Holtzman, David M.
Washington University in St. Louis · Hope Center for Neurological Disorders
298 papers on CoChatORCID 0000-0002-3400-0856
Most cited papers
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[O2–17–01]: RESULTS OF A PHASE 1, SINGLE ASCENDING DOSE, PLACEBO‐CONTROLLED STUDY OF ABBV‐8E12 IN PATIENTS WITH PROGRESSIVE SUPRANUCLEAR PALSY AND PHASE 2 STUDY DESIGN IN EARLY ALZHEIMER's DISEASE
Budur, K., West, T., Braunstein, J. B., Fogelman, I., Bordelon, Y. M., Litvan, I., Roberson, E. D., Hu, H., Verghese, P. B., Bateman, R. J., et al. (2017) · Alzheimer's & Dementia
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research
Cited by 12
- Verified
Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype
Lawler, P. E., Bollinger, J. G., Schindler, S. E., Hodge, C. R., Iglesias, N. J., Krishnan, V., Coulton, J. B., Li, Y., Holtzman, D. M., & Bateman, R. J. (2023) · Analytical Biochemistry
Alzheimer's disease research and treatmentsGlycosylation and Glycoproteins Research
Cited by 12
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Proteomic clusters underlie heterogeneity in preclinical Alzheimer’s disease progression
Wisch, J. K., Butt, O. H., Gordon, B. A., Schindler, S. E., Fagan, A. M., Henson, R. L., Yang, C., Boerwinkle, A. H., Benzinger, T. L. S., Holtzman, D. M., et al. (2023) · Brain
Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments
Cited by 11
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Apolipoprotein E levels and Alzheimer risk
Hyman, B. T., & Holtzman, D. M. (2015) · Annals of Neurology
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research
Cited by 9
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Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform
Strickland, M. R., Wang, Z., Golden, L. R., Wang, H., Lu, P., Ren, Y., Tabor, G. T., Zhao, N., Ulrich, J. D., Han, X., et al. (2026) · Journal of Lipid Research
Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms
Cited by 8
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Reply to: Fractional synthesis and clearance rates for amyloid β
Elbert, D. L., Patterson, B. W., Ercole, L., Ovod, V., Kasten, T., Mawuenyega, K., Yarasheski, K., Morris, J. C., Benzinger, T., Holtzman, D. M., et al. (2011) · Nature Medicine
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research
Cited by 3
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ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer’s Disease Pathogenesis
Hernandez Arriaza, R., Reil, D., Fatuzzo, N., Fu, M., Dai, Y., Fernandez Martinez, D., Jiang, H., Holtzman, D. M., Greicius, M. D., & Khosla, C. (2025) · Biochemistry
Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism
Cited by 2
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Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease
Western, D., Yang, C., Timsina, J., Liu, M., Wang, C., Campbell, M. C., Kotzbauer, P., Perlmutter, J. S., Schindler, S. E., Morris, J. C., et al. (2026) · Science Translational Medicine
Genetic Associations and EpidemiologyMultiple Sclerosis Research Studies
Cited by 1
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APOE2 attenuates APOE4-associated amyloid pathology and related toxicity in a mouse model of Alzheimer’s disease
Chen, K., Chen, Y., Ren, Y., Wang, Z., Huang, Y., Pan, M., Li, Z., Casey, M. C., Qiao, W., Shi, J., et al. (2026) · Nature Communications
Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms
Cited by 0
- Verified
ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders
Strickland, M. R., & Holtzman, D. M. (2026) · Molecular Neurodegeneration
Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms
Cited by 0
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