate decisions

Parry, A., Rulands, S., & Reik, W. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-00287-8 · Cited by 214 · see citing works

The microbiota programs DNA methylation to control intestinal homeostasis and inflammation

Ansari, I., Raddatz, G., Gutekunst, J., Ridnik, M., Cohen, D., Abu-Remaileh, M., Tuganbaev, T., Shapiro, H., Pikarsky, E., Elinav, E., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-019-0659-3 · Cited by 202 · see citing works

TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells

Verma, N., Pan, H., Doré, L. C., Shukla, A., Li, Q. V., Pelham‐Webb, B., Teijeiro, V., Gonzãlez, F., Krivtsov, A. V., Chang, C.-J., et al. (2017) · Nature Genetics · doi:10.1038/s41588-017-0002-y · Cited by 196 · see citing works

5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability

Kafer, G. R., Li, X., Horii, T., Suetake, I., Tajima, S., Hatada, I., & Carlton, P. M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.035 · Cited by 197 · see citing works

Gestational Hypoxia and Developmental Plasticity

Ducsay, C. A., Goyal, R., Pearce, W. J., Wilson, S. M., Hu, X., & Zhang, L. (2018) · Physiological Reviews · doi:10.1152/physrev.00043.2017 · Cited by 203 · see citing works

Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAsPreprint

Legrand, C., Tuorto, F., Hartmann, M., Liebers, R., Jacob, D., Helm, M., & Lyko, F. (2017) · Genome Research · doi:10.1101/gr.210666.116 · Cited by 196 · see citing works

Sexual-lineage-specific DNA methylation regulates meiosis in Arabidopsis

Walker, J., Gao, H., Zhang, J., Aldridge, B., Vickers, M. J., Higgins, J. D., & Feng, X. (2017) · Nature Genetics · doi:10.1038/s41588-017-0008-5 · Cited by 190 · see citing works

Ontogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse

Auclair, G., Guibert, S., Bender, A., & Weber, M. (2014) · Genome biology · doi:10.1186/s13059-014-0545-5 · Cited by 189 · see citing works

Dynamics and Context-Dependent Roles of DNA Methylation

Ambrosi, C. M., Manzo, M., & Baubec, T. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.02.008 · Cited by 184 · see citing works

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Bhagat, T. D., Ahrens, D. V., Dawlaty, M. M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., et al. (2019) · eLife · doi:10.7554/elife.50663 · Cited by 170 · see citing works

A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity

Ginno, P. A., Gaidatzis, D., Feldmann, A., Hoerner, L., Imanci, D., Burger, L., Zilbermann, F., Peters, A. H. F. M., Edenhofer, F., Smallwood, S. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16354-x · Cited by 171 · see citing works

DNA demethylation pathways: Additional players and regulators

Bochtler, M., Kolano, A., & Xu, G. (2016) · BioEssays · doi:10.1002/bies.201600178 · Cited by 172 · see citing works

Mechanisms that regulate the activities of TET proteins

Joshi, K., Liu, S., Breslin, P., & Zhang, J. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04396-x · Cited by 172 · see citing works

DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells

Gu, T., Lin, X., Cullen, S. M., Luo, M., Jeong, M., Estecio, M. R., Shen, J., Hardikar, S., Sun, D., Su, J., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1464-7 · Cited by 157 · see citing works

Molecular Mechanisms Underlying the Link between Diet and DNA Methylation

Kadayıfçı, F. Z., Zheng, S., & Pan, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124055 · Cited by 139 · see citing works

A Metabolic Roadmap for Somatic Stem Cell Fate

Ly, C., Lynch, G. S., & Ryall, J. G. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.022 · Cited by 138 · see citing works

Chromatin Control of Developmental Dynamics and Plasticity

Perino, M., & Veenstra, G. J. C. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.08.004 · Cited by 131 · see citing works

Loss of 5-hydroxymethylcytosine in cancer: Cause or consequence?

Ficz, G., & Gribben, J. G. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.017 · Cited by 132 · see citing works

Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis

Kang, J., Lienhard, M., Pastor, W. A., Chawla, A., Novotny, M., Tsagaratou, A., Lasken, R. S., Thompson, E. C., Surani, M. A., Koralov, S. B., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510510112 · Cited by 126 · see citing works

5-Hydroxymethylcytosine: A stable or transient DNA modification?

