Hamel, Ernest

Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol,

ter Haar, E., Kowalski, R. J., Hamel, E., Lin, C. M., Longley, R. E., Gunasekera, S. P., Rosenkranz, H. S., & Day, B. W. (1996) · Biochemistry

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 382

Structure of curacin A, a novel antimitotic, antiproliferative and brine shrimp toxic natural product from the marine cyanobacterium Lyngbya majuscula

Gerwick, W. H., Proteau, P. J., Nagle, D. G., Hamel, E., Blokhin, A., & Slate, D. L. (1994) · The Journal of Organic Chemistry

Microbial Natural Products and BiosynthesisMarine Sponges and Natural Products

Cited by 365

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal

Bai, R., Petit, G. R., & Hamel, E. (1990) · Biochemical Pharmacology

Microtubule and mitosis dynamicsMicrobial Natural Products and Biosynthesis

Cited by 321

Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly

Marquez, B. L., Watts, K. S., Yokochi, A., Roberts, M. A., Verdier-Pinard, P., Jimenez, J. I., Hamel, E., Scheuer, P. J., & Gerwick, W. H. (2002) · Journal of Natural Products

Microbial Natural Products and BiosynthesisMarine Sponges and Natural Products

Cited by 181

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites

Buey, R. M., Calvo, E., Barasoain, I., Pineda, O., Edler, M. C., Matesanz, R., Cerezo, G., Vanderwal, C. D., Day, B. W., Sorensen, E. J., et al. (2007) · Nature Chemical Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 156

Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198

LaVallee, T. M., Burke, P. A., Swartz, G. M., Hamel, E., Agoston, G. E., Shah, J., Suwandi, L., Hanson, A. D., Fogler, W. E., Sidor, C. F., et al. (2008) · Molecular Cancer Therapeutics

Heterocyclic Compound Synthesis and BioactivityMicrotubule and mitosis dynamics

Cited by 67