Seabra, Miguel C.

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

MacLaren, R. E., Groppe, M., Barnard, A. R., Cottriall, C. L., Tolmachova, T., Seymour, L., Clark, K. R., During, M. J., Cremers, F. P. M., Black, G. C. M., et al. (2014) · The Lancet

Retinal Development and DisordersVirus-based gene therapy research

Cited by 796

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

Alexander, M., Hu, R., Runtsch, M. C., Kagele, D. A., Mosbruger, T. L., Tolmachova, T., Seabra, M. C., Round, J. L., Ward, D. M., & O’Connell, R. M. (2015) · Nature Communications

Extracellular vesicles in diseaseMicroRNA in disease regulation

Cited by 769

Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase

Seabra, M. C., Brown, M. S., & Goldstein, J. L. (1993) · Science

Retinal Development and DisordersCellular transport and secretion

Cited by 337

A Family of Rab27-binding Proteins

Strom, M., Hume, A. N., Tarafder, A. K., Barkagianni, E., & Seabra, M. C. (2002) · Journal of Biological Chemistry

Cellular transport and secretionCalcium signaling and nucleotide metabolism

Cited by 324

Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product

Seabra, M. C., Brown, M. S., Slaughter, C. A., Südhof, T. C., & Goldstein, J. L. (1992) · Cell

Cellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Cited by 300

Membrane Association and Targeting of Prenylated Ras-like GTPases

Seabra, M. C. (1998) · Cellular Signalling

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 261

Deficient geranylgeranylation of Ram/Rab27 in choroideremia

Seabra, M. C., Ho, Y. K., & Anant, J. S. (1995) · Journal of Biological Chemistry

Retinal Development and DisordersCellular transport and secretion

Cited by 223

Visual Acuity after Retinal Gene Therapy for Choroideremia

Edwards, T. L., Jolly, J. K., Groppe, M., Barnard, A. R., Cottriall, C. L., Tolmachova, T., Black, G. C., Webster, A. R., Lotery, A. J., Holder, G. E., et al. (2016) · New England Journal of Medicine

Retinal Development and DisordersVirus-based gene therapy research

Cited by 195

Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia

Xue, K., Jolly, J. K., Barnard, A. R., Rudenko, A., Salvetti, A. P., Patrício, M. I., Edwards, T. L., Groppe, M., Orlans, H. O., Tolmachova, T., et al. (2018) · Nature Medicine

Retinal Development and DisordersVirus-based gene therapy research

Cited by 185

Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia: The Alberta Experience

Dimopoulos, I. S., Hoang, S. C., Radziwon, A., Binczyk, N. M., Seabra, M. C., MacLaren, R. E., Somani, R., Tennant, M. T. S., & MacDonald, I. M. (2018) · American Journal of Ophthalmology

Retinal Development and DisordersVirus-based gene therapy research

Cited by 175

Melanin Transfer in the Epidermis: The Pursuit of Skin Pigmentation Control Mechanisms

Moreiras, H., Seabra, M. C., & Barral, D. C. (2021) · International Journal of Molecular Sciences

melanin and skin pigmentationMelanoma and MAPK Pathways

Cited by 147

Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis

Tarafder, A. K., Bolasco, G., Correia, M. S., Pereira, F. J. C., Iannone, L., Hume, A. N., Kirkpatrick, N., Picardo, M., Torrisi, M. R., Rodrigues, I. P., et al. (2014) · Journal of Investigative Dermatology

melanin and skin pigmentationCellular transport and secretion

Cited by 128

Melanin's Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing

Bento-Lopes, L., Cabaço, L. C., Charneca, J., Neto, M. V., Seabra, M. C., & Barral, D. C. (2023) · International Journal of Molecular Sciences

melanin and skin pigmentationMelanoma and MAPK Pathways

Cited by 114

The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells

Futter, C. E., Ramalho, J. S., Jaissle, G. B., Seeliger, M. W., & Seabra, M. C. (2004) · Molecular Biology of the Cell

melanin and skin pigmentationRetinal Development and Disorders

Cited by 110

Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes

Hume, A. N., Ushakov, D. S., Tarafder, A. K., Ferenczi, M. A., & Seabra, M. C. (2007) · Journal of Cell Science

melanin and skin pigmentationCellular transport and secretion

Cited by 103

The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium

Lopes, V. S., Ramalho, J. S., Owen, D. M., Karl, M. O., Strauss, O., Futter, C. E., & Seabra, M. C. (2007) · Traffic

Cellular transport and secretionmelanin and skin pigmentation

Cited by 95

Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments

Correia, M. S., Moreiras, H., Pereira, F. J. C., Neto, M. V., Festas, T. C., Tarafder, A. K., Ramalho, J. S., Seabra, M. C., & Barral, D. C. (2018) · Journal of Investigative Dermatology

melanin and skin pigmentationCellular transport and secretion

Cited by 72

Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL

Burgoyne, T., O'Connor, M. N., Seabra, M. C., Cutler, D. F., & Futter, C. E. (2015) · Journal of Cell Science

melanin and skin pigmentationRetinal Development and Disorders

Cited by 68

Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium

Wavre-Shapton, S. T., Tolmachova, T., da Silva, M. L., Futter, C. E., & Seabra, M. C. (2013) · PLoS ONE

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 67

Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium

Wavre-Shapton, S. T., Meschede, I. P., Seabra, M. C., & Futter, C. E. (2014) · Journal of Cell Science

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 60

Retinal Progression Biomarkers of Early and Intermediate Age-Related Macular Degeneration

Flores, R., Carneiro, Â., Tenreiro, S., & Seabra, M. C. (2021) · Life

Retinal Diseases and TreatmentsRetinal Imaging and Analysis

Cited by 42

Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer

Hall, M. J., Lopes‐Ventura, S., Neto, M. V., Charneca, J., Zoio, P., Seabra, M. C., Oliva, A., & Barral, D. C. (2022) · Pigment Cell & Melanoma Research

melanin and skin pigmentationMelanoma and MAPK Pathways

Cited by 39

Deacidification of endolysosomes by neuronal aging drives synapse loss

Burrinha, T., Cunha, C., Hall, M. J., Lopes‐da‐Silva, M., Seabra, M. C., & Guimas Almeida, C. (2023) · Traffic

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 35

Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalization

Moreiras, H., Bento‐Lopes, L., Neto, M. V., Escrevente, C., Cabaço, L. C., Hall, M. J., Ramalho, J. S., Seabra, M. C., & Barral, D. C. (2022) · Traffic

melanin and skin pigmentationCellular transport and secretion

Cited by 34