Knudsen, Lotte Bjerre

Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide

Lau, J., Bloch, P., Schäffer, L., Pettersson, I., Spetzler, J., Kofoed, J., Madsen, K., Knudsen, L. B., McGuire, J., Steensgaard, D. B., et al. (2015) · Journal of Medicinal Chemistry

Diabetes Treatment and ManagementChemical Synthesis and Analysis

Cited by 1,105

The Discovery and Development of Liraglutide and Semaglutide

Knudsen, L. B., & Lau, J. (2019) · Frontiers in Endocrinology

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 970

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

Pyke, C., Heller, R. S., Kirk, R. K., Ørskov, C., Reedtz-Runge, S., Kaastrup, P., Hvelplund, A., Bardram, L., Calatayud, D., & Knudsen, L. B. (2014) · Endocrinology

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 876

Semaglutide lowers body weight in rodents via distributed neural pathways.

Gabery, S., Salinas, C. G., Paulsen, S. J., Ahnfelt-Rønne, J., Alanentalo, T., Baquero, A. F., Buckley, S. T., Farkas, E., Fekete, C., Frederiksen, K. S., et al. (2020) · JCI Insight

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 717

Transcellular Stomach Absorption of a Derivatized Glucagon-Like Peptide-1 Receptor Agonist

Buckley, S. T., Bækdal, T. A., Vegge, A., Maarbjerg, S. J., Pyke, C., Ahnfelt-Rønne, J., Madsen, K. G., Schéele, S. G., Alanentalo, T., Kirk, R. K., et al. (2018) · Science Translational Medicine

Drug Solubulity and Delivery SystemsAdvanced Drug Delivery Systems

Cited by 553

The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways

Rakipovski, G., Rolin, B., Nøhr, J., Klewe, I., Frederiksen, K. S., Augustin, R., Hecksher-Sørensen, J., Ingvorsen, C., Polex-Wolf, J., & Knudsen, L. B. (2018) · JACC: Basic to Translational Science

Diabetes Treatment and ManagementAtherosclerosis and Cardiovascular Diseases

Cited by 509

Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: importance of fatty acid length, polarity, and bulkiness

Madsen, K., Knudsen, L. B., Agersoe, H., Nielsen, P. F., Thøgersen, H., Wilken, M., & Johansen, N. L. (2007) · Journal of Medicinal Chemistry

Diabetes Treatment and ManagementChemical Synthesis and Analysis

Cited by 244

Small-molecule agonists for the glucagon-like peptide 1 receptor

Knudsen, L. B., Kiel, D., Teng, M., Behrens, C., Bhumralkar, D., Kodra, J. T., Holst, J. J., Jeppesen, C. B., Johnson, M. D., de Jong, J. C., et al. (2007) · Proceedings of the National Academy of Sciences

Diabetes Treatment and ManagementReceptor Mechanisms and Signaling

Cited by 232

Treatment with glucagon-like peptide-1 receptor agonists and incidence of dementia: data from pooled double-blind randomized controlled trials and nationwide disease and prescription registers.

Nørgaard, C. H., Friedrich, S., Hansen, C. T., Gerds, T., Ballard, C., Møller, D. V., Knudsen, L. B., Kvist, K., Zinman, B., Holm, E., et al. (2022) · Alzheimer's & Dementia: Translational Research & Clinical Interventions

Diabetes Treatment and ManagementDementia and Cognitive Impairment Research

Cited by 206

A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules

Liu, H., Dear, A. E., Knudsen, L. B., & Simpson, R. W. (2009) · Journal of Endocrinology

Diabetes Treatment and ManagementAdipokines, Inflammation, and Metabolic Diseases

Cited by 187

A genetic map of the mouse dorsal vagal complex and its role in obesity

Ludwig, M. Q., Cheng, W., Gordian, D., Lee, J., Paulsen, S. J., Hansen, S. N., Egerod, K. L., Barkholt, P., Rhodes, C. J., Secher, A., et al. (2021) · Nature Metabolism

Regulation of Appetite and ObesityNeuropeptides and Animal Physiology

Cited by 186

The Glucagon-Like Peptide-1 Receptor—or Not?

