Structure of curacin A, a novel antimitotic, antiproliferative and brine shrimp toxic natural product from the marine cyanobacterium Lyngbya majuscula
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majusculaWilliam H. Gerwick, Philip J. Proteau, Dale G. Nagle, Ernest Hamel, Andrei Blokhin, and Doris L. SlateCite this: J. Org. Chem. 1994, 59, 6, 1243–1245Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/jo00085a006https://doi.org/10.1021/jo00085a006research-articleACS PublicationsRequest reuse permissionsArticle Views1628Altmetric-Citations295LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
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Cyanobacteria are a rich source of highly bioactive natural products, and in particular, protease inhibitors from numerous chemical classes.
“Cyanobacteria are known to be a rich source of highly bioactive natural products32–35, and in particular, protease inhibitors from numerous chemical classes36–41.”
From Native metabolomics identifies the rivulariapeptolide family of protease inhibitors (2022) · cites this paper as [33]
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Self-citation
- Authors
- Gerwick, W. H., Proteau, P. J., Nagle, D. G., Hamel, E., Blokhin, A., & Slate, D. L.
- Venue
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1994-03
- Volume
- 59
- Issue
- 6
- Pages
- 1243-1245
- ISSN
- 0022-3263 (ISSN-L)
- 1520-6904
- OpenAlex
- W2042515595
- Cited by
- 365
- References
- 0
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 3 · 2023: 12 · 2022: 12 · 2021: 6 · 2020: 12 · 2019: 15 · 2018: 7 · 2017: 9 · 2016: 14 · 2015: 13 · 2014: 12 · 2013: 11 · 2012: 23
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Organic Chemistry (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Synthesis and Biological Activity
- Keywords
- curacin A, Lyngbya majuscula, marine cyanobacteria, natural product structure, antimitotic activity, antiproliferative activity, brine shrimp toxicity, cyanotoxins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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