Barford, David

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

Salmeen, A., Andersen, J. N., Myers, M. P., Meng, T.-C., Hinks, J. A., Tonks, N. K., & Barford, D. (2003) · Nature

Protein Tyrosine PhosphatasesRedox biology and oxidative stress

Cited by 951

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

Groves, M. R., Hanlon, N., Turowski, P., Hemmings, B. A., & Barford, D. (1999) · Cell

Protein Structure and DynamicsProtein Tyrosine Phosphatases

Cited by 442

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2

Barford, D., & Neel, B. G. (1998) · Structure

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 321

Molecular mechanism of APC/C activation by mitotic phosphorylation

Zhang, S., Chang, L., Alfieri, C., Zhang, Z., Yang, J., Maslen, S., Skehel, M., & Barford, D. (2016) · Nature

Microtubule and mitosis dynamicsUbiquitin and proteasome pathways

Cited by 203

Activation of Rho GTPases by DOCK Exchange Factors Is Mediated by a Nucleotide Sensor

Yang, J., Zhang, Z., Roe, S. M., Marshall, C. J., & Barford, D. (2009) · Science

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 123

Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome

Yatskevich, S., Muir, K. W., Bellini, D., Zhang, Z., Yang, J., Tischer, T., Predin, M., Dendooven, T., McLaughlin, S. H., & Barford, D. (2022) · Science

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 120

Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome

Yatskevich, S., Muir, K. W., Bellini, D., Zhang, Z., Yang, J., Tischer, T., Predin, M., Dendooven, T., McLaughlin, S. H., & Barford, D. (2022) · Science

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 120

Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors

Kulkarni, K., Yang, J., Zhang, Z., & Barford, D. (2011) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 97

Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

Chang, L., Yang, J., Jo, C. H., Boland, A., Zhang, Z., McLaughlin, S. H., Abu-Thuraia, A., Killoran, R. C., Smith, M. J., Côté, J.-F., et al. (2020) · Nature Communications

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 59

Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere

Dendooven, T., Zhang, Z., Yang, J., McLaughlin, S. H., Schwab, J., Scheres, S. H. W., Yatskevich, S., & Barford, D. (2022) · Science Advances

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 58

Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere

Dendooven, T., Zhang, Z., Yang, J., McLaughlin, S. H., Schwab, J., Scheres, S. H. W., Yatskevich, S., & Barford, D. (2023) · Science Advances

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 58

Structure of the human outer kinetochore KMN network complex

Yatskevich, S., Yang, J., Bellini, D., Zhang, Z., & Barford, D. (2024) · Nature Structural & Molecular Biology

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 42

Structure of the native γ-Tubulin Ring Complex capping spindle microtubules

Barford, D., Dendooven, T., Yatskevich, S., Burt, A., Bellini, D., & Kilmartin, J. (2023) · Nature Structural & Molecular Biology

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 38

Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules

Muir, K. W., Batters, C., Dendooven, T., Yang, J., Zhang, Z., Burt, A., & Barford, D. (2023) · Science

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 34

Cryo-EM structures of apo-APC/C and APC/CCDH1:EMI1 complexes provide insights into APC/C regulation

Höfler, A., Yu, J., Yang, J., Zhang, Z., Chang, L., McLaughlin, S. H., Grime, G. W., Garman, E. F., Boland, A., & Barford, D. (2024) · Nature Communications

Microtubule and mitosis dynamicsUbiquitin and proteasome pathways

Cited by 18

New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/CCDH1:EMI1 complex

Barford, D., Höfler, A., Yu, J., Yan, J., Zhang, Z., Chang, L., Grime, G., Garman, E., & Boland, A. (2023) · Nature Communications

Microtubule and mitosis dynamicsUbiquitin and proteasome pathways

Cited by 18

A comparative study of the cryo-EM structures of Saccharomyces cerevisiae and human anaphase-promoting complex/cyclosome (APC/C)

Vazquez-Fernandez, E., Yang, J., Zhang, Z., Andreeva, A. E., Emsley, P., & Barford, D. (2024) · eLife

Ubiquitin and proteasome pathwaysMicrotubule and mitosis dynamics

Cited by 8

A comparative study of the cryo-EM structures of S. cerevisiae and human anaphase-promoting complex/cyclosome (APC/C)

Vazquez-Fernandez, E., Yang, J., Zhang, Z., Andreeva, A. E., Emsley, P., & Barford, D. (2024) · eLife

Ubiquitin and proteasome pathwaysMicrotubule and mitosis dynamics

Cited by 8