Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

Cytoscape: A software Environment for integrated models of biomolecular interaction networks

Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888 · see citing works

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259 · see citing works

Comprehensive Integration of Single-Cell Data

Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453 · see citing works

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Zhou, Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, A. H., Tanaseichuk, O., Benner, C., & Chanda, S. K. (2019) · Nature Communications · doi:10.1038/s41467-019-09234-6 · Cited by 14,611 · see citing works

Fast, sensitive and accurate integration of single-cell data with Harmony

Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488 · see citing works

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

Szklarczyk, D., Gable, A. L., Nastou, K. C., Lyon, D., Kirsch, R., Pyysalo, S., Doncheva, N. T., Legeay, M., Fang, T., Bork, P., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkaa1074 · Cited by 8,056 · see citing works

The nf-core framework for community-curated bioinformatics pipelines

Ewels, P., Peltzer, A., Fillinger, S., Patel, H., Alneberg, J., Wilm, A., Garcia, M., Tommaso, P. D., & Nahnsen, S. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0439-x · Cited by 4,028 · see citing works

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · see citing works

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

Street, K., Risso, D., Fletcher, R. B., Das, D., Ngai, J., Yosef, N., Purdom, E., & Dudoit, S. (2018) · BMC Genomics · doi:10.1186/s12864-018-4772-0 · Cited by 3,159 · see citing works

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076 · see citing works

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Merad, M., & Martin, J. C. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0331-4 · Cited by 2,472 · see citing works

Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data

Doncheva, N. T., Morris, J. H., Gorodkin, J., & Jensen, L. J. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00702 · Cited by 2,316 · see citing works

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225 · see citing works

The Pathobiology of Vascular Dementia

Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736 · see citing works

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

Montagne, A., Nation, D. A., Sagare, A. P., Barisano, G., Sweeney, M. D., Chakhoyan, A., Pachicano, M., Joe, E., Nelson, A. R., D’Orazio, L. M., et al. (2020) · Nature · doi:10.1038/s41586-020-2247-3 · Cited by 1,281 · see citing works

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

Ulland, T. K., Song, W. M., Huang, S. C.-C., Ulrich, J. D., Sergushichev, A., Beatty, W. L., Loboda, A. A., Zhou, Y., Cairns, N. J., Kambal, A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.023 · Cited by 1,263 · see citing works

An environment-dependent transcriptional network specifies human microglia identity

Gosselin, D., Skola, D., Coufal, N. G., Holtman, I. R., Schlachetzki, J. C. M., Sajti, E., Jaeger, B. N., O’Connor, C., Fitzpatrick, C., Pasillas, M. P., et al. (2017) · Science · doi:10.1126/science.aal3222 · Cited by 1,220 · see citing works

Microglial signatures and their role in health and disease

Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046 · see citing works

MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments

Choi, M., Chang, C.-Y., Clough, T., Broudy, D., Killeen, T., MacLean, B., & Olga Vitek, A. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu305 · Cited by 1,041 · see citing works

Immunomodulatory functions of type I interferons

González-Navajas, J. M., Lee, J., David, M., & Raz, E. (2012) · Nature reviews. Immunology · doi:10.1038/nri3133 · Cited by 1,003 · see citing works

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Bouhaddou, M., Memon, D., Meyer, B., White, K. M., Rezelj, V. V., Marrero, M. C., Polacco, B. J., Melnyk, J. E., Ulferts, S., Kaake, R. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.034 · Cited by 998 · see citing works

NADPH oxidases: An overview from structure to innate immunity-associated pathologies

Panday, A., Sahoo, M. K., Osorio, D., & Batra, S. (2015) · Cellular & Molecular Immunology · doi:10.1038/cmi.2014.89 · Cited by 944 · see citing works

Fibrinogen as a key regulator of inflammation in disease

Davalos, D., & Akassoglou, K. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0290-8 · Cited by 926 · see citing works

Trajectory-based differential expression analysis for single-cell sequencing data

den Berge, K. V., de Bézieux, H. R., Street, K., Saelens, W., Cannoodt, R., Saeys, Y., Dudoit, S., & Clement, L. (2020) · Nature Communications · doi:10.1038/s41467-020-14766-3 · Cited by 796 · see citing works

A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

Absinta, M., Maric, D., Gharagozloo, M., Garton, T., Smith, M. D., Jin, J., Fitzgerald, K. C., Song, A., Liu, P., Lin, J.-P., et al. (2021) · Nature · doi:10.1038/s41586-021-03892-7 · Cited by 768 · see citing works

The spectrum of inflammatory responses

Medzhitov, R. (2021) · Science · doi:10.1126/science.abi5200 · Cited by 718 · see citing works

Complement and coagulation: strangers or partners in crime?

Markiewski, M., Nilsson, B., Ekdahl, K., Mollnes, T., & Lambris, J. D. (2007) · Trends in immunology · doi:10.1016/j.it.2007.02.006 · Cited by 664 · see citing works

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

Hargreaves, D. C., Horng, T., & Medzhitov, R. M. (2009) · Cell · doi:10.1016/j.cell.2009.05.047 · Cited by 649 · see citing works

Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions

Kanchanawong, P., & Calderwood, D. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00531-5 · Cited by 607 · see citing works

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Davalos, D., Kyu Ryu, J., Merlini, M., Baeten, K. M., Le Moan, N., Petersen, M. A., Deerinck, T. J., Smirnoff, D. S., Bedard, C., Hakozaki, H., et al. (2012) · Nature Communications · doi:10.1038/ncomms2230 · Cited by 568 · see citing works

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

Roy, E. R., Wang, B., Wan, Y.-W., Chiu, G., Cole, A., Yin, Z., Propson, N. E., Xu, Y., Jankowsky, J. L., Liu, Z., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133737 · Cited by 563 · see citing works

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

Petersen, M. A., Ryu, J. K., & Akassoglou, K. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.13 · Cited by 527 · see citing works

Molecular control of activation and priming in macrophages

Glass, C. K., & Natoli, G. (2015) · Nature Immunology · doi:10.1038/ni.3306 · Cited by 522 · see citing works

The extracellular matrix and the immune system: A mutually dependent relationship

Sutherland, T. E., Dyer, D. P., & Allen, J. E. (2023) · Science · doi:10.1126/science.abp8964 · Cited by 519 · see citing works

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

Fischer, M. T., Sharma, R., Lim, J. L., Haider, L., Frischer, J. M., Drexhage, J., Mahad, D., Bradl, M., van Horssen, J., & Lassmann, H. (2012) · Brain · doi:10.1093/brain/aws012 · Cited by 507 · see citing works

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity.

