Hdm2 Nuclear Export, Regulated by Insulin-like Growth Factor-I/MAPK/p90Rsk Signaling, Mediates the Transformation of Human Cells

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

Chan, J. M., Stampfer, M. J., Giovannucci, E. L., Gann, P. H., Ma, J., Wilkinson, P., Hennekens, C. H., & Pollak, M. (1998) · Science · doi:10.1126/science.279.5350.563 · Cited by 1,992 · see citing works

The p53 pathway: positive and negative feedback loops

Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967 · see citing works

A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

Bond, G. L., Hu, W., Bond, E. E., Robins, H., Lutzker, S. G., Arva, N. C., Bargonetti, J., Bartel, F., Taubert, H., Wuerl, P., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.022 · Cited by 1,265 · see citing works

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

Mayo, L. D., & Donner, D. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181181198 · Cited by 1,230 · see citing works

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., & Hung, M.-C. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-973 · Cited by 951 · see citing works

p19ARF links the tumour suppressor p53 to Ras

Palmero, I., Pantoja, C., & Serrano, M. (1998) · Nature · doi:10.1038/25870 · Cited by 617 · see citing works

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

Freedman, D. A., & Levine, A. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7288 · Cited by 513 · see citing works

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract.

Hammond, S., Ham, R. G., & Stampfer, M. R. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.17.5435 · Cited by 437 · see citing works

Opposing Effects of Ras on p53

Ries, S., Biederer, C., Woods, D., Shifman, O., Shirasawa, S., Sasazuki, T., McMahon, M., Oren, M., & McCormick, F. (2000) · Cell · doi:10.1016/s0092-8674(00)00123-9 · Cited by 357 · see citing works

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

Tao, W., & Levine, A. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3077 · Cited by 355 · see citing works

MDM2 and Prognosis

Onel, K., & Cordon‐Cardo, C. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.1.2.1 · Cited by 227 · see citing works

Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors.

Wu, Y., Cui, K. Y., Miyoshi, K., Hennighausen, L. G., Green, J. E., Setser, J., LeRoith, D., & Yakar, S. (2003) · PubMed · Cited by 201 · see citing works

Tyrosine phosphorylation of Mdm2 by c‐Abl: implications for p53 regulation

Goldberg, Z., Sionov, R. V., Berger, M., Zwang, Y., Perets, R., Etten, R. A. V., Oren, M., Taya, Y., & Haupt, Y. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf384 · Cited by 200 · see citing works

Phosphorylation of HDM2 by Akt

Ashcroft, M., Ludwig, R. L., Woods, D. B., Copeland, T. D., Weber, H. O., MacRae, E. J., & Vousden, K. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205276 · Cited by 197 · see citing works

Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3

Patton, J. T., Mayo, L. D., Singhi, A. D., Gudkov, A. V., Stark, G. R., & Jackson, M. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3832 · Cited by 189 · see citing works

Transformation of normal human cells in the absence of telomerase activation

Seger, Y. R., Garcı́a-Cao, M., Piccinin, S., Cunsolo, C. L., Doglioni, C., Blasco, M. A., Hannon, G. J., & Maestro, R. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00183-6 · Cited by 159 · see citing works

Insulin-like Growth Factor I Induces MDM2-dependent Degradation of p53 via the p38 MAPK Pathway in Response to DNA Damage

Héron‐Milhavet, L., & LeRoith, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111142200 · Cited by 111 · see citing works

p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.

Phelps, M., Darley, M., Primrose, J. N., & Blaydes, J. P. (2003) · PubMed · Cited by 108 · see citing works

Ras-MAP Kinase Signaling Pathways and Control of Cell Proliferation: Relevance to Cancer Therapy

Shapiro, P. S. (2002) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360290795538 · Cited by 107 · see citing works

Association of insulin‐like growth‐factor‐I‐induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF‐7 cells

Takahashi, K., & Suzuki, K. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910550322 · Cited by 61 · see citing works

HDM2 phosphorylation by MAPKAP kinase 2

Weber, H. O., Ludwig, R. L., Morrison, D. K., Kotlyarov, A., Gaestel, M., & Vousden, K. H. (2005) · Oncogene · doi:10.1038/sj.onc.1208389 · Cited by 60 · see citing works

