FoxP1 orchestration of ASD-relevant signaling pathways in the striatum
Open accessAbstract
Mutations in the transcription factor Forkhead box p1 ( FOXP1 ) are causative for neurodevelopmental disorders such as autism. However, the function of FOXP1 within the brain remains largely uncharacterized. Here, we identify the gene expression program regulated by FoxP1 in both human neural cells and patient-relevant heterozygous Foxp1 mouse brains. We demonstrate a role for FoxP1 in the transcriptional regulation of autism-related pathways as well as genes involved in neuronal activity. We show that Foxp1 regulates the excitability of striatal medium spiny neurons and that reduction of Foxp1 correlates with defects in ultrasonic vocalizations. Finally, we demonstrate that FoxP1 has an evolutionarily conserved role in regulating pathways involved in striatal neuron identity through gene expression studies in human neural progenitors with altered FOXP1 levels. These data support an integral role for FoxP1 in regulating signaling pathways vulnerable in autism and the specific regulation of striatal pathways important for vocal communication.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Evidence for enrichment of ASD genes among genes dysregulated in iPSC models of CHD8 or FOXP1 was strongest for genes dysregulated in trans.
“Indeed, evidence for the enrichment of ASD genes amongi genes that are dysregulated in iPSC models of CHD8 (Sugathan et al., 2014) or FOXP1 (Araujo et al., 2015) was strongest for genes that were dysregulated in trans.”
From Getting to the cores of autism (2019) · cites this paper as Araujo et al., 2015
Transcriptomic analysis of developing brain in transgenic mouse models of SETD5, FOXP1, and TBR1 suggests that mutations in these genes lead to dysregulation of ASD genes in trans.
“Similarly transcriptomic analysis of developing brain in transgenic mouse models of SETD5 (Pizzo et al., 2018), FOXP1 (Araujo et al., 2015), TBR1 (Notwell et al., 2016) suggests that mutations in these genes leads to the dysregulation of ASD genes in trans.”
From Getting to the cores of autism (2019) · cites this paper as Araujo et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works
WGCNA: an R package for weighted correlation network analysis
Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252 · see citing works
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696 · see citing works
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,477 · see citing works
A General Framework for Weighted Gene Co-Expression Network Analysis
Zhang, B., & Horvath, S. (2005) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1128 · Cited by 5,684 · see citing works
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572 · see citing works
Self-citationaffy—analysis of Affymetrix GeneChip data at the probe level
Gautier, L., Cope, L., Bolstad, B. M., & Irizarry, R. A. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg405 · Cited by 5,221 · see citing works
RSeQC: quality control of RNA-seq experiments
Wang, L., Wang, S., & Li, W. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts356 · Cited by 2,813 · see citing works
The contribution of de novo coding mutations to autism spectrum disorder
Iossifov, I., O’Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., et al. (2014) · Nature · doi:10.1038/nature13908 · Cited by 2,585 · see citing works
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · see citing works
Spatio-temporal transcriptome of the human brain
Kang, H. J., Kawasawa, Y. I., Cheng, F., Zhu, Y., Xu, X., Li, M., Sousa, A. M. M., Pletikos, M., Meyer, K. A., Sedmak, G., et al. (2011) · Nature · doi:10.1038/nature10523 · Cited by 2,084 · see citing works
FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072 · see citing works
Transcriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology
Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., Mill, J., Cantor, R. M., Blencowe, B. J., & Geschwind, D. H. (2011) · Nature · doi:10.1038/nature10110 · Cited by 1,874 · cited 1× · see citing works
“We also compared the hNPFOXP1 RNA-seq data with two other coexpression modules: asdM12 and asdM16 (derived from human brain tissue samples from ASD cases and controls), which were highly correlated with ASD disease status (Supplemental Table 1; Voineagu et al. 2011).”