Wessels, M. R., Butko, P., Ma, M., Warren, H. B., Lage, A. L., & Carroll, M. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11490 · Cited by 503 · see citing works

Novel mechanisms and functions of complement

Hajishengallis, G., Reis, E. S., Mastellos, D. C., Ricklin, D., & Lambris, J. D. (2017) · Nature Immunology · doi:10.1038/ni.3858 · Cited by 484 · see citing works

Physiological blood–brain transport is impaired with age by a shift in transcytosis

Yang, A. C., Stevens, M. Y., Chen, M. B., Lee, D. P., Stähli, D., Gate, D., Contrepois, K., Chen, W., Iram, T., Zhang, L., et al. (2020) · Nature · doi:10.1038/s41586-020-2453-z · Cited by 477 · see citing works

Leukocyte engagement of fibrin(ogen) via the integrin receptor αMβ2/Mac-1 is critical for host inflammatory response in vivo

Flick, M. J., Du, X., Witte, D. P., Jiroušková, M., Soloviev, D. A., Busuttil, S. J., Plow, E. F., & Degen, J. L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20741 · Cited by 450 · see citing works

Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an Alzheimer's disease model

Merlini, M., Rafalski, V. A., Rios Coronado, P. E., Gill, T. M., Ellisman, M., Muthukumar, G., Subramanian, K. S., Ryu, J. K., Syme, C. A., Davalos, D., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.014 · Cited by 431 · see citing works

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.Preprint

Suh, T. T., Holmbäck, K., Jensen, N. J., Daugherty, C. C., Small, K. M., Simon, D. I., Potter, S., & Degen, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.16.2020 · Cited by 424 · see citing works

Extracellular matrix and matrix receptors in blood–brain barrier formation and stroke

Baeten, K. M., & Akassoglou, K. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20954 · Cited by 397 · see citing works

The biology of TREM receptors

Colonna, M. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00837-1 · Cited by 394 · see citing works

Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection

Ramlall, V., Thangaraj, P., Meydan, C., Foox, J., Butler, D., Kim, J., May, B., Freitas, J. K. D., Glicksberg, B. S., Mason, C. E., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1021-2 · Cited by 350 · see citing works

Immune Signaling in Neurodegeneration

Hammond, T. R., Marsh, S. E., & Stevens, B. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.016 · Cited by 336 · see citing works

The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease

Adams, R. A., Bauer, J., Flick, M. J., Sikorski, S. L., Nuriel, T., Lassmann, H., Degen, J. L., & Akassoglou, K. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061931 · Cited by 335 · see citing works

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

Park, L., Zhou, P., Pitstick, R., Capone, C., Anrather, J., Norris, E. H., Younkin, L., Younkin, S., Carlson, G., McEwen, B. S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711568105 · Cited by 332 · see citing works

Innate Immunity and Neurodegeneration

Labzin, L. I., Heneka, M. T., & Latz, E. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-050715-104343 · Cited by 319 · see citing works

Slingshot: Cell lineage and pseudotime inference for single-cell transcriptomicsPreprint

Street, K., Risso, D., Fletcher, R. B., Das, D., Ngai, J., Yosef, N., Purdom, E. A., & Dudoit, S. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/128843 · Cited by 290 · see citing works

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Ryu, J. K., Petersen, M. A., Murray, S. G., Baeten, K. M., Meyer-Franke, A., Chan, J. P., Vagena, E., Bedard, C., Machado, M. R., Coronado, P. E. R., et al. (2015) · Nature Communications · doi:10.1038/ncomms9164 · Cited by 271 · see citing works

dittoSeq: universal user-friendly single-cell and bulk RNA sequencing visualization toolkit

Bunis, D. G., Andrews, J. M., Fragiadakis, G. K., Burt, T. D., & Sirota, M. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa1011 · Cited by 228 · see citing works

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Ryu, J. K., Rafalski, V. A., Meyer-Franke, A., Adams, R. A., Poda, S. B., Rios Coronado, P. E., Pedersen, L. Ø., Menon, V., Baeten, K. M., Sikorski, S. L., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0232-x · Cited by 213 · see citing works

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Mendiola, A. S., Ryu, J. K., Bardehle, S., Meyer-Franke, A., Ang, K. K.-H., Wilson, C., Baeten, K. M., Hanspers, K., Merlini, M., Thomas, S., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0654-0 · Cited by 199 · see citing works

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

Petersen, M. A., Ryu, J. K., Chang, K.-J., Etxeberría, A., Bardehle, S., Mendiola, A. S., Kamau-Devers, W., Fancy, S. P. J., Thor, A., Bushong, E. A., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.008 · Cited by 198 · see citing works

Fibrin Inhibits Peripheral Nerve Remyelination by Regulating Schwann Cell Differentiation

Akassoglou, K., Yu, W.-M., Akpınar, P., & Strickland, S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00617-7 · Cited by 196 · see citing works

Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier

Silva, L. M., Doyle, A. D., Greenwell‐Wild, T., Dutzan, N., Tran, C. L., Abusleme, L., Juang, L. J., Leung, J., Chun, E. M., Lum, A. G., et al. (2021) · Science · doi:10.1126/science.abl5450 · Cited by 191 · see citing works

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

Dong, Y., D’Mello, C., Pinsky, W., Lozinski, B. M., Kaushik, D. K., Ghorbani, S., Moezzi, D., Brown, D., Melo, F. C., Zandee, S., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00801-z · Cited by 181 · see citing works