MEK-ERK Signaling Controls Hdm2 Oncoprotein Expression by Regulating hdm2 mRNA Export to the Cytoplasm

Phelps, M., Phillips, A., Darley, M., & Blaydes, J. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412334200 · Cited by 57 · see citing works

Regulation of p53 expression by the RAS-MAP kinase pathway

Agarwal, M. L., Ramana, C. V., Hamilton, M., Taylor, W. R., DePrimo, S. E., Bean, L. J., Agarwal, A. M., Agarwal, M. K., Wolfman, A., & Stark, G. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204353 · Cited by 52 · see citing works

P53 licensed to kill? Operating the assassin

Haupt, S. M., Louria‐Hayon, I., & Haupt, Y. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10311 · Cited by 31 · see citing works

MDM2, MDMX and p53 in oncogenesis and cancer therapy

Wade, M., Li, Y.-C., & Wahl, G. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3430 · Cited by 1,279 · see citing works

FOXOs: signalling integrators for homeostasis maintenance

Eijkelenboom, A., & Burgering, B. M. T. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3507 · Cited by 1,081 · see citing works

TGF-β1–induced expression of human Mdm2 correlates with late-stage metastatic breast cancer

Araki, S., Eitel, J. A., Batuello, C. N., Bijangi-Vishehsaraei, K., Xie, X.-J., Danielpour, D., Pollok, K. E., Boothman, D. A., & Mayo, L. D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39194 · Cited by 133 · see citing works

APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival

Cardoso, A. A., Jiang, Y., Luo, M., Reed, A. M., Shahda, S., He, Y., Maitra, A., Kelley, M. R., & Fishel, M. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047462 · Cited by 105 · see citing works

Pim kinases in hematological malignancies: where are we now and where are we going?

Mondello, P., Cuzzocrea, S., & Mian, M. (2014) · Journal of Hematology & Oncology · doi:10.1186/s13045-014-0095-z · Cited by 95 · see citing works

Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma

Hogan, C., Hutchison, C., Marcar, L., Milne, D., Saville, M. K., Goodlad, J. R., Kernohan, N., & Meek, D. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709695200 · Cited by 85 · see citing works

Regulation of MDMX Expression by Mitogenic Signaling

Gilkes, D. M., Pan, Y., Coppola, D., Yeatman, T., Reuther, G. W., & Chen, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01633-07 · Cited by 82 · see citing works

The regulation of MDM2 by multisite phosphorylation—opportunities for molecular-based intervention to target tumours?

Meek, D. W., & Hupp, T. R. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2009.10.005 · Cited by 76 · see citing works

Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53

Zhou, R., Shañas, R., Nelson, M. A., Bhattacharyya, A. K., & Shi, J. (2009) · International Journal of Cancer · doi:10.1002/ijc.24744 · Cited by 65 · see citing works

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies

Cipriano, R., Miskimen, K. L. S., Bryson, B. L., Foy, C. R., Bartel, C. A., & Jackson, M. W. (2013) · Oncotarget · doi:10.18632/oncotarget.1027 · Cited by 60 · see citing works

Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice

Jung, C., Lim, J. H., Choi, Y., Kim, D., Kang, K. J., Noh, S., & Im, D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42674 · Cited by 54 · see citing works

A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop

Xiong, L., Kou, F., Yang, Y., & Wu, J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703044 · Cited by 49 · see citing works

Nutlin-3, an Hdm2 antagonist, inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1α

Lee, Y.-M., Lim, J.-H., Chun, Y., Moon, H.-E., Lee, M. K., Huang, E. L., & Park, J. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp196 · Cited by 49 · see citing works

The β Subunit of Voltage-gated Ca2+ Channels Interacts with and Regulates the Activity of a Novel Isoform of Pax6

Zhang, Y., Yamada, Y. M. A., Fan, M., Bangaru, S. D., Lin, B., & Yang, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.022236 · Cited by 48 · see citing works

Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospects

Rathi, A., Kumar, D., Hasan, G. M., Haque, M. M., & Hassan, M. I. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.129995 · Cited by 42 · see citing works

Sulfur mustard induced cytokine production and cell death: Investigating the potential roles of the p38, p53, and NF‐κB signaling pathways with RNA interference

Ruff, A. L., & Dillman, J. F. (2010) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.20321 · Cited by 39 · see citing works