ResultStructural Variation of Chromosomes in Autism Spectrum Disorder
Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., Shago, M., Moessner, R., Pinto, D., Ren, Y., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.009 · Cited by 1,815 · see citing works
Modulation of Striatal Projection Systems by Dopamine
Gerfen, C. R., & Surmeier, D. J. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113641 · Cited by 1,700 · see citing works
Unified nomenclature for the winged helix/forkhead transcription factorsPreprint
Kaestner, K. H., Knöchel, W., & Martínez, D. E. (2000) · Genes & Development · doi:10.1101/gad.14.2.142 · Cited by 1,162 · see citing works
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134 · see citing works
Assessing nest building in mice
Deacon, R. M. J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.170 · Cited by 1,115 · see citing works
Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism
Parikshak, N. N., Luo, R., Zhang, A., Won, H., Lowe, J. K., Chandran, V., Horvath, S., & Geschwind, D. H. (2013) · Cell · doi:10.1016/j.cell.2013.10.031 · Cited by 1,039 · see citing works
Is My Network Module Preserved and Reproducible?
Langfelder, P., Luo, R., Oldham, M. C., & Horvath, S. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1001057 · Cited by 1,012 · see citing works
ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments
Lachmann, A., Xu, H., Krishnan, J., Berger, S., Mazloom, A. R., & Ma’ayan, A. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq466 · Cited by 997 · see citing works
Rogers, D. C., Fisher, E. M. C., Brown, S. D. M., Peters, J., Hunter, A. J., & Martin, J. E. (1997) · Mammalian Genome · doi:10.1007/s003359900551 · Cited by 795 · see citing works
Functional organization of the transcriptome in human brain
Oldham, M. C., Konopka, G., Iwamoto, K., Langfelder, P., Kato, T., Horvath, S., & Geschwind, D. H. (2008) · Nature Neuroscience · doi:10.1038/nn.2207 · Cited by 752 · cited 1× · see citing works
“2A; Zhang and Horvath 2005; Oldham et al. 2008).”
BackgroundSelf-citationThalamocortical responses of mouse somatosensory (barrel) cortexin vitro
Agmon, A., & Connors, B. W. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90333-j · Cited by 673 · see citing works
Holy, T. E., & Guo, Z. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030386 · Cited by 673 · see citing works
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S. M., Blass, T., Somel, M., Brückner, M. K., Schreiweis, C., Winter, C., Sohr, R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.041 · Cited by 605 · see citing works
FOXP2 as a molecular window into speech and language
Fisher, S. E., & Scharff, C. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.03.002 · Cited by 541 · see citing works
The translation of translational control by FMRP: therapeutic targets for FXS
Darnell, J. C., & Klann, E. (2013) · Nature Neuroscience · doi:10.1038/nn.3379 · Cited by 491 · see citing works
Gene hunting in autism spectrum disorder: on the path to precision medicine
Geschwind, D. H., & State, M. W. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00044-7 · Cited by 481 · see citing works
Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain
Ferland, R. J., Cherry, T. J., Preware, P. O., Morrisey, E. E., & Walsh, C. A. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10654 · Cited by 477 · see citing works
Scattoni, M. L., Crawley, J. N., & Ricceri, L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.003 · Cited by 473 · see citing works
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Parikshak, N. N., Gandal, M. J., & Geschwind, D. H. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3934 · Cited by 430 · cited 1× · see citing works
“Furthermore, many autismrisk genes are thought to exert their effects during early brain development (State and Sestan 2012; Xu et al. 2014; Parikshak et al. 2015).”