Hahn, M. A., Szabó, P. E., & Pfeifer, G. P. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.015 · Cited by 127 · see citing works

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

D’Aniello, C., Cermola, F., Patriarca, E. J., & Minchiotti, G. (2017) · Stem Cells International · doi:10.1155/2017/8936156 · Cited by 132 · see citing works

Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory

Gomez, D. A., Swiatlowska, P., & Owens, G. K. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305044 · Cited by 121 · see citing works

G9a/GLP Complex Maintains Imprinted DNA Methylation in Embryonic Stem Cells

Zhang, T., Termanis, A., Özkan, B., Bao, X. X., Culley, J., Alves, F. D. L., Rappsilber, J., Ramsahoye, B. H., & Stancheva, I. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.007 · Cited by 122 · see citing works

Mapping and elucidating the function of modified bases in DNA

Raiber, E., Hardisty, R. E., van Delft, P., & Balasubramanian, S. (2017) · Nature Reviews Chemistry · doi:10.1038/s41570-017-0069 · Cited by 117 · see citing works

5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy

Vasanthakumar, A., & Godley, L. A. (2015) · Cancer Genetics · doi:10.1016/j.cancergen.2015.02.009 · Cited by 114 · see citing works

DNA methylation dynamics in cellular commitment and differentiation

Suelves, M., Carrió, E., Núñez‐Álvarez, Y., & Peinado, M. A. (2016) · Briefings in Functional Genomics · doi:10.1093/bfgp/elw017 · Cited by 114 · see citing works

Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance

Wang, Q., Yu, G., Ming, X., Xia, W., Xu, X., Zhang, Y., Zhang, W., Li, Y., Huang, C., Xie, H., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0661-y · Cited by 113 · see citing works

OGG1 is essential in oxidative stress induced DNA demethylation

Zhou, X.-L., Zhuang, Z., Wang, W., He, L., Wu, H., Cao, Y., Pan, F., Zhao, J., Hu, Z., Sekhar, C., et al. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.05.021 · Cited by 112 · see citing works

A developmental framework for induced pluripotency

Takahashi, K., & Yamanaka, S. (2015) · Development · doi:10.1242/dev.114249 · Cited by 111 · see citing works

Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency

Schlesinger, S., & Meshorer, E. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.003 · Cited by 104 · see citing works

Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children’s Health Study

Breton, C. V., Yao, J., Millstein, J., Gao, L., Siegmund, K. D., Mack, W. J., Whitfield, L., Lurmann, F. W., Hodis, H. N., Avol, E., et al. (2016) · Environmental Health Perspectives · doi:10.1289/ehp181 · Cited by 109 · see citing works

Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development

Zhang, W., Xia, W., Wang, Q., Towers, A. J., Chen, J., Gao, R., Zhang, Y., Yen, C., Lee, A. Y., Li, Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.030 · Cited by 109 · see citing works

The Genomic Impact of DNA CpG Methylation on Gene Expression; Relationships in Prostate Cancer

Long, M. D., Smiraglia, D. J., & Campbell, M. J. (2017) · Biomolecules · doi:10.3390/biom7010015 · Cited by 108 · see citing works

QSER1 protects DNA methylation valleys from de novo methylation

Dixon, G., Pan, H., Yang, D., Rosen, B. P., Jashari, T., Verma, N., Pulecio, J., Caspi, I., Lee, K., Stransky, S., et al. (2021) · Science · doi:10.1126/science.abd0875 · Cited by 108 · see citing works

Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation

Kapellos, T. S., & Iqbal, A. J. (2016) · Mediators of Inflammation · doi:10.1155/2016/6591703 · Cited by 104 · see citing works

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function

Orlanski, S., Labi, V., Reizel, Y., Spiro, A., Lichtenstein, M., Levin-Klein, R., Koralov, S. B., Skversky‐Blocq, Y., Rajewsky, K., Cedar, H., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604365113 · Cited by 103 · see citing works

The role of α-ketoglutarate–dependent proteins in pluripotency acquisition and maintenance

Tran, K. A., Dillingham, C. M., & Sridharan, R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.000831 · Cited by 104 · see citing works

A reassessment of DNA-immunoprecipitation-based genomic profiling

Lentini, A., Lagerwall, C., Vikingsson, S., Mjoseng, H. K., Douvlataniotis, K., Vogt, H., Gréen, H., Meehan, R. R., Benson, M., & Nestor, C. E. (2018) · Nature Methods · doi:10.1038/s41592-018-0038-7 · Cited by 100 · see citing works

TET enzymes and DNA hydroxymethylation in neural development and function — How critical are they?