Fast, sensitive, and accurate integration of single cell data with HarmonyPreprint

Korsunsky, I., Fan, J., Slowikowski, K., et al. (2018) · bioRxiv · doi:10.1101/461954 · Cited by 177 · see citing works

Novel targets, treatments, and advanced models for intracerebral haemorrhage

Zille, M., Farr, T. D., Keep, R. F., Römer, C., Xi, G., & Boltze, J. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103880 · Cited by 177 · see citing works

Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation

Bekassy, Z., Lopatko Fagerström, I., Bader, M., & Karpman, D. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-021-00634-8 · Cited by 167 · see citing works

Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells

Takizawa, F., Tsuji, S., & Nagasawa, S. (1996) · FEBS Letters · doi:10.1016/s0014-5793(96)01197-0 · Cited by 165 · see citing works

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin αMβ2 binding motif

Flick, M. J., Jeunesse, C. M. L., Talmage, K. E., Witte, D. P., Palumbo, J. S., Pinkerton, M. D., Thornton, S., & Degen, J. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30134 · Cited by 161 · see citing works

Colitis-Associated Cancer Is Dependent on the Interplay between the Hemostatic and Inflammatory Systems and Supported by Integrin αMβ2 Engagement of Fibrinogen

Steinbrecher, K. A., Horowitz, N. A., Blevins, E. A., Barney, K. A., Shaw, M. A., Harmel-Laws, E., Finkelman, F. D., Flick, M. J., Pinkerton, M. D., Talmage, K. E., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3465 · Cited by 158 · see citing works

The phosphoproteome of toll‐like receptor‐activated macrophages

Weintz, G., Olsen, J. V., Frühauf, K., Niedzielska, M., Amit, I., Jantsch, J., Mages, J., Frech, C., Dölken, L., Mann, M., et al. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.29 · Cited by 150 · see citing works

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

Czirr, E., Castello, N. A., Mosher, K. I., Castellano, J. M., Hinkson, I. V., Lucin, K. M., Baeza-Raja, B., Ryu, J. K., Li, L., Farina, S. N., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162011 · Cited by 126 · see citing works

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

Cao, C., Gao, Y., Li, Y., Antalis, T., Castellino, F., & Zhang, L. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40380 · Cited by 121 · see citing works

Visualize omics data on networks with Omics Visualizer, a Cytoscape App

Legeay, M., Doncheva, N. T., Morris, J. H., & Jensen, L. J. (2020) · F1000Research · doi:10.12688/f1000research.22280.1 · Cited by 121 · see citing works

Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer’s disease

Lassmann, H. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0607-8 · Cited by 112 · see citing works

Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease

Venkataraman, A. V., Mansur, A., Rizzo, G., Bishop, C., Lewis, Y., Kocagoncu, E., Lingford-Hughes, A., Huiban, M., Passchier, J., Rowe, J. B., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abk1051 · Cited by 101 · see citing works

Blood will out: vascular contributions to Alzheimer’s disease

Strickland, S. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97509 · Cited by 92 · see citing works

Benchmarking substrate-based kinase activity inference using phosphoproteomic data

Hernández-Armenta, C. I., Ochoa, D., Gonçalves, E., Sáez-Rodríguez, J., & Beltrão, P. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx082 · Cited by 87 · see citing works

Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs

Roopenian, D. C., Low, B. E., Christianson, G. J., Proetzel, G., Sproule, T. J., & Wiles, M. V. (2015) · mAbs · doi:10.1080/19420862.2015.1008345 · Cited by 84 · see citing works

Trajectory-based differential expression analysis for single-cell sequencing dataPreprint

den Berge, K. V., de Bézieux, H. R., Street, K., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/623397 · Cited by 83 · see citing works

Visualize omics data on networks with Omics Visualizer, a Cytoscape App

Legeay, M., Doncheva, N. T., Morris, J. H., et al. (2020) · F1000Research · doi:10.12688/f1000research.22280.2 · Cited by 81 · see citing works

Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis

Magliozzi, R., Hametner, S., Facchiano, F., Marastoni, D., Rossi, S., Castellaro, M., Poli, A., Lattanzi, F., Visconti, A., Nicholas, R. S., et al. (2019) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.50893 · Cited by 74 · see citing works

The Promiscuous Profile of Complement Receptor 3 in Ligand Binding, Immune Modulation, and Pathophysiology

Lamers, C., Plüss, C. J., & Ricklin, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662164 · Cited by 74 · see citing works

Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis

Heurich, M., Föcking, M., Mongan, D., Cagney, G., & Cotter, D. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01197-9 · Cited by 66 · see citing works

Multiple sclerosis is linked to MAPKERK overactivity in microglia

ten Bosch, G. J. A., Bolk, J., Hart, B. A. ‘., & Laman, J. D. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02080-4 · Cited by 63 · see citing works

Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice

Malkov, A., Popova, I., Ivanov, A., Jang, S.-S., Yoon, S. Y., Osypov, A., Huang, Y., Zilberter, Y., & Zilberter, M. (2021) · Communications Biology · doi:10.1038/s42003-021-02551-x · Cited by 59 · see citing works

MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer’s Disease

Chun, Y. S., Kim, M., Lee, S., Kim, M. J., Hong, T.-J., Jeon, J. K., Ganbat, D., Kim, H. T., Kim, S. S., Kam, T., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01713-5 · Cited by 56 · see citing works

Focal Adhesion Kinases in Platelet Function and Thrombosis

Guidetti, G. F., Torti, M., & Canobbio, I. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311787 · Cited by 54 · see citing works

The role of Nup98 in transcription regulation in healthy and diseased cells

Franks, T. M., & Hetzer, M. W. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.10.013 · Cited by 51 · see citing works

Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor

Vidal, B., Ardite, E., Suelves, M., Ruiz‐Bonilla, V., Janué, A., Flick, M. J., Degen, J. L., Serrano, A. L., & Muñoz‐Cánoves, P. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds012 · Cited by 39 · see citing works

Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain

Jaeger, P. A., Lucin, K. M., Britschgi, M., Vardarajan, B. N., Huang, R.-P., Kirby, E. D., Abbey, R. J., Boeve, B. F., Boxer, A. L., Farrer, L. A., et al. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0095-2 · Cited by 34 · see citing works

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

Johnson, J. R., Crosby, D. C., Hultquist, J. F., Kurland, A. P., Adhikary, P., Li, D., Marlett, J. M., Swann, J., Hüttenhain, R., Verschueren, E., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110690 · Cited by 29 · see citing works

BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis

Petersen, M. A., Tognatta, R., Meyer‐Franke, A., Bushong, E. A., Mendiola, A. S., Yan, Z., Muthusamy, A., Merlini, M., Meza-Acevedo, R., Cabriga, B., et al. (2021) · Brain · doi:10.1093/brain/awab106 · Cited by 28 · see citing works

Assembling a corpus of phosphoproteomic annotations using ProtMapper to normalize site information from databases and text miningPreprint

Bachman, J. A., Sorger, P. K., & Gyori, B. M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/822668 · Cited by 22 · see citing works

Paxillin and Hydrogen Peroxide-Inducible Clone 5 Expression and Distribution in Control and Alzheimer Disease Hippocampi

Caltagarone, J., Hamilton, R. L., MURDOCH, G. H., Zheng, J., DeFranco, D. B., & Bowser, R. P. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181d53d98 · Cited by 21 · see citing works

The immunology of blood: connecting the dots at the neurovascular interface

Akassoglou, K. (2020) · Nature Immunology · doi:10.1038/s41590-020-0671-z · Cited by 18 · see citing works

Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma

Chan, J. P., Merlini, M., Gao, H.-X., Mendiola, A. S., Akassoglou, K., Rubenstein, J. L., & Ryu, J. K. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.12.010 · Cited by 12 · see citing works

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodelingPreprint

Johnson, J. R., Crosby, D. C., Hultquist, J. F., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.06.896365 · Cited by 4 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01104-7 · Cited by 638 · see citing works

Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases

Chen, T., Dai, Y., Hu, C., Lin, Z., Wang, S., Yang, J., Zeng, L., Li, S., & Li, W. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00557-1 · Cited by 201 · see citing works

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease

Shi, S. M., Suh, R. J., Shon, D. J., García, F., Buff, J. K., Atkins, M., Li, L., Lu, N., Sun, B., Luo, J., et al. (2025) · Nature · doi:10.1038/s41586-025-08589-9 · Cited by 160 · see citing works

Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression

Laurindo, L. F., Dias, J. A., Araújo, A. C., Pomini, K. T., Galhardi, C. M., Detregiachi, C. R. P., Haber, L. S. D. A., Roque, D. D., Bechara, M. D., de Castro, M. V. M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1305933 · Cited by 149 · see citing works

Microglia at the blood brain barrier in health and disease

Mayer, M. G., & Fischer, T. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1360195 · Cited by 128 · see citing works

Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology

Kukanja, P., Langseth, C. M., Rubio Rodríguez-Kirby, L. A., Agirre, E., Zheng, C., Raman, A., Yokota, C., Avenel, C., Tiklová, K., Guerreiro-Cacais, A. O., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.030 · Cited by 124 · see citing works

Neurodegeneration and demyelination in multiple sclerosis

Garton, T. P., Gadani, S. P., Gill, A. J., & Calabresi, P. A. (2024) · Neuron · doi:10.1016/j.neuron.2024.05.025 · Cited by 122 · see citing works

Fibrin drives thromboinflammation and neuropathology in COVID-19

Ryu, J. K., Yan, Z., Montano, M., Sozmen, E. G., Dixit, K., Suryawanshi, R. K., Matsui, Y., Helmy, E., Kaushal, P., Makanani, S. K., et al. (2024) · Nature · doi:10.1038/s41586-024-07873-4 · Cited by 116 · see citing works

mTOR-Mediated Immunometabolic Reprogramming Nanomodulators Enable Sensitive Switching of Energy Deprivation-Induced Microglial Polarization for Alzheimer’s Disease Management

Yang, F., Zhao, D., Cheng, M., Liu, Y., Chen, Z., Chang, J. K., & Dou, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c03232 · Cited by 64 · see citing works

Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation

Dean, T., Mendiola, A. S., Yan, Z., Meza-Acevedo, R., Cabriga, B., Akassoglou, K., & Ryu, J. K. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03092-w · Cited by 53 · see citing works

Revolutionizing Blood Collection: Innovations, Applications, and the Potential of Microsampling Technologies for Monitoring Metabolites and Lipids

Bossi, E., Limo, E., Pagani, L., Monza, N., Serrao, S., Denti, V., Astarita, G., & Paglia, G. (2024) · Metabolites · doi:10.3390/metabo14010046 · Cited by 52 · see citing works

Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis

Wang, P., Jiang, F., Zeng, Q., Yin, W., Hu, Y.-Z., Li, Q., & Hu, Z. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03016-8 · Cited by 50 · see citing works

Kupffer cell programming by maternal obesity triggers fatty liver disease

Huang, H., Balzer, N. R., Seep, L., Šplíchalová, I., Blank-Stein, N., Viola, M. F., Taveras, E. F., Acil, K., Fink, D., Petrovic, F., et al. (2025) · Nature · doi:10.1038/s41586-025-09190-w · Cited by 50 · see citing works

Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model

Rao, A. T., Chen, N., Kim, M. J., Blumenfeld, J. R., Yip, O., Liang, Z., Shostak, D. M., Hao, Y., Nelson, M. R., Koutsodendris, N., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.10.005 · Cited by 46 · see citing works

Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke

Bourne, J. H., Suthya, A. R., Wanrooy, B. J., Wilson, J. L., Wen, S., Bastow, C. R., Zheng, G., Rank, M. M., Hickey, M. J., & Wong, C. H. Y. (2025) · Communications Biology · doi:10.1038/s42003-025-08636-1 · Cited by 45 · see citing works

Detrimental Effects of ApoE ε4 on Blood–Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer’s Disease

Kirchner, K., Garvert, L., Kühn, A. L., Bonk, S., Grabe, H. J., & der Auwera, S. V. (2023) · Cells · doi:10.3390/cells12212512 · Cited by 39 · see citing works

Macrophage fate: to kill or not to kill?

