Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models

Rupp, Alan C.; Tomlinson, Abigail J.; Affinati, Alison H.; Yacawych, Warren T.; Duensing, Allison M.; True, Cadence; Lindsley, Sarah R.; Kirigiti, Melissa A.; MacKenzie, Alexander; Polex-Wolf, Joseph; Li, Chien; Knudsen, Lotte Bjerre; Seeley, Randy J.; Olson, David P.; Kievit, Paul; Myers, Martin G.

doi:10.1172/jci157515

Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models

The adipose-derived hormone leptin acts via its receptor (LepRb) in the brain to control energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb neurons plays key roles in the restraint of food intake and body weight by leptin. To identify markers for candidate popul…