Ovaa, Huib

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

Chauhan, D., Catley, L., Li, G., Podar, K., Hideshima, T., Velankar, M., Mitsiades, C., Mitsiades, N., Yasui, H., Letai, A., et al. (2005) · Cancer Cell

Multiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways

Cited by 694

Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family

Borodovsky, A., Ovaa, H., Kolli, N., Gan-Erdene, T., Wilkinson, K. D., Ploegh, H. L., & Kessler, B. M. (2002) · Chemistry & Biology

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 588

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., Steenvoorden, E., Rynearson, K. D., Brouwers, J. F., Helms, J. B., et al. (2019) · Cell Stem Cell

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 350

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

Resnick, E., Bradley, A., Gan, J., Douangamath, A., Krojer, T., Sethi, R., Geurink, P. P., Aimon, A., Amitai, G., Bellini, D., et al. (2019) · Journal of the American Chemical Society

Click Chemistry and ApplicationsChemical Synthesis and Analysis

Cited by 335

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2.

Meulmeester, E., Maurice, M. M., Boutell, C., Teunisse, A. F. A. S., Ovaa, H., Abraham, T. E., Dirks, R. W., & Jochemsen, A. G. (2005) · Molecular Cell

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 260

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

Scott, D. C., Rhee, D. Y., Duda, D. M., Kelsall, I. R., Olszewski, J. L., Paulo, J. A., de Jong, A., Ovaa, H., Alpi, A. F., Harper, J. W., et al. (2016) · Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 229

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

Ovaa, H., Kessler, B. M., Rolén, U., Galardy, P. J., Ploegh, H. L., & Masucci, M. G. (2004) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 190

Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

Horn-Ghetko, D., Krist, D. T., Prabu, J. R., Baek, K., Mulder, M. P. C., Klügel, M., Scott, D. C., Ovaa, H., Kleiger, G., & Schulman, B. A. (2021) · Nature

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 187

Reactive glia show increased immunoproteasome activity in Alzheimer’s disease

Orre, M., Kamphuis, W., Dooves, S., Kooijman, L., Chan, E. T., Kirk, C. J., Dimayuga Smith, V., Koot, S., Mamber, C., Jansen, A. H., et al. (2013) · Brain

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 180

Opportunities for Small Molecules in Cancer Immunotherapy

van der Zanden, S. Y., Luimstra, J. J., Neefjes, J., Borst, J., & Ovaa, H. (2020) · Trends in Immunology

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 119

Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features

Gangaev, A., Ketelaars, S. L. C., Isaeva, O. I., Patiwael, S., Dopler, A., Hoefakker, K., De Biasi, S., Gibellini, L., Mussini, C., Guaraldi, G., et al. (2021) · Nature Communications

vaccines and immunoinformatics approachesSARS-CoV-2 and COVID-19 Research

Cited by 111

Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

Kooij, R., Liu, S., Sapmaz, A., Xin, B.-T., Janssen, G. M. C., van Veelen, P. A., Ovaa, H., Dijke, P. T., & Geurink, P. P. (2020) · Journal of the American Chemical Society

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 82

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.

Kim, R. Q., Geurink, P. P., Mulder, M. P. C., Fish, A., Ekkebus, R., El Oualid, F., van Dijk, W. J., van Dalen, D., Ovaa, H., van Ingen, H., et al. (2019) · Nature Communications

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 41