Marrufo, A. M., & Flores‐Mireles, A. L. (2024) · Infection and Immunity · doi:10.1128/iai.00476-23 · Cited by 32 · see citing works

Engineered Wnt7a ligands rescue blood–brain barrier and cognitive deficits in a COVID-19 mouse model

Trevino, T. N., Fogel, A., Otkiran, G., Niladhuri, S. B., Sanborn, M. A., Class, J., Almousawi, A. A., Vanhollebeke, B., Tai, L. M., Rehman, J., et al. (2024) · Brain · doi:10.1093/brain/awae031 · Cited by 30 · see citing works

Pioneering discovery and therapeutics at the brain-vascular-immune interface

Akassoglou, K., Davalos, D., Mendiola, A. S., Petersen, M. A., Ryu, J. K., Schachtrup, K., & Yan, Z. (2024) · Cell · doi:10.1016/j.cell.2024.09.018 · Cited by 27 · see citing works

Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction

Hansen, C. E., Vacondio, D., van der Molen, L., Jüttner, A. A., Fung, W. K., Karsten, M., van het Hof, B., Fontijn, R. D., Kooij, G., Witte, M. E., et al. (2025) · Cell Death & Disease · doi:10.1038/s41419-024-07306-0 · Cited by 27 · see citing works

Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models

Miller, S. R., Luxem, K., Lauderdale, K., Nambiar, P., Honma, P. S., Ly, K. K., Bangera, S., Bullock, M., Shin, J., Kaliss, N., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114870 · Cited by 24 · see citing works

Fibrin-targeting immunotherapy for dementia

Kantor, A. B., Akassoglou, K., & Stavenhagen, J. B. (2023) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2023.105 · Cited by 24 · see citing works

Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases

Wißfeld, J., Assale, T. A., Cuevas-Ríos, G., Liao, H., & Neumann, H. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1330874 · Cited by 23 · see citing works

Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer’s disease

Islam, R., Choudhary, H. H., Zhang, F., Mehta, H., Yoshida, J., Thomas, A. J., & Hanafy, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-96456-y · Cited by 22 · see citing works

Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects

Ashok, C., Kimble, A. L., Burrage, E. N., Helming, S. B., Tyburski, J. D., Leclair, N. K., Omar, O. M., Zuberi, A. R., Murphy, M., Jellison, E. R., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads0505 · Cited by 21 · see citing works

Erjingpill bionic cerebrospinal fluid alleviates LPS-induced inflammatory response in BV2 cells by inhibiting glycolysis via mTOR

Wang, S., Wu, L., Xie, Y., Ge, S., Wu, Y., Chen, L., Yi, L., Yang, J., Duan, F., & Huang, L. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118412 · Cited by 20 · see citing works

Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization

Boutou, A., Roufagalas, I., Politopoulou, K., Tastsoglou, S., Abouzeid, M., Skoufos, G., de Juan, L. V., Ko, J. H., Kyrargyri, V., Hatzigeorgiou, A. G., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114894 · Cited by 20 · see citing works

Using focused ultrasound to modulate microglial structure and function

Grewal, S., de Andrade, E. G., Kofoed, R. H., Matthews, P. M., Aubert, I., Tremblay, M.-È., & Morse, S. V. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1290628 · Cited by 24 · see citing works

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

Caro, I., Western, D., Namba, S., Sun, N., Kawaguchi, S., He, Y., Fujita, M., Roshchupkin, G. V., D’Aoust, T., Duperron, M., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-01006-w · Cited by 17 · see citing works

Myeloid lineage C3 induces reactive gliosis and neuronal stress during CNS inflammation

Garton, T. P., Smith, M. D., Kesharwani, A., Gharagozloo, M., Oh, S., Na, C. H., Absinta, M., Reich, D. S., Zack, D. J., & Calabresi, P. A. (2025) · Nature Communications · doi:10.1038/s41467-025-58708-3 · Cited by 18 · see citing works

Neuroinflammation: An Oligodendrocentric View

Festa, L. K., Jordan‐Sciutto, K. L., & Grinspan, J. B. (2025) · Glia · doi:10.1002/glia.70007 · Cited by 16 · see citing works

Electroacupuncture relieves chronic pain by promoting microglia M2 polarization in lumbar disc herniation rats

Yang, J.-X., Zhu, J., Ni, K., Yang, H., Zhang, H., & Ma, Z. (2023) · Neuroreport · doi:10.1097/wnr.0000000000001935 · Cited by 13 · see citing works

Rebuilding insight into the pathophysiology of Alzheimer's disease through new blood-brain barrier models

Matsuo, K., & Nishihara, H. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390978 · Cited by 13 · see citing works

Local Production of Acute Phase Proteins: A Defense Reaction of Cancer Cells to Injury with Focus on Fibrinogen

Hamar, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063435 · Cited by 13 · see citing works

Mononuclear phagocytes in autoimmune neuroinflammation

Gogoleva, V. S., Mundt, S., Feo, D. D., & Becher, B. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.08.005 · Cited by 13 · see citing works

Multiple Sclerosis: Glial Cell Diversity in Time and Space

Kooistra, S. M., & Schirmer, L. (2024) · Glia · doi:10.1002/glia.24655 · Cited by 13 · see citing works

Molecular Basis of Neuronal and Microglial States in the Aging Brain and Impact on Cerebral Blood Vessels

Maeda, C., & Tsuruta, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084443 · Cited by 13 · see citing works

Loss of Endothelial TDP-43 Leads to Blood Brain Barrier Defects in Mouse Models of Amyotrophic Lateral Sclerosis and Frontotemporal DementiaPreprint

Ashok, C., Kimble, A. L., Tyburski, J. D., Leclair, N. K., Zuberi, A. R., Murphy, M., Jellison, E. R., Reese, B., Hu, X., Lutz, C. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.13.571184 · Cited by 13 · see citing works