BackgroundAltered ultrasonic vocalization in mice with a disruption in the Foxp2 gene
Shu, W., Cho, J. Y., Jiang, Y., Zhang, M., Weisz, D. J., Elder, G. A., Schmeidler, J., Gasperi, R. D., Sosa, M. A. G., Rabidou, D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503739102 · Cited by 415 · see citing works
Human-specific transcriptional regulation of CNS development genes by FOXP2
Konopka, G., Bomar, J. M., Winden, K., Coppola, G., Jonsson, Z. O., Gao, F., Peng, S., Preuss, T. M., Wohlschlegel, J. A., & Geschwind, D. H. (2009) · Nature · doi:10.1038/nature08549 · Cited by 390 · see citing works
Dasen, J. S., De Camilli, A., Wang, B., Tucker, P. W., & Jessell, T. M. (2008) · Cell · doi:10.1016/j.cell.2008.06.019 · Cited by 376 · see citing works
Li, S., Weidenfeld, J., & Morrisey, E. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.809-822.2004 · Cited by 333 · see citing works
Foxp1 is an essential transcriptional regulator of B cell development
Hu, H., Wang, B., Borde, M., Nardone, J., Maika, S. D., Allred, L., Tucker, P. W., & Rao, A. (2006) · Nature Immunology · doi:10.1038/ni1358 · Cited by 326 · see citing works
Klassen, T. L., Davis, C., Goldman, A., Burgess, D., Chen, T., Wheeler, D., Mcpherson, J., Bourquin, T., Lewis, L. R., Villasana, D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.05.025 · Cited by 299 · see citing works
Foxp2 and Foxp1 cooperatively regulate lung and esophagus development
Shu, W., Lu, M. M., Zhang, Y., Tucker, P. W., Zhou, D., & Morrisey, E. E. (2007) · Development · doi:10.1242/dev.02846 · Cited by 296 · see citing works
Ellegood, J., Anagnostou, E., Babineau, B. A., Crawley, J. N., Lin, L., Genestine, M., DiCicco-Bloom, E., Lai, J. K. Y., Foster, J. A., Peñagarikano, O., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.98 · Cited by 288 · see citing works
Spiteri, E., Konopka, G., Coppola, G., Bomar, J. M., Oldham, M. C., Ou, J., Vernes, S. C., Fisher, S. E., Ren, B., & Geschwind, D. H. (2007) · The American Journal of Human Genetics · doi:10.1086/522237 · Cited by 281 · see citing works
Self-citationFoxp2 regulates gene networks implicated in neurite outgrowth in the developing brain
Vernes, S. C., Oliver, P. L., Spiteri, E., Lockstone, H. E., Puliyadi, R., Taylor, J. M., Ho, J., Mombereau, C., Brewer, A., Lowy, E., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002145 · Cited by 276 · see citing works
Xu, X., Wells, A., O’Brien, D. R., Nehorai, A., & Dougherty, J. D. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4488-13.2014 · Cited by 271 · see citing works
Self-citationKim, J., Wei, D., & Hoffman, D. A. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.095042 · Cited by 266 · see citing works
Rousso, D. L., Gaber, Z. B., Wellik, D. M., Morrisey, E. E., & Novitch, B. G. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.025 · Cited by 254 · see citing works
Wang, B., Weidenfeld, J., Lu, M. M., Maika, S. D., Kuziel, W. A., Morrisey, E. E., & Tucker, P. W. (2004) · Development · doi:10.1242/dev.01287 · Cited by 248 · see citing works
Multiple Testing Procedures: the multtest Package and Applications to Genomics
Pollard, K. S., Dudoit, S., & van der Laan, M. J. (2005) · Statistics in the health sciences · doi:10.1007/0-387-29362-0_15 · Cited by 241 · see citing works
PeakAnalyzer: Genome-wide annotation of chromatin binding and modification loci
Salmon‐Divon, M., Dvinge, H., Koort, K., & Bertone, P. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-415 · Cited by 238 · see citing works
Wang, B., Lin, D., Li, C., & Tucker, P. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207174200 · Cited by 231 · see citing works
Structure of the Forkhead Domain of FOXP2 Bound to DNA
Stroud, J. C., Wu, Y., Bates, D. L., Han, A., Nowick, K., Pääbo, S., Tong, H., & Chen, L. (2006) · Structure · doi:10.1016/j.str.2005.10.005 · Cited by 205 · see citing works
A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells
Stein, J. L., de la Torre-Ubieta, L., Tian, Y., Parikshak, N. N., Hernández, I. A., Marchetto, M. C., Baker, D. K., Lu, D., Hinman, C. R., Lowe, J. K., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.035 · Cited by 201 · see citing works
Rousso, D. L., Pearson, C. A., Gaber, Z. B., Miquelajáuregui, A., Li, S., Portera‐Cailliau, C., Morrisey, E. E., & Novitch, B. G. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.024 · Cited by 180 · see citing works
Autism spectrum disorder in fragile X syndrome: a longitudinal evaluation
Hernandez, R. N., Feinberg, R. L., Vaurio, R., Passanante, N. M., Thompson, R. E., & Kaufmann, W. E. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32848 · Cited by 178 · see citing works
Ade, K. K., Wan, Y., Chen, M., Gloss, B. R., & Calakos, N. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00032 · Cited by 175 · see citing works
Abnormal Striatal GABA Transmission in the Mouse Model for the Fragile X Syndrome