Santiago, M., Antunes, C., Guedes, M., Sousa, N., & Marques, C. J. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.018 · Cited by 98 · see citing works

Vitamin C – A new player in regulation of the cancer epigenome

Gillberg, L., Ørskov, A. D., Liu, M., Harsløf, L. B. S., Jones, P. A., & Grønbæk, K. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.001 · Cited by 100 · see citing works

Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling

Li, X., Yue, X., Pastor, W. A., Lin, L., Georges, R. O., Chávez, L., Evans, S. Μ., & Rao, A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617802113 · Cited by 98 · see citing works

Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming

Ding, J., Huang, X., Shao, N., Zhou, H., Lee, D., Faiola, F., Fidalgo, M., Guallar, D., Saunders, A., Shliaha, P. V., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.04.001 · Cited by 93 · see citing works

Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States

Fidalgo, M., Huang, X., Guallar, D., Sánchez-Priego, C., Valdés, V. J., Saunders, A., Ding, J., Wu, W.-S., Clavel, C., & Wang, J. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.05.025 · Cited by 94 · see citing works

Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine

Klungland, A., & Robertson, A. B. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.038 · Cited by 95 · see citing works

TET enzymes, DNA demethylation and pluripotency

Ross, S. E., & Bogdanović, O. (2019) · Biochemical Society Transactions · doi:10.1042/bst20180606 · Cited by 91 · see citing works

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation

Schomacher, L., Han, D., Musheev, M. U., Arab, K., Kienhöfer, S., von Seggern, A., & Niehrs, C. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3151 · Cited by 85 · see citing works

The Roles of DNA Methylation in the Stages of Cancer

McMahon, K. W., Karunasena, E., & Ahuja, N. (2017) · The Cancer Journal · doi:10.1097/ppo.0000000000000279 · Cited by 87 · see citing works

TET2 chemically modifies tRNAs and regulates tRNA fragment levels

He, C., Bozler, J., Janssen, K. A., Wilusz, J. E., Garcia, B. A., Schorn, A. J., & Bonasio, R. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-00526-w · Cited by 87 · see citing works

ATAC-Me Captures Prolonged DNA Methylation of Dynamic Chromatin Accessibility Loci during Cell Fate Transitions

Barnett, K. R., Decato, B. E., Scott, T. J., Hansen, T. J., Chen, B., Attalla, J., Smith, A. D., & Hodges, E. C. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.01.004 · Cited by 84 · see citing works

Active DNA demethylation by DNA repair: Facts and uncertainties

Schuermann, D., Weber, A. R., & Schär, P. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.013 · Cited by 82 · see citing works

Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development

Fang, S.-H., Li, J., Xiao, Y., Lee, M., Guo, L., Han, W., Li, T., Hill, M. C., Hong, T.-T., Mo, W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12325-z · Cited by 70 · see citing works

Postnatal DNA demethylation and its role in tissue maturation

Reizel, Y., Sabag, O., Skversky, Y., Spiro, A., Steinberg, B., Bernstein, D., Wang, A., Kieckhaefer, J., Li, C., Pikarsky, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04456-6 · Cited by 83 · see citing works

Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

Song, Y., van den Berg, P. R., Markoulaki, S., Soldner, F., Dall’Agnese, A., Henninger, J. E., Drotar, J., Rosenau, N., Cohen, M. A., Young, R. A., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.06.045 · Cited by 84 · see citing works

Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination

Cakouros, D., Hemming, S., Gronthos, K., Liu, R., Zannettino, A. C. W., Shi, S., & Gronthos, S. (2019) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0247-4 · Cited by 81 · see citing works

Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs

Yang, J., Guo, R., Wang, H., Ye, X., Zhou, Z., Dan, J., Wang, H., Gong, P., Deng, W. W., Yin, Y., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.058 · Cited by 81 · see citing works

Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence

Li, C., Lan, Y., Schwartz-Orbach, L., Korol, E., Tahiliani, M., Evans, T., & Goll, M. G. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.025 · Cited by 80 · see citing works