APOE- ε4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer’s diseasePreprint

Bhattarai, P., Yılmaz, E., Cakir, E. Ö., Yüceer, H., Lee, A., Ma, Y., Çelikkaya, H., Coşacak, M. İ., Haage, V. C., Wang, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.24.634732 · Cited by 12 · see citing works

Acute neuroinflammation induces prolonged transcriptional reprogramming in microglia

Moon, S., Kim, C. G., Kim, Y.-K., Yun, C., Shin, M., & Seo, H. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03572-7 · Cited by 11 · see citing works

Microglia and Myeloid Cell Populations of the Developing Mouse Retina

Martineau, S., Valdez‐Lopez, J. C., Zarnick, S., & Kay, J. N. (2025) · Glia · doi:10.1002/glia.70115 · Cited by 11 · see citing works

Cerebral biomimetic nano-drug delivery systems: A frontier strategy for immunotherapy

Tian, H., Yao, J., Ba, Q., Meng, Y., Cui, Y., Quan, L., Gong, W., Wang, Y., Yang, Y., Yang, M., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.058 · Cited by 11 · see citing works

Neoplastic ICAM-1 protects lung carcinoma from apoptosis through ligation of fibrinogen

Wang, S., Wang, J., Liu, C., Yang, L., Tan, X., Chen, S., Xue, Y., Ji, H., Ge, G., & Chen, J. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06989-9 · Cited by 10 · see citing works

Ageing-related changes in the regulation of microglia and their interaction with neurons

Rommy von Bernhardi, M., & Eugenín, J. L. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110241 · Cited by 10 · see citing works

Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after blood–brain barrier disruption

Weaver, O., Gano, D. L., Zhou, Y., Kim, H., Tognatta, R., Yan, Z., Ryu, J. K., Brandt, C., Basu, T., Grana, M., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2323050121 · Cited by 9 · see citing works

Traumatic Brain Injury and Alzheimer’s Disease: A Shared Neurovascular Hypothesis

Cognacq, G., Attwood, J. E., & DeLuca, G. C. (2025) · Neuroscience Insights · doi:10.1177/26331055251323292 · Cited by 9 · see citing works

Comprehensive immune ageing reveals TREM2/TIM3 myeloid cells drive brain immune evasion

Segura‐Collar, B., Mondéjar-Ruescas, L., Alcivar-López, D., Garranzo‐Asensio, M., Mata-Martínez, P., García‐Escudero, R., Hernández‐Laín, A., Sepúlveda-Sánchez, J. M., Pérez‐Núñez, Á., Ávila, J., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105833 · Cited by 9 · see citing works

Fibrinogen drives neuroinflammation and neuropathology in perioperative neurocognitive disorders

Wang, X., Jiang, S., Di, L., Li, S., Chen, H., Huang, P., Cao, T., Jin, W., & Huang, L. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115906 · Cited by 9 · see citing works

Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium

Payne, T., Taylor, J., Kunkel, D., Konieczka, K., Ingram, F., Blennow, K., Zetterberg, H., Pearce, R. A., Meyer‐Franke, A., Terrando, N., et al. (2024) · BJA Open · doi:10.1016/j.bjao.2024.100349 · Cited by 8 · see citing works

Neutrophils linking periodontitis and Alzheimer's disease

Li, J., Liu, L., Xu, C., Zhang, J., & Wang, F. (2025) · Oral Science and Homeostatic Medicine · doi:10.26599/oshm.2025.9610022 · Cited by 8 · see citing works

Influenza A virus infection during pregnancy increases transfer of maternal bloodborne molecules to fetal tissues

Gonzalez-Ricon, R., Otero, A. M., Chalen, I., Savas, J. N., Adetunji, S. A., & Antonson, A. M. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106069 · Cited by 8 · see citing works

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Wu, Q., Cong, P., Li, Z., Zhang, Y., Wu, H., Zhang, Q., Li, Y., Li, T., Miao, Q., Zheng, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202502034 · Cited by 8 · see citing works

A Novel Mouse Model for Cerebral Inflammatory Demyelination in X‐Linked Adrenoleukodystrophy: Insights into Pathogenesis and Potential Therapeutic Targets

Hashemi, E., Srivastava, I. N., Aguirre, A., Yoseph, E., Kaushal, E., Awani, A., Ryu, J. K., Akassoglou, K., Talebian, S., Chu, P., et al. (2024) · Annals of Neurology · doi:10.1002/ana.27117 · Cited by 8 · see citing works

Macrophage Lyn Kinase Is a Sex‐Specific Regulator of Post–Subarachnoid Hemorrhage Neuroinflammation

Islam, R., Choudhary, H. H., Zhang, F., Mehta, H., Yoshida, J., Thomas, A. J., & Hanafy, K. A. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039409 · Cited by 7 · see citing works

Targeting hypercoagulability in ischemic stroke modulates fibrin-driven microglial polarization via JAK-STAT pathway

Guan, S., Lu, T., Li, L., Zhang, Y., Huang, C., Li, C., Li, B., Hu, J., & Wan, C. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03582-5 · Cited by 7 · see citing works

Role of glycolysis-mediated histone lactylation in microglial activation and progression of neurodegenerative diseases

Wang, S., Wang, J., Hu, Z., Wu, L., & Huang, L. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115663 · Cited by 7 · see citing works

The State of Alzheimer's Research and the Path Forward

Fillit, H. M., Vellas, B. J., & Hara, Y. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.102 · Cited by 7 · see citing works

The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation

Ehirchiou, D., Bernabei, I., Pandian, V. D., Nasi, S., Chobaz, V., Castelblanco, M., So, A. K. L., Martinon, F., Li, X., Acha‐Orbea, H., et al. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-024-03350-5 · Cited by 7 · see citing works

First-in-human Evaluation of Safety and Dosimetry of [64Cu]FBP8: A fibrin-binding PET Probe

Izquierdo‐Garcia, D., Désogère, P. A., Philip, A. L., Sosnovik, D. E., Catana, C., & Caravan, P. D. (2024) · Molecular Imaging and Biology · doi:10.1007/s11307-024-01973-3 · Cited by 6 · see citing works

