Mann, Derek A.

Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., et al. (2017) · Nature Communications

Telomeres, Telomerase, and SenescenceLiver Disease Diagnosis and Treatment

Cited by 1,044

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., Saretzki, G., Fox, C., Lawless, C., Anderson, R., et al. (2014) · Nature Communications

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 819

Mitochondria are required for pro-ageing features of the senescent phenotype

Correia‐Melo, C., Marques, F. D., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B. M., Miwa, S., Birch, J., Merz, A., et al. (2016) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 796

Clinical evidence for the regression of liver fibrosis

Ellis, E. L., & Mann, D. A. (2012) · Journal of Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 411

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., et al. (2019) · Nature Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 398

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

Mann, J., Chu, D. C. K., Maxwell, A., Oakley, F., Zhu, N., Tsukamoto, H., & Mann, D. A. (2010) · Gastroenterology

Liver physiology and pathologyEpigenetics and DNA Methylation

Cited by 397

Multigenerational epigenetic adaptation of the hepatic wound-healing response

Zeybel, M., Hardy, T., Wong, Y. K., Mathers, J. C., Fox, C. R., Gackowska, A., Oakley, F., Burt, A. D., Wilson, C. L., Anstee, Q. M., et al. (2012) · Nature Medicine

Liver physiology and pathologyEpigenetics and DNA Methylation

Cited by 279

Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease

Ebrahimkhani, M. R., Oakley, F., Murphy, L. B., Mann, J., Moles, A., Perugorria, M. J., Ellis, E., Lakey, A. F., Burt, A. D., Douglass, A., et al. (2011) · Nature Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 221

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

Hardy, T., Zeybel, M., Day, C. P., Dipper, C., Masson, S., McPherson, S., Henderson, E., Tiniakos, D., White, S., French, J., et al. (2017) · Gut

Liver Disease Diagnosis and TreatmentEpigenetics and DNA Methylation

Cited by 216

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Lagnado, A., Leslie, J., Ruchaud‐Sparagano, M., Victorelli, S., Hirsova, P., Ogrodnik, M., Collins, A. L., Vizioli, M. G., Habiballa, L., Saretzki, G., et al. (2021) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 211

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma

Wilson, C. L., Jurk, D., Fullard, N., Banks, P., Page, A., Luli, S., Elsharkawy, A. M., Gieling, R. G., Chakraborty, J. B., Fox, C., et al. (2015) · Nature Communications

Immune cells in cancerHepatocellular Carcinoma Treatment and Prognosis

Cited by 171

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., et al. (2014) · Journal of Hepatology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 169

The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes

Elsharkawy, A. M., Oakley, F., Lin, F., Packham, G., Mann, D. A., & Mann, J. (2010) · Journal of Hepatology

NF-κB Signaling PathwaysLiver physiology and pathology

Cited by 160

Epigenetics in liver disease

Mann, D. A. (2014) · Hepatology

Epigenetics and DNA MethylationLiver physiology and pathology

Cited by 153

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

Perugorria, M. J., Esparza-Baquer, A., Oakley, F., Labiano, I., Korosec, A., Jais, A., Mann, J., Tiniakos, D., Santos-Laso, A., Arbelaiz, A., et al. (2019) · Gut

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 144

Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury

Oakley, F., Mann, J., Nailard, S., Smart, D. E., Mungalsingh, N., Constandinou, C., Ali, S., Wilson, S. J., Millward-Sadler, H., Iredale, J. P., et al. (2005) · The American Journal of Pathology

Liver physiology and pathologyNF-κB Signaling Pathways

Cited by 123

Novel therapeutic targets in primary biliary cirrhosis

Dyson, J. K., Hirschfield, G. M., Adams, D. H., Beuers, U., Mann, D. A., Lindor, K. D., & Jones, D. E. J. (2015) · Nature Reviews Gastroenterology & Hepatology

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 120

Transcriptional regulation of hepatic stellate cells

Mann, J., & Mann, D. A. (2009) · Advanced Drug Delivery Reviews

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 119

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision‐Cut Liver Slices

Paish, H. L., Reed, L. H., Brown, H., Bryan, M. C., Govaere, O., Leslie, J., Barksby, B. S., Garcia Macia, M., Watson, A., Xu, X., et al. (2019) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 106

TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation

Labiano, I., Agirre-Lizaso, A., Olaizola, P., Echebarria, A., Huici-Izagirre, M., Olaizola, I., Esparza-Baquer, A., Sharif, O., Hijona, E., Milkiewicz, P., et al. (2022) · Journal of Hepatology

Liver Diseases and ImmunityLiver physiology and pathology

Cited by 78

Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice

Correia‐Melo, C., Birch, J., Fielder, E., Rahmatika, D., Taylor, J., Chapman, J., Lagnado, A., Carroll, B. M., Miwa, S., Richardson, G., et al. (2019) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 77

Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice

Fielder, E., Tweedy, C., Wilson, C., Oakley, F., LeBeau, F. E. N., Passos, J. F., Mann, D. A., von Zglinicki, T., & Jurk, D. (2020) · Aging Cell

Neuroinflammation and Neurodegeneration MechanismsAntioxidants, Aging, Portulaca oleracea

Cited by 71

Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach

Brennan, P. N., Elsharkawy, A. M., Kendall, T. J., Loomba, R., Mann, D. A., & Fallowfield, J. A. (2023) · Nature Reviews Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 68

Hepatic Nuclear Factor κB Regulates Neutrophil Recruitment to the Injured Brain

Campbell, S. J., Anthony, D. C., Oakley, F., Carlsen, H., Elsharkawy, A. M., Blomhoff, R., & Mann, D. A. (2008) · Journal of Neuropathology & Experimental Neurology

NF-κB Signaling PathwaysTraumatic Brain Injury and Neurovascular Disturbances

Cited by 67