The roles of TET family proteins in development and stem cells

Yang, J., Bashkenova, N., Zang, R., Huang, X., & Wang, J. (2020) · Development · doi:10.1242/dev.183129 · Cited by 80 · see citing works

Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation

Lan, J., Rajan, N., Bizet, M., Penning, A., Singh, N. K., Guallar, D., Calonne, E., Greci, A. L., Bonvin, E., Deplus, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18729-6 · Cited by 75 · see citing works

5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo

Iwan, K., Rahimoff, R., Kirchner, A., Spada, F., Schröder, A. S., Kosmatchev, O., Ferizaj, S., Steinbacher, J., Parsa, E., Müller, M., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2531 · Cited by 77 · see citing works

Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells

Takahashi, Y., Wu, J., Suzuki, K., Martínez‐Redondo, P., Li, M., Liao, H.-K., Wu, M.-Z., Hernández‐Benítez, R., Hishida, T., Shokhirev, M. N., et al. (2017) · Science · doi:10.1126/science.aag3260 · Cited by 77 · see citing works

Hepatocyte Nuclear Factor 4‐Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver

Thakur, A., Wong, J. C. H., Wang, E. Y., Lotto, J., Kim, D., Cheng, J., Mingay, M., Cullum, R., Moudgil, V., Ahmed, N., et al. (2019) · Hepatology · doi:10.1002/hep.30631 · Cited by 75 · see citing works

Epigenetic control of transcriptional regulation in pluripotency and early differentiation

Gökbuget, D., & Blelloch, R. H. (2019) · Development · doi:10.1242/dev.164772 · Cited by 69 · see citing works

Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis by modulating cell-extrinsic signaling pathways

Seritrakul, P., & Gross, J. M. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006987 · Cited by 72 · see citing works

Transcription Factors That Govern Development and Disease: An Achilles Heel in Cancer

Huilgol, D., Venkataramani, P., Nandi, S., & Bhattacharjee, S. (2019) · Genes · doi:10.3390/genes10100794 · Cited by 70 · see citing works

Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells

Gonzales-Cope, M., Sidoli, S., Bhanu, N. V., Won, K., & Garcia, B. A. (2016) · BMC Genomics · doi:10.1186/s12864-016-2414-y · Cited by 70 · see citing works

TET Family of Dioxygenases: Crucial Roles and Underlying Mechanisms

Li, D., Guo, B., Wu, H., Tan, L., & Lu, Q. (2015) · Cytogenetic and Genome Research · doi:10.1159/000438853 · Cited by 68 · see citing works

DNA Modification Readers and Writers and Their Interplay

Rausch, C., Hastert, F. D., & Cardoso, M. C. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.018 · Cited by 67 · see citing works

DNA methylation dynamics in muscle development and disease

Carrió, E., & Suelves, M. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00019 · Cited by 62 · see citing works

DNA-Methylation: Master or Slave of Neural Fate Decisions?

Stricker, S. H., & Götz, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00005 · Cited by 64 · see citing works

Linking Telomere Regulation to Stem Cell Pluripotency

Liu, L. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.10.007 · Cited by 66 · see citing works

Low Shear Stress Inhibited Endothelial Cell Autophagy Through TET2 Downregulation

Yang, Q., Li, X., Li, R., Peng, J., Zuo, W., Jiang, Z., Tang, X., Zhao, P., Wang, Y., & Wei, D. (2015) · Annals of Biomedical Engineering · doi:10.1007/s10439-015-1491-4 · Cited by 66 · see citing works

The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity

Chrysanthou, S., Tang, Q., Lee, J., Taylor, S. J., Zhao, Y., Steidl, U. G., Zheng, D., & Dawlaty, M. M. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac089 · Cited by 64 · see citing works

Selective targeting of TET catalytic domain promotes somatic cell reprogramming

Singh, A. K., Zhao, B., Liu, X., Wang, X., Li, H., Qin, H., Wu, X., Ma, Y., Horne, D. A., & Yu, X. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910702117 · Cited by 63 · see citing works

A Therapeutic Strategy for Preferential Targeting of TET2-Mutant and TET Dioxygenase–Deficient Cells in Myeloid Neoplasms

Guan, Y., Tiwari, A. D., Phillips, J. G., Hasipek, M., Grabowski, D., Pagliuca, S., Gopal, P., Kerr, C. M., Ademà, V., Radivoyevitch, T., et al. (2020) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-20-0173 · Cited by 62 · see citing works