Lactobacillus johnsonii HL79 modulates the microbiota-gut-brain axis to protect cognitive function in mice chronically exposed to high altitude

Zhao, Z., Zhang, X., Sun, N., Duan, L., Xin, J., Li, H., Ni, X., Wang, H., Ma, H., & Bai, Y. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1561400 · Cited by 6 · see citing works

Comparisons in microglial responses to ischemic–hypoxic brain injury in neonatal and adult mice analyzed by transcriptome integration and deconvolution technologies

Liu, Y., Chen, M., Zhang, L., Lyu, T., Geng, Y., Li, W., Shi, Y., Wang, M., Kele, J., & Li, Z. (2025) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-25-00004 · Cited by 6 · see citing works

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human

Brioschi, S., Belk, J. A., Storck, S. E., Wu, Y., Wang, Z., Feng, Z., van Olst, L., Emery, J. L., Sudan, R., Wu, J., et al. (2026) · Cell · doi:10.1016/j.cell.2026.07.043 · Cited by 6 · see citing works

Astrogliosis in the GFAP-CreERT2:Rosa26iDTR Mouse Model Does Not Exacerbate Retinal Microglia Activation or Müller Cell Gliosis under Hypoxic Conditions

Rorex, C., Cardona, S. M., Church, K. A., Rodriguez, D., Vanegas, D., Saldivar, R. A., Faz, B. N., & Cardona, A. E. (2024) · Biomolecules · doi:10.3390/biom14050567 · Cited by 6 · see citing works

Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis

Misicka, E., Huang, Y., Loomis, S. J., Sadhu, N., Fisher, E., Gafson, A., Runz, H., Tsai, E. A., Jia, X., Herman, A. H., et al. (2024) · Neurology Genetics · doi:10.1212/nxg.0000000000200159 · Cited by 6 · see citing works

Alzheimer's disease and vascular biology – A focus on the procoagulant state

Casquero‐Veiga, M., Cerón, C., & Cortés‐Canteli, M. (2025) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2025.102528 · Cited by 6 · see citing works

From Organotypic Mouse Brain Slices to Human Alzheimer Plasma Biomarkers: A Focus on Microglia

Steiner, K., Yılmaz, N., Gern, A., Marksteiner, J., Faserl, K., Villunger, M., Sarg, B., & Humpel, C. (2024) · Biomolecules · doi:10.3390/biom14091109 · Cited by 6 · see citing works

Fibrinogen regulates microglial function through the JAK2/STAT3 signaling pathway

Li, X., Song, X., Yi, F., & Hou, H. (2025) · Cellular Immunology · doi:10.1016/j.cellimm.2025.104976 · Cited by 5 · see citing works

Development of a humanized anti-fibrin monoclonal antibody for the treatment of neuroinflammatory and retinal diseases

Kantor, A. B., Rickert, M., Cheng, H., Flanagan, K., Salgotra, V., Suppahia, A., Ryu, J. K., Widboom, P., Warfield, J. R., Akassoglou, K., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03650-w · Cited by 5 · see citing works

The interplay between neuroinflammation and endothelial dysfunction in cerebral small vessel disease

Jin, C., & Zhao, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1809556 · Cited by 5 · see citing works

High transparent antifouling material for endoscope lens by lubricant‑infused nano re-entrant structure

Zhao, Y., Liu, Y., Shi, W., Liu, H., Liu, J., Zhao, L., Shi, H., Li, S., Chang, C., Wu, S., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.158262 · Cited by 4 · see citing works

Cooperative multi-view integration with Scalable and Interpretable Model Explainer

Choi, J. J., Kalafut, N. C., Gruenloh, T., Engelman, C., Lu, T.-Y., & Wang, D.-F. (2025) · bioRxiv · doi:10.1038/s42256-025-01111-w · Cited by 2 · see citing works

Differential Responses of Human iPSC-Derived Microglia to Stimulation with Diverse Inflammogens

Wolfbeisz, C., Suess, J., Dreser, N., Leisner, H., Brüll, M., Fandrich, M., Schneiderhan‐Marra, N., Poetz, O., Härtung, T., & Leist, M. (2025) · Cells · doi:10.3390/cells14211687 · Cited by 4 · see citing works

Metabolic and epigenetic dysregulation in IDH1/2-mutant gliomas: A microglial-mediated mechanism of blood-brain barrier disruption

Pan, X.-H., Lan, B., Wang, N., Su, J., & Gao, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115970 · Cited by 3 · see citing works

Oxidative-Stress-Associated Molecular Signatures in Immune-Mediated Diseases: A Systematic Review Integrating Machine Learning and Systems Biology Approaches

Mittal, R., Valerio, E. A., Mutha, V., Raj, A., & Hirani, K. (2026) · Antioxidants · doi:10.3390/antiox15050548 · Cited by 3 · see citing works

Mesenchymal stromal cells suppress microglial activation and tumor necrosis factor production

Xu, L., Min, H., Saha, A., Gunaratne, A., Schwartzman, J. D., Parrott, R. E., Kurtzberg, J., & Filiano, A. J. (2023) · Cytotherapy · doi:10.1016/j.jcyt.2023.11.006 · Cited by 3 · see citing works

Activators of neurotoxic microglia in neurodegeneration: is the answer in blood?