Induction of Apoptotic Genes by a p73-Phosphatase and Tensin Homolog (p73-PTEN) Protein Complex in Response to Genotoxic Stress

Lehman, J. A., Waning, D. L., Batuello, C. N., Cipriano, R., Kadakia, M., & Mayo, L. D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.217620 · Cited by 27 · see citing works

Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival

Froment, P., Dupont, J., & Marine, J. (2008) · Cell Cycle · doi:10.4161/cc.7.19.6807 · Cited by 24 · see citing works

Up-Regulation of Hepatitis C Virus Replication and Production by Inhibition of MEK/ERK Signaling

Ndjomou, J., Park, I.-W., Liu, Y., Mayo, L. D., & He, J. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007498 · Cited by 21 · see citing works

Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation

Qin, Q., Liao, G., Baudry, M., & Bi, X. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009999 · Cited by 20 · see citing works

Role of p90RSK in regulating the Crabtree effect: implications for cancer

Redman, E., Brookes, P. S., & Karcz, M. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120277 · Cited by 18 · see citing works

Signaling Pathways Involved in Megakaryocyte‐Mediated Proliferation of Osteoblast Lineage Cells

Cheng, Y., Streicher, D. A., Waning, D. L., Chitteti, B. R., Gerard-O’Riley, R. L., Horowitz, M. C., Bidwell, J. P., Pavalko, F. M., Srour, E. F., Mayo, L. D., et al. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24774 · Cited by 17 · see citing works

Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS

Liu, X., Zhang, Y., Wang, S., Liu, G., & Ruan, L. (2018) · Royal Society Open Science · doi:10.1098/rsos.172376 · Cited by 17 · see citing works

Enhancement of ligand-dependent down-regulation of glucocorticoid receptor by lipopolysaccharide

Hirasawa, N., Yashima, K., & Ishihara, K. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.08.012 · Cited by 14 · see citing works

The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2)

Hauck, P. M., Wolf, E. R., Olivos, D. J., McAtarsney, C. P., & Mayo, L. D. (2017) · Oncotarget · doi:10.18632/oncotarget.22320 · Cited by 6 · see citing works

Therapeutic considerations for Mdm2: not just a one trick pony

Lehman, J. A., Eitel, J. A., Batuello, C. N., & Mayo, L. D. (2008) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.3.11.1309 · Cited by 5 · see citing works

Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation

Venkataraman, A., Coleman, D. J., Nevrivy, D. J., Long, T., Kioussi, C., Indra, A. K., & Leid, M. E. (2014) · Photochemical & Photobiological Sciences · doi:10.1039/c3pp50351h · Cited by 3 · see citing works

Activation of the Snail transcription factor induces Mdm2 gene expression

Mabry, A., Gorman, J., Delvasto, J. S., LAVIK, A. R., Layer, J. H., & Mayo, L. D. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107811 · Cited by 1 · see citing works

Multiple modes of Mdmx regulation affect p53 activation

Gilkes, D. M. (2008) · Digital Commons - University of South Florida (University of South Florida)

IGF-I receptor signaling in mammalian cell growth and transformation

Swantek, J. L. (1995) · The Medicine Forum

Insulin-like Growth Factor-I-Dependent Signal Transduction Pathways Leading to the Induction of Cell Growth and Differentiation of Human Neuroblastoma Cell Line SH-SY5Y. The Roles of MAP Kinase Pathway and PI 3-Kinase Pathway.

Kurihara, S., Hakuno, F., & Takahashi, S. (2000) · Endocrine Journal · doi:10.1507/endocrj.47.739 · Cited by 82 · see citing works

MEK-ERK Signaling Controls Hdm2 Oncoprotein Expression by Regulating hdm2 mRNA Export to the Cytoplasm

Phelps, M., Phillips, A., Darley, M., & Blaydes, J. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412334200 · Cited by 57 · see citing works

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

Mayo, L. D., & Donner, D. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181181198 · Cited by 1,230 · see citing works

Insulin-like growth factor-I induces the phosphorylation and nuclear exclusion of forkhead transcription factors in human neuroblastoma cells

Schwab, T. S., Madison, B., Grauman, A., & Feldman, E. L. (2005) · APOPTOSIS · doi:10.1007/s10495-005-0429-y · Cited by 35 · see citing works