Kaelin, William G.

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

Sellers, W. R., Novitch, B. G., Miyake, S., Heith, A., Otterson, G. A., Kaye, F. J., Lassar, A. B., & Kaelin, W. G. (1998) · Genes & Development

Cancer-related Molecular PathwaysChromatin Remodeling and Cancer

Cited by 343

The von Hippel-Lindau Tumor Suppressor Protein and Clear Cell Renal Carcinoma

Kaelin, W. G. (2007) · Clinical Cancer Research

Renal cell carcinoma treatmentCancer, Hypoxia, and Metabolism

Cited by 336

MDM2 suppresses p73 function without promoting p73 degradation

Zeng, X., Chen, L., Jost, C. A., Maya, R., Keller, D., Wang, X., Kaelin, W. G., Oren, M., Chen, J., & Lu, H. (1999) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 334

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

Laukka, T., Mariani, C. J., Ihantola, T., Cao, J. Z., Hokkanen, J., Kaelin, W. G., Godley, L. A., & Koivunen, P. (2016) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 307

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

Safran, M., Kim, W. Y., O'Connell, F., Flippin, L., Günzler, V., Horner, J. W., DePinho, R. A., & Kaelin, W. G. (2006) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 305

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

Minamishima, Y. A., Moslehi, J., Bardeesy, N., Cullen, D., Bronson, R. T., & Kaelin, W. G. (2008) · Blood

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 294

The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

Ivan, M., & Kaelin, W. G. (2017) · Molecular Cell

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 273

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

Young, A. P., Schlisio, S., Minamishima, Y. A., Zhang, Q., Li, L., Grisanzio, C., Signoretti, S., & Kaelin, W. G. (2008) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceCancer, Hypoxia, and Metabolism

Cited by 239

Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo

Kim, W. Y., Safran, M., Buckley, M. R., Ebert, B. L., Glickman, J., Bosenberg, M., Regan, M., & Kaelin, W. G. (2006) · The EMBO Journal

Cancer, Hypoxia, and MetabolismEar and Head Tumors

Cited by 235

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

Olenyuk, B. Z., Zhang, G.-J., Klco, J. M., Nickols, N. G., Kaelin, W. G., & Dervan, P. B. (2004) · Proceedings of the National Academy of Sciences

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 219

The Hypoxia-Inducible Factor 2 α N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In Vivo

Yan, Q., Bartz, S., Mao, M., Li, L., & Kaelin, W. G. (2007) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 193

Common pitfalls in preclinical cancer target validation

Kaelin, W. G. (2017) · Nature Reviews Cancer

Computational Drug Discovery MethodsCancer Mechanisms and Therapy

Cited by 175

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit

Binné, U. K., Classon, M. K., Dick, F. A., Wei, W., Rape, M., Kaelin, W. G., Näär, A. M., & Dyson, N. J. (2007) · Nature Cell Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 175

ROS: Really involved in Oxygen Sensing

Kaelin, W. G. (2005) · Cell Metabolism

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 173

Reactivation of hepatic EPO synthesis in mice after PHD loss

Minamishima, Y. A., & Kaelin, W. G. (2010) · Science

Erythropoietin and Anemia TreatmentHemoglobin structure and function

Cited by 163

Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases

Kaelin, W. G. (2011) · Cold Spring Harbor Symposia on Quantitative Biology

Cancer, Hypoxia, and MetabolismFerroptosis and cancer prognosis

Cited by 161

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo

Minamishima, Y. A., Moslehi, J., Padera, R. F., Bronson, R. T., Liao, R., & Kaelin, W. G. (2009) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 161

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

German, N. J., Yoon, H., Yusuf, R. Z., Murphy, J. P., Finley, L. W. S., Laurent, G., Haas, W., Satterstrom, F. K., Guarnerio, J., Zaganjor, E., et al. (2016) · Molecular Cell

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 156

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

Kim, W. Y., Perera, S., Zhou, B., Carretero, J., Yeh, J. J., Heathcote, S. A., Jackson, A. L., Nikolinakos, P., Ospina, B., Naumov, G., et al. (2009) · Journal of Clinical Investigation

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 141

The von Hippel-Lindau gene, kidney cancer, and oxygen sensing.

Kaelin, W. G. (2003) · Journal of the American Society of Nephrology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 135

Mouse Reporter Strain for Noninvasive Bioluminescent Imaging of Cells that Have Undergone Cre-Mediated Recombination

Safran, M., Kim, W. Y., Kung, A. L., Horner, J. W., Depinho, R. A., & Kaelin, W. G. (2003) · Molecular Imaging

bioluminescence and chemiluminescence researchAnimal Genetics and Reproduction

Cited by 134

Cells Degrade a Novel Inhibitor of Differentiation with E1A-Like Properties upon Exiting the Cell Cycle

Miyake, S., Sellers, W. R., Safran, M., Li, X., Zhao, W., Grossman, S. R., Gan, J., DeCaprio, J. A., Adams, P. D., & Kaelin, W. G. (2000) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 112

HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy

Jiang, Q., Braun, D. A., Clauser, K. R., Ramesh, V., Shirole, N. H., Duke-Cohan, J. E., Nabilsi, N., Kramer, N. J., Forman, C., Lippincott, I. E., et al. (2025) · Cell

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 68

SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling

Kaelin, W. G. (2009) · Cancer Cell

Adrenal and Paraganglionic TumorsMetabolism and Genetic Disorders

Cited by 67