Centonze, D., Rossi, S., Mercaldo, V., Napoli, I., Ciotti, M. T., De Chiara, V., Musella, A., Prosperetti, C., Calabresi, P., Bernardi, G., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.008 · Cited by 171 · see citing works
The Emerging Biology of Autism Spectrum Disorders
State, M. W., & Šestan, N. (2012) · Science · doi:10.1126/science.1224989 · Cited by 164 · see citing works
Gross, C., Yao, X., Pong, D. L., Jeromin, A., & Bassell, G. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6661-10.2011 · Cited by 161 · see citing works
Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour
Bacon, C., Schneider, M., Le Magueresse, C., Froehlich, H., Sticht, C., Gluch, C., Monyer, H., & Rappold, G. A. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.116 · Cited by 148 · see citing works
The Human Language–Associated Gene SRPX2 Regulates Synapse Formation and Vocalization in Mice
Sia, G.-M., Clem, R. L., & Huganir, R. L. (2013) · Science · doi:10.1126/science.1245079 · Cited by 147 · see citing works
The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders
Bacon, C., & Rappold, G. (2012) · Human Genetics · doi:10.1007/s00439-012-1193-z · Cited by 139 · see citing works
VisANT 4.0: Integrative network platform to connect genes, drugs, diseases and therapies
Hu, Z., Chang, Y.-C., Wang, Y., Huang, C. L., Liu, Y., Tian, F., Granger, B. R., & DeLisi, C. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt401 · Cited by 130 · see citing works
Hisaoka, T., Nakamura, Y. K., Senba, E., & Morikawa, Y. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.055 · Cited by 120 · see citing works
Lee, H., Lin, M., Kornblum, H. I., Papazian, D. M., & Nelson, S. F. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu056 · Cited by 119 · see citing works
French, C. A., Jin, X., Campbell, T. G., Gerfen, E., Groszer, M., Fisher, S. E., & Costa, R. M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.105 · Cited by 105 · see citing works
G9a influences neuronal subtype specification in striatum
Maze, I. S., Chaudhury, D., Dietz, D., von Schimmelmann, M. J., Kennedy, P., Lobo, M. K., Daws, S. E., Miller, M. L., Bagot, R. C., Sun, H., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3670 · Cited by 91 · see citing works
Roy, S., Watkins, N. W., & Heck, D. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044816 · Cited by 87 · see citing works
Modeling the functional genomics of autism using human neurons
Konopka, G., Wexler, E., Rosen, E., Mukamel, Z., Osborn, G. E., Chen, L., Lu, D., Gao, F., Gao, K., Lowe, J. K., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.60 · Cited by 76 · see citing works
Self-citationFOXP2 as a molecular window into speech and language
Fisher, S. E. (2013) · Cited by 69 · see citing works
Parallel FoxP1 and FoxP2 Expression in Songbird and Human Brain Predicts Functional Interaction
Teramitsu, I., Kudo, L., London, S. E., Geschwind, D., & White, S. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5589-03.2004 · Cited by 64 · see citing works
Increased gene expression of FOXP1 in patients with autism spectrum disorders
Chien, W., Gau, S. S., Chen, C., Tsai, W., Wu, Y.-Y., Chen, P., Shang, C., & Chen, C. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-23 · Cited by 62 · see citing works
Tang, B., Bečanović, K., Desplats, P., Spencer, B. J., Hill, A. M., Connolly, C., Masliah, E., Leavitt, B. R., & Thomas, E. A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds132 · Cited by 58 · see citing works
Grant, L. M., Richter, F., Miller, J. E., White, S. A., Fox, C., Zhu, C., Chesselet, M., & Ciucci, M. R. (2014) · Behavioral Neuroscience · doi:10.1037/a0035965 · Cited by 51 · see citing works
Sex-Dependent Changes in Social Behaviors in Motor Pre-Symptomatic R6/1 Mice
Pietropaolo, S., Delage, P., Cayzac, S., Crusio, W. E., & Cho, Y. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019965 · Cited by 40 · see citing works
Curry, T., Egeto, P., Wang, H., Podnos, A., Wasserman, D., & Yeomans, J. S. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12037 · Cited by 34 · see citing works
Foeger, N. C., Norris, A. J., Wren, L., & Nerbonne, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324574 · Cited by 34 · see citing works
Ouwenga, R., & Dougherty, J. D. (2015) · Molecular Autism · doi:10.1186/s13229-015-0008-1 · Cited by 31 · see citing works
Self-citationIdentifying Essential Cell Types and Circuits in Autism Spectrum Disorders
Maloney, S. E., Rieger, M. A., & Dougherty, J. D. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-418700-9.00003-4 · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Getting to the cores of autism
Iakoucheva, L. M., Muotri, A. R., & Sebat, J. (2019) · Cell · doi:10.1016/j.cell.2019.07.037 · Cited by 260 · see citing works
“, 2014) or FOXP1 (Araujo et al., 2015) was strongest for genes that were dysregulated in trans (i.”
BackgroundInfluentialFOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging
Li, H., Liu, P., Xu, S., Li, Y., Dekker, J. D., Li, B., Fan, Y., Zhang, Z., Hong, Y., Yang, G., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89511 · Cited by 180 · see citing works
Celen, C., Chuang, J.-C., Luo, X., Nijem, N., Walker, A. K., Chen, F., Zhang, S., Chung, A. S., Nguyen, L. H., Nassour, I., et al. (2017) · eLife · doi:10.7554/elife.25730 · Cited by 113 · see citing works
Araujo, D. J., Toriumi, K., Escamilla, C. O., Kulkarni, A., Anderson, A. G., Harper, M., Usui, N., Ellegood, J., Lerch, J. P., Birnbaum, S. G., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.1005-17.2017 · Cited by 73 · see citing works
Self-citationThe 22q11.2 region regulates presynaptic gene-products linked to schizophrenia
Nehme, R., Pietiläinen, O., Artomov, M., Tegtmeyer, M., Valakh, V., Lehtonen, L., Bell, C., Singh, T., Trehan, A., Sherwood, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31436-8 · Cited by 58 · see citing works
- Authors
- Araujo, D. J., Anderson, A. G., Berto, S., Runnels, W., Harper, M., Ammanuel, S., Rieger, M. A., Huang, H.-C., Rajkovich, K., Loerwald, K. W., Dekker, J. D., Tucker, H. O., Dougherty, J. D., Gibson, J. R., & Konopka, G.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Washington University in St. Louis (US)
- Jackson State University (US)
- The University of Texas at Austin (US)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-10-15
- Volume
- 29
- Issue
- 20
- Pages
- 2081-2096
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC4617974
- OpenAlex
- W2120966119
- Cited by
- 111
- References
- 82
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 9 · 2023: 11 · 2022: 11 · 2021: 18 · 2020: 6 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 6
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Genes & Development (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Funders
- National Science Foundation (2013162469)
- National Institutes of Health (T32MH076690, T32GM007067, R01CA31534, R00MH090238, R01MH102603)
- Lymphoma Foundation
- Cancer Prevention Research Institute of Texas (RP100612, RP120348)
- Marie Betzner Morrow Centennial Endowment
- McDonnell Center for Systems Neuroscience
- March of Dimes Foundation (5-FY13-19)
- Once Upon a Time Foundation
- Autism Research at University of Texas Southwestern Endowment
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Keywords
- FOXP1, autism spectrum disorder, striatum, medium spiny neurons, neuronal excitability, ultrasonic vocalizations, vocal communication, transcriptional regulation, neuronal identity, neurodevelopmental disorders
- MeSH terms
- Autism Spectrum Disorder, Animals, Cells, Cultured, Corpus Striatum, Disease Models, Animal, Gene Expression Regulation, Hippocampus, Humans, Mice, Inbred C57BL, Mutation, Neurons, Repressor Proteins, Verbal Behavior, Signal Transduction, Mice, Forkhead Transcription Factors, Haploinsufficiency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
