Lehár, Joseph

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature

Cancer Genomics and DiagnosticsComputational Drug Discovery Methods

Cited by 7,950

Multi-target therapeutics: when the whole is greater than the sum of the parts

Zimmermann, G. R., Lehár, J., & Keith, C. T. (2007) · Drug Discovery Today

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 1,105

Systematic discovery of multicomponent therapeutics

Borisy, A. A., Elliott, P. J., Hurst, N. W., Lee, M. S., Lehár, J., Price, E. R., Serbedzija, G., Zimmermann, G. R., Foley, M. A., Stockwell, B. R., et al. (2003) · Proceedings of the National Academy of Sciences

Computational Drug Discovery MethodsHistorical Medical Research and Treatments

Cited by 620

Chemical combination effects predict connectivity in biological systems

Lehár, J., Zimmermann, G. R., Krueger, A. S., Molnar, R. A., Ledell, J. T., Heilbut, A. M., Short, G. F., Giusti, L. C., Nolan, G. P., Magid, O. A., et al. (2007) · Molecular Systems Biology

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 275

Combination chemical genetics

Lehár, J., Stockwell, B. R., Giaever, G., & Nislow, C. (2008) · Nature Chemical Biology

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 172

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection

Suzuki, Y., Onge, R. P. S., Mani, R., King, O. D., Heilbut, A., Labunskyy, V. M., Chen, W., Pham, L., Zhang, L. V., Tong, A. H. Y., et al. (2011) · Nature Methods

Fungal and yeast genetics researchDrug Transport and Resistance Mechanisms

Cited by 78