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

Hrit, J. A., Goodrich, L., Cheng, L., Wang, B.-A., Nie, J., Cui, X., Martin, E. A., Simental, E., Fernandez, J. A., Liu, M. Y., et al. (2018) · eLife · doi:10.7554/elife.34870 · Cited by 61 · see citing works

Epigenetic reprogramming of cell identity: lessons from development for regenerative medicine

Basu, A., & Tiwari, V. K. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01131-4 · Cited by 60 · see citing works

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling

Zhang, X., Li, S., He, J., Jin, Y., Zhang, R., Dong, W., Lin, M., Yang, Y., Tian, T., Zhou, Y., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3013 · Cited by 65 · see citing works

Physiological Alterations and Nondestructive Test Methods of Crop Seed Vigor: A Comprehensive Review

Xing, M., Long, Y., Wang, Q., Tian, X., Fan, S., Zhang, C., & Huang, W. (2023) · Agriculture · doi:10.3390/agriculture13030527 · Cited by 61 · see citing works

A primary role of TET proteins in establishment and maintenance ofDe Novobivalency at CpG islands

Kong, L., Tan, L., Lyu, R., Shi, Z., Xiong, L., Wu, F., Rabidou, K., Smith, M., He, C., Zhang, L., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw529 · Cited by 60 · see citing works

Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation

Wiehle, L., Raddatz, G., Musch, T., Dawlaty, M., Jaenisch, R., Lyko, F., & Breiling, A. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00587-15 · Cited by 55 · see citing works

Modeling complex patterns of differential DNA methylation that associate with gene expression changes

Schlosberg, C., VanderKraats, N. D., & Edwards, J. R. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx078 · Cited by 51 · see citing works

Arsenite Targets the Zinc Finger Domains of Tet Proteins and Inhibits Tet-Mediated Oxidation of 5-Methylcytosine

Liu, S., Jiang, J., Li, L., Amato, N. J., Wang, Z., & Wang, Y. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b03386 · Cited by 58 · see citing works

DNA Methylation and Recurrent Pregnancy Loss: A Mysterious Compass?

Zhou, Q., Xiong, Y., Qu, B., Bao, A., & Zhang, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.738962 · Cited by 56 · see citing works

TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells

Schoeler, K., Aufschnaiter, A., Messner, S., Derudder, E., Herzog, S., Villunger, A., Rajewsky, K., & Labi, V. (2019) · FEBS Journal · doi:10.1111/febs.14934 · Cited by 56 · see citing works

TET Enzymes and 5-Hydroxymethylcytosine in Neural Progenitor Cell Biology and Neurodevelopment

MacArthur, I. C., & Dawlaty, M. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645335 · Cited by 55 · see citing works

DNA methylation and hydroxymethylation in stem cells

Cheng, Y., Xie, N., Jin, P., & Wang, T. (2015) · Cell Biochemistry and Function · doi:10.1002/cbf.3101 · Cited by 55 · see citing works

New insights into mechanisms that regulate DNA methylation patterning

Ficz, G. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107961 · Cited by 54 · see citing works

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

Dawlaty, M. M., Breiling, A., Le, T. T., Raddatz, G., Barrasa, M. I., Cheng, A. W., Gao, Q., Powell, B. E., Li, Z., Xu, M., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2012.12.015 · Cited by 431 · see citing works

Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects

Wang, M., Wang, L., Huang, Y., Qiao, Z., Yi, S., Zhang, W., Wang, J., Yang, G., Cui, X., Kou, X., et al. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2631-x · Cited by 6 · see citing works

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development

Dawlaty, M. M., Ganz, K., Powell, B. E., Hu, Y.-C., Markoulaki, S., Cheng, A. W., Gao, Q., Kim, J., Choi, S.-W., Page, D. C., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.010 · Cited by 508 · see citing works

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

Koh, K. P., Yabuuchi, A., Rao, S., Huang, Y., Cunniff, K., Nardone, J., Laiho, A., Tahiliani, M., Sommer, C. A., Mostoslavsky, G., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.01.008 · Cited by 776 · see citing works

Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression

Reimer, M. H., Pulakanti, K., Shi, L., Abel, A. M., Liang, M., Malarkannan, S., & Rao, S. (2019) · BMC Developmental Biology · doi:10.1186/s12861-019-0196-6 · Cited by 13 · see citing works