Ryu, Jae Kyu

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

Petersen, M. A., Ryu, J. K., & Akassoglou, K. (2018) · Nature reviews. Neuroscience

Barrier Structure and Function StudiesBlood properties and coagulation

Cited by 527

Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an Alzheimer's disease model

Merlini, M., Rafalski, V. A., Rios Coronado, P. E., Gill, T. M., Ellisman, M., Muthukumar, G., Subramanian, K. S., Ryu, J. K., Syme, C. A., Davalos, D., et al. (2019) · Neuron

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 431

A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

Ryu, J. K., & McLarnon, J. G. (2009) · Journal of Cellular and Molecular Medicine

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 406

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

Xu, T., Stewart, K. M., Wang, X., Liu, K., Xie, M., Ryu, J. K., Li, K., Ma, T., Wang, H., Ni, L., et al. (2017) · Nature

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 395

Upregulated Expression of Purinergic P2X 7 Receptor in Alzheimer Disease and Amyloid-β Peptide-Treated Microglia and in Peptide-Injected Rat Hippocampus

McLarnon, J. G., Ryu, J. K., Walker, D. G., & Choi, H. B. (2006) · Journal of Neuropathology & Experimental Neurology

Adenosine and Purinergic SignalingAlzheimer's disease research and treatments

Cited by 281

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Ryu, J. K., Petersen, M. A., Murray, S. G., Baeten, K. M., Meyer-Franke, A., Chan, J. P., Vagena, E., Bedard, C., Machado, M. R., Coronado, P. E. R., et al. (2015) · Nature Communications

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 271

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Ryu, J. K., Rafalski, V. A., Meyer-Franke, A., Adams, R. A., Poda, S. B., Rios Coronado, P. E., Pedersen, L. Ø., Menon, V., Baeten, K. M., Sikorski, S. L., et al. (2018) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 213

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Mendiola, A. S., Ryu, J. K., Bardehle, S., Meyer-Franke, A., Ang, K. K.-H., Wilson, C., Baeten, K. M., Hanspers, K., Merlini, M., Thomas, S., et al. (2020) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 199

Modulation of the Purinergic P2X7Receptor Attenuates Lipopolysaccharide-Mediated Microglial Activation and Neuronal Damage in Inflamed Brain

Choi, H. B., Ryu, J. K., Kim, S. U., & McLarnon, J. G. (2007) · The Journal of Neuroscience

Adenosine and Purinergic SignalingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 173

Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimer's disease

Ryu, J. K., & McLarnon, J. G. (2008) · NeuroReport

Adenosine and Purinergic SignalingAlzheimer's disease research and treatments

Cited by 134

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

Czirr, E., Castello, N. A., Mosher, K. I., Castellano, J. M., Hinkson, I. V., Lucin, K. M., Baeza-Raja, B., Ryu, J. K., Li, L., Farina, S. N., et al. (2017) · Journal of Experimental Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 126

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

Mendiola, A. S., Yan, Z., Dixit, K., Johnson, J. R., Bouhaddou, M., Meyer-Franke, A., Shin, M.-G., Yong, Y., Agrawal, A., MacDonald, E., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 124

Microglial VEGF Receptor Response Is an Integral Chemotactic Component in Alzheimer's Disease Pathology

Ryu, J. K., Cho, T., Choi, H. B., Wang, Y. T., & McLarnon, J. G. (2009) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 121

Fibrin drives thromboinflammation and neuropathology in COVID-19

Ryu, J. K., Yan, Z., Montano, M., Sozmen, E. G., Dixit, K., Suryawanshi, R. K., Matsui, Y., Helmy, E., Kaushal, P., Makanani, S. K., et al. (2024) · Nature

COVID-19 Clinical Research StudiesBlood properties and coagulation

Cited by 116

Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum

Ryu, J. K., Choi, H. B., & McLarnon, J. G. (2005) · Neurobiology of Disease

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 93

Inhibition of lipopolysaccharide‐induced cyclooxygenase‐2, tumor necrosis factor‐α and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195

Choi, H. B., Khoo, C., Ryu, J. K., Van Breemen, E., Kim, S. U., & McLarnon, J. G. (2002) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsPharmacological Receptor Mechanisms and Effects

Cited by 82

Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington’s disease

Ryu, J. K., Kim, S. U., & McLarnon, J. G. (2004) · Experimental Neurology

Genetic Neurodegenerative DiseasesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 62