Delgoffe, Greg M.

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Scharping, N. E., Rivadeneira, D. B., Menk, A. V., Vignali, P. D. A., Ford, B. R., Rittenhouse, N. L., Peralta, R., Wang, Y., Wang, Y., DePeaux, K., et al. (2021) · Nature Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 897

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

Bengsch, B., Johnson, A. L., Kurachi, M., Odorizzi, P. M., Pauken, K. E., Attanasio, J., Stelekati, E., McLane, L. M., Paley, M. A., Delgoffe, G. M., et al. (2016) · Immunity

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 868

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Scharping, N. E., Menk, A. V., Moreci, R. S., Whetstone, R. D., Dadey, R. E., Watkins, S. C., Ferris, R. L., & Delgoffe, G. M. (2016) · Immunity

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 848

Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

Overacre-Delgoffe, A. E., Chikina, M., Dadey, R. E., Yano, H., Brunazzi, E. A., Shayan, G., Horne, W., Moskovitz, J. M., Kolls, J. K., Sander, C., et al. (2017) · Cell

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 627

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

Delgoffe, G. M., Woo, S.-R., Turnis, M. E., Gravano, D. M., Guy, C., Overacre, A. E., Bettini, M. L., Vogel, P., Finkelstein, D., Bonnevier, J., et al. (2013) · Nature

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 587

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

Scharping, N. E., Menk, A. V., Whetstone, R. D., Zeng, X., & Delgoffe, G. M. (2017) · Cancer Immunology Research

Cancer Immunotherapy and BiomarkersCancer, Hypoxia, and Metabolism

Cited by 520

Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity

Vignali, P. D. A., DePeaux, K., Watson, M. J., Ye, C., Ford, B. R., Lontos, K., McGaa, N. K., Scharping, N. E., Menk, A. V., Robson, S. C., et al. (2023) · Nature Immunology

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 269

ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation

Vendetti, F. P., Karukonda, P., Clump, D. A., Teo, T., Lalonde, R., Nugent, K., Ballew, M., Kiesel, B. F., Beumer, J. H., Sarkar, S. N., et al. (2018) · Journal of Clinical Investigation

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 198

Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted

Tilstra, J. S., Avery, L., Menk, A. V., Gordon, R. A., Smita, S., Kane, L. P., Chikina, M., Delgoffe, G. M., & Shlomchik, M. J. (2018) · Journal of Clinical Investigation

Systemic Lupus Erythematosus ResearchT-cell and B-cell Immunology

Cited by 149

Tumor hypoxia is associated with resistance to PD-1 blockade in squamous cell carcinoma of the head and neck

Zandberg, D. P., Menk, A. V., Velez, M., Normolle, D., DePeaux, K., Liu, A., Ferris, R. L., & Delgoffe, G. M. (2021) · Journal for ImmunoTherapy of Cancer

Cancer Immunotherapy and BiomarkersCancer, Hypoxia, and Metabolism

Cited by 119

mTORC2 deficiency alters the metabolic profile of conventional dendritic cells

Watson, A. R., Dai, H., Zheng, Y., Nakano, R., Giannou, A. D., Menk, A. V., Stolz, D. B., Delgoffe, G. M., & Thomson, A. W. (2019) · Frontiers in Immunology

Immunotherapy and Immune ResponsesPI3K/AKT/mTOR signaling in cancer

Cited by 15