Kohane, Isaac S.

Framing the challenges of artificial intelligence in medicine

Yu, K.-H., & Kohane, I. S. (2019) · BMJ Quality & Safety

Artificial Intelligence in Healthcare and EducationEthics and Social Impacts of AI

Cited by 233

Electronic Patient-Physician Communication: Problems and Promise

Mandl, K. D., Kohane, I. S., & Brandt, A. M. (1998) · Annals of Internal Medicine

Electronic Health Records SystemsTelemedicine and Telehealth Implementation

Cited by 222

Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system

Clements, C. C., Castro, V. M., Blumenthal, S. R., Rosenfield, H. R., Murphy, S. N., Fava, M., Erb, J. L., Churchill, S. E., Kaimal, A. J., Doyle, A. E., et al. (2015) · Molecular Psychiatry

Pregnancy and Medication ImpactPrenatal Substance Exposure Effects

Cited by 197

Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model

Perlis, R. H., Iosifescu, D. V., Castro, V. M., Murphy, S. N., Gainer, V. S., Minnier, J., Cai, T., Goryachev, S., Zeng, Q., Gallagher, P. J., et al. (2012) · Psychological Medicine

Treatment of Major DepressionMachine Learning in Healthcare

Cited by 193

An Electronic Health Records Study of Long-Term Weight Gain Following Antidepressant Use

Blumenthal, S. R., Castro, V. M., Clements, C. C., Rosenfield, H. R., Murphy, S. N., Fava, M., Weilburg, J. B., Erb, J. L., Churchill, S. E., Kohane, I. S., et al. (2014) · JAMA Psychiatry

Pharmacology and Obesity TreatmentTreatment of Major Depression

Cited by 151

Medical Artificial Intelligence and Human Values

Yu, K.-H., Healey, E., Leong, T.-Y., Kohane, I. S., & Manrai, A. K. (2024) · New England Journal of Medicine

Artificial Intelligence in Healthcare and EducationEthics and Social Impacts of AI

Cited by 149

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Czamara, D., Eraslan, G., Page, C. M., Lahti, J., Lahti-Pulkkinen, M., Hämäläinen, E., Kajantie, E., Laivuori, H., Villa, P. M., Reynolds, R. M., et al. (2019) · Nature Communications

Epigenetics and DNA MethylationBirth, Development, and Health

Cited by 143

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., et al. (2015) · Neuron

Stress Responses and CortisolGenetic Associations and Epidemiology

Cited by 142

Increasing the efficiency of trial-patient matching: automated clinical trial eligibility Pre-screening for pediatric oncology patients

Ni, Y., Wright, J., Perentesis, J., Lingren, T., Deleger, L., Kaiser, M., Kohane, I., & Solti, I. (2015) · BMC Medical Informatics and Decision Making

Electronic Health Records SystemsArtificial Intelligence in Healthcare and Education

Cited by 142

Psychiatric co‐morbidity is associated with increased risk of surgery in Crohn's disease

Ananthakrishnan, A. N., Gainer, V. S., Perez, R. G., Cai, T., Cheng, S. ‐., Savova, G., Chen, P., Szolovits, P., Xia, Z., De Jager, P. L., et al. (2013) · Alimentary Pharmacology & Therapeutics

Inflammatory Bowel DiseaseTryptophan and brain disorders

Cited by 122

Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells

Wu, E., Palmer, N., Tian, Z., Moseman, A. P., Galdzicki, M., Wang, X., Berger, B., Zhang, H., & Kohane, I. S. (2008) · PLoS ONE

Fibroblast Growth Factor ResearchLiver physiology and pathology

Cited by 118

What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask

Kohane, I. S., Aronow, B. J., Avillach, P., Beaulieu-Jones, B. K., Bellazzi, R., Bradford, R. L., Brat, G. A., Cannataro, M., Cimino, J. J., García-Barrio, N., et al. (2021) · Journal of Medical Internet Research

Electronic Health Records SystemsMedical Coding and Health Information

Cited by 113

Association of Sex With Recurrence of Autism Spectrum Disorder Among Siblings

Palmer, N., Beam, A., Agniel, D., Eran, A., Manrai, A., Spettell, C., Steinberg, G., Mandl, K., Fox, K., Nelson, S. F., et al. (2017) · JAMA Pediatrics

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 89

A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers

Palmer, N. P., Schmid, P. R., Berger, B., & Kohane, I. S. (2012) · Genome Biology

Cancer Cells and MetastasisPluripotent Stem Cells Research

Cited by 86

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects

Peyrot, W. J., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., et al. (2015) · Molecular Psychiatry

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Cited by 84

Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: A replication study

Castro, V. M., Kong, S. W., Clements, C. C., Brady, R., Kaimal, A. J., Doyle, A. E., Robinson, E. B., Churchill, S. E., Kohane, I. S., & Perlis, R. H. (2016) · Translational Psychiatry

Pregnancy and Medication ImpactMaternal Mental Health During Pregnancy and Postpartum

Cited by 82

A multidimensional precision medicine approach identifies an autism subtype characterized by dyslipidemia

Luo, Y., Eran, A., Palmer, N., Avillach, P., Levy-Moonshine, A., Szolovits, P., & Kohane, I. S. (2020) · Nature Medicine

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 78

Medicine’s Uncomfortable Relationship With Math: Calculating Positive Predictive Value

Manrai, A. K., Bhatia, G., Strymish, J., Kohane, I. S., & Jain, S. H. (2014) · JAMA Internal Medicine

Palliative Care and End-of-Life IssuesPalliative and Oncologic Care

Cited by 74

Medication use in the management of comorbidities among individuals with autism spectrum disorder from a large nationwide insurance database

Feroe, A. G., Uppal, N., Gutiérrez-Sacristán, A., Mousavi, S., Greenspun, P., Surati, R., Kohane, I. S., & Avillach, P. (2021) · JAMA Pediatrics

Autism Spectrum Disorder ResearchChild Nutrition and Feeding Issues

Cited by 72

Comparative RNA editing in autistic and neurotypical cerebella

Eran, A., Li, J. B., Vatalaro, K., McCarthy, J., Rahimov, F., Collins, C., Markianos, K., Margulies, D. M., Brown, E. N., Calvo, S. E., et al. (2013) · Molecular Psychiatry

RNA regulation and diseaseGenetics and Neurodevelopmental Disorders

Cited by 70

Few shot learning for phenotype-driven diagnosis of patients with rare genetic diseases

Alsentzer, E., Li, M. M., Kobren, S. N., Noori, A., Undiagnosed Diseases Network, Kohane, I. S., & Zitnik, M. (2025) · npj Digital Medicine

Genomics and Rare DiseasesMachine Learning in Healthcare

Cited by 54

The twin questions of personalized medicine: who are you and whom do you most resemble?

Kohane, I. S. (2009) · Genome Medicine

Artificial Intelligence in Healthcare and EducationPharmacogenetics and Drug Metabolism

Cited by 38

Scalability and cost-effectiveness analysis of whole genome-wide association studies on Google Cloud Platform and Amazon Web Services

Krissaane, I., De Niz, C., Gutiérrez-Sacristán, A., Korodi, G., Ede, N., Kumar, R., Lyons, J., Manrai, A., Patel, C., Kohane, I., et al. (2020) · Journal of the American Medical Informatics Association

Cloud Computing and Resource ManagementScientific Computing and Data Management

Cited by 28

Identification of autoimmune gene signatures in autism

Jung, J.-Y., Kohane, I. S., & Wall, D. P. (2011) · Translational Psychiatry

Autism Spectrum Disorder ResearchGenetic Associations and Epidemiology

Cited by 24