Mayo, Lindsey D.

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

Mayo, L. D., & Donner, D. B. (2001) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 1,230

PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy

Mayo, L. D., Dixon, J. E., Durden, D. L., Tonks, N. K., & Donner, D. B. (2002) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 351

Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3

Patton, J. T., Mayo, L. D., Singhi, A. D., Gudkov, A. V., Stark, G. R., & Jackson, M. W. (2006) · Cancer Research

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 189

TGF-β1–induced expression of human Mdm2 correlates with late-stage metastatic breast cancer

Araki, S., Eitel, J. A., Batuello, C. N., Bijangi-Vishehsaraei, K., Xie, X.-J., Danielpour, D., Pollok, K. E., Boothman, D. A., & Mayo, L. D. (2010) · Journal of Clinical Investigation

TGF-β signaling in diseasesCancer-related Molecular Pathways

Cited by 133

Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1α and Hdm2

LaRusch, G. A., Jackson, M. W., Dunbar, J. D., Warren, R. S., Donner, D. B., & Mayo, L. D. (2007) · Cancer Research

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 89

Combination therapy in a xenograft model of glioblastoma: Enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

Wang, H., Cai, S., Bailey, B. J., Reza Saadatzadeh, M., Ding, J., Tonsing-Carter, E., Georgiadis, T. M., Zachary Gunter, T., Long, E. C., Minto, R. E., et al. (2017) · Journal of Neurosurgery

Glioma Diagnosis and TreatmentCancer-related Molecular Pathways

Cited by 49

Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization

Gama, V, Gomez, J. A., Mayo, L. D., Jackson, M. W., Danielpour, D., Song, K., Haas, A. L., Laughlin, M. J., & Matsuyama, S. (2009) · Cell Death & Differentiation

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 46

Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model

Tonsing-Carter, E., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Wang, H., Sinn, A. L., Peterman, K. M., Spragins, T. K., Silver, J. M., Sprouse, A. A., et al. (2015) · Molecular Cancer Therapeutics

Cancer-related Molecular PathwaysBreast Cancer Treatment Studies

Cited by 42

Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity

Cai, S., Wang, H., Bailey, B., Ernstberger, A., Juliar, B. E., Sinn, A. L., Chan, R. J., Jones, D. R., Mayo, L. D., Baluyut, A. R., et al. (2011) · Clinical Cancer Research

Hematopoietic Stem Cell TransplantationImmunotoxicology and immune responses

Cited by 32

Hdm2 Nuclear Export, Regulated by Insulin-like Growth Factor-I/MAPK/p90Rsk Signaling, Mediates the Transformation of Human Cells

Jackson, M. W., Patt, L. E., LaRusch, G. A., Donner, D. B., Stark, G. R., & Mayo, L. D. (2006) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 29

Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis

Cipriano, R., Patton, J. T., Mayo, L. D., & Jackson, M. W. (2010) · Cell Cycle

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 20

Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis

Lehman, J., & Mayo, L. (2012) · International Journal of Molecular Sciences

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 9