Varjosalo, Markku

Hedgehog: functions and mechanisms

Varjosalo, M., & Taipale, J. (2008) · Genes & Development

Hedgehog Signaling Pathway StudiesHippo pathway signaling and YAP/TAZ

Cited by 1,217

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo

Wei, G., Badis, G., Berger, M. F., Kivioja, T., Palin, K., Enge, M., Bonke, M., Jolma, A., Varjosalo, M., Gehrke, A. R., et al. (2010) · The EMBO Journal

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 568

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Moliner, R., Girych, M., Brunello, C. A., Kovaleva, V., Biojone, C., Enkavi, G., Antenucci, L., Kot, E. F., Goncharuk, S. A., Kaurinkoski, K., et al. (2023) · Nature Neuroscience

Psychedelics and Drug StudiesTreatment of Major Depression

Cited by 478

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Santio, N. M., Landor, S. K.-J., Vahtera, L., Ylä-Pelto, J., Paloniemi, E., Imanishi, S. Y., Corthals, G., Varjosalo, M., Manoharan, G. B., Uri, A., et al. (2016) · Oncotarget

Developmental Biology and Gene RegulationPI3K/AKT/mTOR signaling in cancer

Cited by 65

PLCG2-associated immune dysregulation (PLAID) comprises broad and distinct clinical presentations related to functional classes of genetic variants

Baysac, K., Sun, G., Nakano, H., Schmitz, E. G., Cruz, A. C., Fisher, C., Bailey, A. C., Abbott, J. K., Aldave Becerra, J. C., Allenspach, E. J., et al. (2024) · Journal of Allergy and Clinical Immunology

Immunodeficiency and Autoimmune DisordersT-cell and B-cell Immunology

Cited by 63

Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

Fred, S. M., Laukkanen, L., Brunello, C. A., Vesa, L., Göös, H., Cardon, I., Moliner, R., Maritzen, T., Varjosalo, M., Casarotto, P. C., et al. (2019) · Journal of Biological Chemistry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 52

UNC-45a promotes myosin folding and stress fiber assembly

Lehtimäki, J. I., Fenix, A. M., Kotila, T. M., Balistreri, G., Paavolainen, L., Varjosalo, M., Burnette, D. T., & Lappalainen, P. (2017) · Journal of Cell Biology

Cellular Mechanics and InteractionsHeat shock proteins research

Cited by 47

Structure and interactions of the endogenous human Commander complex

Laulumaa, S., Kumpula, E.-P., Huiskonen, J. T., & Varjosalo, M. (2024) · Nature Structural & Molecular Biology

Cellular transport and secretionGenetic and Kidney Cyst Diseases

Cited by 46

Structure and Interactions of the Endogenous Human Commander Complex

Laulumaa, S., Kumpula, E.-P., Huiskonen, J. T., & Varjosalo, M. (2023) · Nature Structural & Molecular Biology

Cellular transport and secretionGenetic and Kidney Cyst Diseases

Cited by 46

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

Deen, A. J., Adinolfi, S., Härkönen, J., Patinen, T., Liu, X., Laitinen, T., Takabe, P., Kainulainen, K., Pasonen-Seppänen, S., Gawriyski, L. M., et al. (2024) · Redox Biology

Genomics, phytochemicals, and oxidative stressNF-κB Signaling Pathways

Cited by 27

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

Deen, A. J., Adinolfi, S., Härkönen, J., Patinen, T., Liu, X., Laitinen, T., Takabe, P., Kainulainen, K., Pasonen-Seppänen, S., Gawriyski, L. M., et al. (2023) · Redox Biology

Genomics, phytochemicals, and oxidative stressNF-κB Signaling Pathways

Cited by 27

The comprehensive SARS-CoV-2 ‘hijackome’ knowledge base

Huuskonen, S., Liu, X., Pöhner, I., Redchuk, T., Salokas, K., Lundberg, R., Maljanen, S., Belik, M., Reinholm, A., Kolehmainen, P., et al. (2024) · Cell Discovery

SARS-CoV-2 and COVID-19 ResearchAdvanced Proteomics Techniques and Applications

Cited by 12