Dougherty, Joseph D.

Application of a translational profiling approach for the comparative analysis of CNS cell types

Doyle, J. P., Dougherty, J. D., Heiman, M., Schmidt, E. F., Stevens, T. R., Ma, G., Bupp, S., Shrestha, P., Shah, R. D., Doughty, M. L., et al. (2008) · Cell

Single-cell and spatial transcriptomicsRNA and protein synthesis mechanisms

Cited by 912

Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity

Coe, B. P., Stessman, H. A. F., Sulovari, A., Geisheker, M. R., Bakken, T. E., Lake, A. M., Dougherty, J. D., Lein, E. S., Hormozdiari, F., Bernier, R. A., et al. (2019) · Nature Genetics

Genetics and Neurodevelopmental DisordersGenomic variations and chromosomal abnormalities

Cited by 330

PTEN negatively regulates neural stem cell self-renewal by modulating G 0 -G 1 cell cycle entry

Groszer, M., Erickson, R., Scripture-Adams, D. D., Dougherty, J. D., Le Belle, J., Zack, J. A., Geschwind, D. H., Liu, X., Kornblum, H. I., & Wu, H. (2006) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsGlioma Diagnosis and Treatment

Cited by 306

Homologues of the Caenorhabditis elegans Fox-1 Protein Are Neuronal Splicing Regulators in Mammals

Underwood, J. G., Boutz, P. L., Dougherty, J. D., Stoilov, P., & Black, D. L. (2005) · Molecular and Cellular Biology

RNA Research and SplicingRNA regulation and disease

Cited by 272

Astrocytes locally translate transcripts in their peripheral processes

Sakers, K., Lake, A. M., Khazanchi, R., Ouwenga, R., Vasek, M. J., Dani, A., & Dougherty, J. D. (2017) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchRNA Research and Splicing

Cited by 202

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Del-Aguila, J. L., Li, Z., Dube, U., Mihindukulasuriya, K. A., Budde, J. P., Fernandez, M. V., Ibanez, L., Bradley, J., Wang, F., Bergmann, K., et al. (2019) · Alzheimer's Research & Therapy

Single-cell and spatial transcriptomicsAlzheimer's disease research and treatments

Cited by 183

MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts

Abernathy, D. G., Kim, W. K., McCoy, M. J., Lake, A. M., Ouwenga, R., Lee, S. W., Xing, X., Li, D., Lee, H. J., Heuckeroth, R. O., et al. (2017) · Cell Stem Cell

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 145

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum

Araujo, D. J., Anderson, A. G., Berto, S., Runnels, W., Harper, M., Ammanuel, S., Rieger, M. A., Huang, H.-C., Rajkovich, K., Loerwald, K. W., et al. (2015) · Genes & Development

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 111

PBK/TOPK, a Proliferating Neural Progenitor-Specific Mitogen-Activated Protein Kinase Kinase

Dougherty, J. D., Garcia, A. D. R., Nakano, I., Livingstone, M., Norris, B., Polakiewicz, R., Wexler, E. M., Sofroniew, M. V., Kornblum, H. I., & Geschwind, D. H. (2005) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 96

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

Li, Z., Farias, F. H. G., Dube, U., Del-Aguila, J. L., Mihindukulasuriya, K. A., Fernandez, M. V., Ibanez, L., Budde, J. P., Wang, F., Lake, A. M., et al. (2020) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 85

MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models

Hoye, M. L., Koval, E. D., Wegener, A. J., Hyman, T. S., Yang, C., O'Brien, D. R., Miller, R. L., Cole, T., Schoch, K. M., Shen, T., et al. (2017) · The Journal of Neuroscience

Amyotrophic Lateral Sclerosis ResearchMicroRNA in disease regulation

Cited by 82

Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis

Hoye, M. L., Regan, M. R., Jensen, L. A., Lake, A. M., Reddy, L. V., Vidensky, S., Richard, J.-P., Maragakis, N. J., Rothstein, J. D., Dougherty, J. D., et al. (2018) · Brain

Amyotrophic Lateral Sclerosis ResearchMicroRNA in disease regulation

Cited by 63

The female protective effect in autism spectrum disorder is not mediated by a single genetic locus

Gockley, J., Willsey, A. J., Dong, S., Dougherty, J. D., Constantino, J. N., & Sanders, S. J. (2015) · Molecular Autism

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 61

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

The Dominantly Inherited Alzheimer Network (DIAN), Li, Z., Del-Aguila, J. L., Dube, U., Budde, J., Martinez, R., Black, K., Xiao, Q., Cairns, N. J., Dougherty, J. D., et al. (2018) · Genome Medicine

Alzheimer's disease research and treatmentsSingle-cell and spatial transcriptomics

Cited by 56

CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system

Pomper, N., Liu, Y., Hoye, M. L., Dougherty, J. D., & Miller, T. M. (2020) · Scientific Reports

MicroRNA in disease regulationNeuroinflammation and Neurodegeneration Mechanisms

Cited by 39