Pyke, C., & Knudsen, L. B. (2013) · Endocrinology

Diabetes Treatment and ManagementReceptor Mechanisms and Signaling

Cited by 154

Characterization of the Glucagonlike Peptide-1 Receptor in Male Mouse Brain Using a Novel Antibody and In Situ Hybridization

Jensen, C. B., Pyke, C., Rasch, M. G., Dahl, A. B., Knudsen, L. B., & Secher, A. (2018) · Endocrinology

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 145

Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation

Sourris, K. C., Ding, Y., Maxwell, S. S., Al-sharea, A., Kantharidis, P., Mohan, M., Rosado, C. J., Penfold, S. A., Haase, C., Xu, Y., et al. (2024) · Kidney International

Advanced Glycation End Products researchChronic Kidney Disease and Diabetes

Cited by 143

GLP-1 Induces Barrier Protective Expression in Brunnerʼs Glands and Regulates Colonic Inflammation

Bang-Berthelsen, C. H., Holm, T. L., Pyke, C., Simonsen, L., Søkilde, R., Pociot, F., Heller, R. S., Folkersen, L., Kvist, P. H., Jackerott, M., et al. (2016) · Inflammatory Bowel Diseases

Inflammatory Bowel DiseaseIL-33, ST2, and ILC Pathways

Cited by 111

A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing

Dowsett, G. K. C., Lam, B. Y. H., Tadross, J. A., Cimino, I., Rimmington, D., Coll, A. P., Polex-Wolf, J., Knudsen, L. B., Pyke, C., & Yeo, G. S. H. (2021) · Molecular Metabolism

Regulation of Appetite and ObesitySingle-cell and spatial transcriptomics

Cited by 98

Integrated brain atlas for unbiased mapping of nervous system effects following liraglutide treatment

Salinas, C. B. G., Lu, T. T.-H., Gabery, S., Marstal, K., Alanentalo, T., Mercer, A. J., Cornea, A., Conradsen, K., Hecksher-Sørensen, J., Dahl, A. B., et al. (2018) · Scientific Reports

Cell Image Analysis TechniquesNeuroscience and Neuropharmacology Research

Cited by 95

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

Vrang, N., Jelsing, J., Simonsen, L., Jensen, A. E., Thorup, I., Søeborg, H., & Knudsen, L. B. (2012) · American Journal of Physiology-Endocrinology and Metabolism

Diabetes Treatment and ManagementPancreatitis Pathology and Treatment

Cited by 92

Glucagon‐like peptide‐1 receptor expression in the human eye

Hebsgaard, J. B., Pyke, C., Yildirim, E., Knudsen, L. B., Heegaard, S., & Kvist, P. H. (2018) · Diabetes, Obesity and Metabolism

Retinal Diseases and TreatmentsDiabetes Treatment and Management

Cited by 88

Proteomic changes upon treatment with semaglutide in individuals with obesity

Maretty, L., Gill, D., Simonsen, L., Soh, K., Zagkos, L., Galanakis, M., Sibbesen, J., Iglesias, M. T., Secher, A., Valkenborg, D., et al. (2025) · Nature Medicine

Pharmacology and Obesity TreatmentAdipokines, Inflammation, and Metabolic Diseases

Cited by 86

The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF

Withaar, C., Meems, L. M. G., Nollet, E. E., Schouten, E. M., Schroeder, M. A., Knudsen, L. B., Niss, K., Madsen, C. T., Hoegl, A., Mazzoni, G., et al. (2023) · JACC: Basic to Translational Science

Cardiovascular Function and Risk FactorsHeart Failure Treatment and Management

Cited by 74

The Human GLP-1 Analogs Liraglutide and Semaglutide: Absence of Histopathological Effects on the Pancreas in Nonhuman Primates

Gotfredsen, C. F., Mølck, A.-M., Thorup, I., Nyborg, N. C. B., Salanti, Z., Knudsen, L. B., & Larsen, M. O. (2014) · Diabetes

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 60

Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models

Rupp, A. C., Tomlinson, A. J., Affinati, A. H., Yacawych, W. T., Duensing, A. M., True, C., Lindsley, S. R., Kirigiti, M. A., MacKenzie, A., Polex-Wolf, J., et al. (2023) · Journal of Clinical Investigation

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 55

Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling

Karhunen, V., Daghlas, I., Zuber, V., Vujkovic, M., Olsen, A. K., Knudsen, L. B., Haynes, W. G., Howson, J. M. M., & Gill, D. (2021) · Diabetologia

Genetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 28