Kaelin, William G.

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 3,251

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

Lu, G., Middleton, R. E., Sun, H., Naniong, M., Ott, C. J., Mitsiades, C. S., Wong, K.-K., Bradner, J. E., & Kaelin, W. G. (2014) · Science

Protein Degradation and InhibitorsMultiple Myeloma Research and Treatments

Cited by 1,583

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T.-Y., Huang, L. E., Pavletich, N., Chau, V., & Kaelin, W. G. (2000) · Nature Cell Biology

Ubiquitin and proteasome pathwaysCancer, Hypoxia, and Metabolism

Cited by 1,577

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development

PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

Cited by 1,384

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

Miao, D., Margolis, C. A., Gao, W., Voss, M. H., Li, W., Martini, D. J., Norton, C., Bossé, D., Wankowicz, S. M., Cullen, D., et al. (2018) · Science

Cancer Immunotherapy and BiomarkersChromatin Remodeling and Cancer

Cited by 1,249

Influence of Metabolism on Epigenetics and Disease

Kaelin, W. G., & McKnight, S. L. (2013) · Cell

Epigenetics and DNA MethylationCancer, Hypoxia, and Metabolism

Cited by 920

Molecular basis of the VHL hereditary cancer syndrome

Kaelin, W. G. (2002) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismEar and Head Tumors

Cited by 865

Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

Min, J.-H., Yang, H., Ivan, M., Gertler, F., Kaelin, W. G., & Pavletich, N. P. (2002) · Science

Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathways

Cited by 765

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

Kondo, K., Klco, J., Nakamura, E., Lechpammer, M., & Kaelin, W. G. (2002) · Cancer Cell

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 761

( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Losman, J.-A., Looper, R. E., Koivunen, P., Lee, S., Schneider, R. K., McMahon, C., Cowley, G. S., Root, D. E., Ebert, B. L., & Kaelin, W. G. (2013) · Science

Acute Myeloid Leukemia ResearchCancer, Hypoxia, and Metabolism

Cited by 703

Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth

Kondo, K., Kim, W. Y., Lechpammer, M., & Kaelin, W. G. (2003) · PLoS Biology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 611

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

Kamura, T., Sato, S., Haque, D., Liu, L., Kaelin, W. G., Conaway, R. C., & Conaway, J. W. (1998) · Genes & Development

Cytokine Signaling Pathways and InteractionsUbiquitin and proteasome pathways

Cited by 595

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

Losman, J.-A., & Kaelin, W. G. (2013) · Genes & Development

Cancer, Hypoxia, and MetabolismGlioma Diagnosis and Treatment

Cited by 570

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

Ivan, M., Haberberger, T., Gervasi, D. C., Michelson, K. S., Günzler, V., Kondo, K., Yang, H., Sorokina, I., Conaway, R. C., Conaway, J. W., et al. (2002) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 561

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

Brugarolas, J. B., Vazquez, F., Reddy, A., Sellers, W. R., & Kaelin, W. G. (2003) · Cancer Cell

Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 528

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

Lee, S., Nakamura, E., Yang, H., Wei, W., Linggi, M. S., Sajan, M. P., Farese, R. V., Freeman, R. S., Carter, B. D., Kaelin, W. G., et al. (2005) · Cancer Cell

Adrenal and Paraganglionic TumorsCell death mechanisms and regulation

Cited by 527

Targeting the HIF2–VEGF axis in renal cell carcinoma

Choueiri, T. K., & Kaelin, W. G. (2020) · Nature Medicine

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 477

Proline hydroxylation and gene expression

Kaelin, W. G. (2005) · Annual Review of Biochemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 468

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

Cho, H., Du, X., Rizzi, J. P., Liberzon, E., Chakraborty, A. A., Gao, W., Carvo, I., Signoretti, S., Bruick, R. K., Josey, J. A., et al. (2016) · Nature

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 451

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

Chakraborty, A. A., Laukka, T., Myllykoski, M., Ringel, A. E., Booker, M. A., Tolstorukov, M. Y., Meng, Y. J., Meier, S. R., Jennings, R. B., Creech, A. L., et al. (2019) · Science

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 432

Genetic and Functional Studies Implicate HIF1 α as a 14q Kidney Cancer Suppressor Gene

Shen, C., Beroukhim, R., Schumacher, S. E., Zhou, J., Chang, M., Signoretti, S., & Kaelin, W. G. (2011) · Cancer Discovery

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 413

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

Wei, W., Jin, J., Schlisio, S., Harper, J. W., & Kaelin, W. G. (2005) · Cancer Cell

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 403

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

McBrayer, S. K., Mayers, J. R., DiNatale, G. J., Shi, D. D., Khanal, J., Chakraborty, A. A., Sarosiek, K. A., Briggs, K. J., Robbins, A. K., Sewastianik, T., et al. (2018) · Cell

Cancer, Hypoxia, and MetabolismGlioma Diagnosis and Treatment

Cited by 368

HIF hydroxylation and the mammalian oxygen-sensing pathway

Safran, M., & Kaelin, W. G. (2003) · Journal of Clinical Investigation

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 365