Finney, C. A., Wilkins, H., Swerdlow, R. H., & Brown, D. A. (2023) · Immunology and Cell Biology · doi:10.1111/imcb.12674 · Cited by 3 · see citing works

Metabolic syndrome in New Zealand Obese mice promotes microglial-vascular interactions and reduces microglial plasticityPreprint

MacLean, M., Marola, O. J., Cossette, T. L., Diemler, C. A., Hewes, A. A., Keezer, K. J., Onos, K. D., & Howell, G. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.04.560877 · Cited by 3 · see citing works

A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brainPreprint

Radabaugh, H. L., Keller, J. N., Radtke, C. H., Kunney, C., Karvelas, N., Chan, H. W., Brathaban, N., Meyer‐Franke, A., Casaletto, K. B., Zetterberg, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.27.684881 · Cited by 3 · see citing works

Preoperative prediction model for benign and malignant gallbladder polyps on the basis of machine-learning algorithms

Zeng, J., Hu, W., Wang, Y., Jiang, Y., Peng, J., Li, J., Liu, X., Zhang, X., Tan, B., Zhao, D., et al. (2025) · Surgery · doi:10.1016/j.surg.2025.109427 · Cited by 2 · see citing works

Local microglial activation induced and labeled in the retina in a novel subretinal hemorrhage mouse model

Balogh, B., Zille, M., Szarka, G., Péntek, L., Futácsi, A., Völgyi, B., & Kovács‐Öller, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-09007-w · Cited by 2 · see citing works

Platelet-Derived Granules and Extracellular Vesicles in Neurodegenerative Diseases: Neurovascular Mechanisms and Clinical Implications

Lee, B. M., Yoo, J.-R., & Jung, Y. (2026) · Cells · doi:10.3390/cells15080692 · Cited by 2 · see citing works

BDNF/TrkB Signaling in the Brain–Kidney Axis Under Functional Stress

Beknazarova, A., Kuvaeva, V., Baltin, M. E., Mutig, K., & Bobylev, A. G. (2026) · Biology · doi:10.3390/biology15090696 · Cited by 2 · see citing works

Endothelial ferroptosis in blood–brain barrier dysfunction and neuroinflammation: mechanisms and immune–vascular crosstalk

Liu, Y., Yin, L., Zhang, P., & Li, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1825000 · Cited by 2 · see citing works

Neuroinflammation in Alzheimer’s and Parkinson’s diseases: pathogenic mechanisms and therapeutic strategies

Wang, Q.-Q., Sun, Q.-Q., Guo, Y.-S., Yin, S., & Zhou, J. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00571-3 · Cited by 2 · see citing works

The Neuroimmunological Nexus of Multiple Sclerosis: Deciphering the Microglial Transcriptomic Tapestry

Jha, A., & Kumar, H. (2024) · Neuroglia · doi:10.3390/neuroglia5030017 · Cited by 3 · see citing works

Mac-1 regulates disease stage–specific immunosuppression via the nitric oxide pathway in autoimmune disease

Wang, W., Cao, C., Pandian, V. D., Ye, H., Chen, H., & Zhang, L. (2025) · Science Advances · doi:10.1126/sciadv.ads3728 · Cited by 2 · see citing works

Genetic architecture of Alzheimer’s disease is enriched in peripheral immune and metabolic programsPreprint

Cunha, C., Avelli, M. P., Romero-Lado, M. J., Martínez, R., Belanich, J. R., Jones, T. R., Claussnitzer, M., Loos, R. J. F., & Kilpeläinen, T. O. (2026) · medRxiv · doi:10.64898/2026.02.09.26344392 · Cited by 2 · see citing works

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome and decision-making by blocking fibrin in a model of Alzheimer’s diseasePreprint

Yan, Z., Mendiola, A. S., Lauderdale, K., Kim, K.-Y., Yong, Y., Leng, K., Bushong, E. A., Schuck, R., Meyer‐Franke, A., Agrawal, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.01.722077 · Cited by 2 · see citing works

CORN 2.0 - Condition Orientated Regulatory Networks 2.0

Leung, R. W. T., Zhang, X., Chen, Z., Liang, Y., Huang, S., Yang, Z., Zong, X., Jiang, X., Lin, R., Deng, W., et al. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.04.003 · Cited by 1 · see citing works

Immunotherapies in progressive multiple sclerosis

Neziraj, T., Kappos, L., & Pröbstel, A. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-323-90887-0.00021-3 · Cited by 1 · see citing works

Spatial Changes in Hippocampal Transcriptomic Profiles Following Limbic Non-convulsive Status Epilepticus: Insights into Long-Term Inflammation and Cognitive Deficits

Elbaset, M. A., Jammal, R. E., Khan, N., Yeh, I., Looney, A., Nguyen, T., Al-Juboori, M., Flath-Everhard, G. T., Conrad, S., Abramovici, S., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05698-y · Cited by 1 · see citing works

Association between low handgrip strength and the increased risk of age-related macular degeneration: results from UK biobank cohort study

Wang, S., Yu, H., Qu, Y., Zheng, K., Luo, H., Chen, R., Jia, H., Liu, X., & Sun, X. (2025) · Aging Clinical and Experimental Research · doi:10.1007/s40520-025-03208-z · Cited by 1 · see citing works

Exploring the Expression Changes of Immune Genes in Alzheimer's Disease: A Study on ANXA1, VCAM1, and CCL2

Fattahi, F., Abed, S., Kouchakali, G., Derakhshan, S. M., Sadeh, R. N., & Khaniani, M. S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05821-z · Cited by 1 · see citing works

Immunosenescence as a driver of the transition from frailty to multimorbidity

Qiu, R., Zhang, D., & Feng, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1810241 · Cited by 1 · see citing works

Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting

Lee, H., Rone, J. M., Lee, J.-H., & Quintana, F. J. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01313-2 · Cited by 2 · see citing works

Red blood cell-derived parameters as a potential tool in the differential diagnosis of parkinsonian syndromes

Madetko‐Alster, N., Otto‐Ślusarczyk, D., Migda, B., Chunowski, P., Struga, M., & Alster, P. (2026) · Scientific Reports · doi:10.1038/s41598-026-62325-5 · Cited by 1 · see citing works

Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease

Bhattarai, P., Yılmaz, E., Cakir, E. Ö., Tayran, H., Haq, I., Murphy, D., Keller, J. N., Grand, Q. L., Eschbach, J., Çelikkaya, H., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01204-0 · Cited by 1 · see citing works

Knockdown of BCL-3 Attenuates Inflammatory Response in Intracerebral Hemorrhage Through an rBMECs/MGs Microenvironment

Ma, J., Yin, H., Ran, Z., Luo, T., Jin, Z., Zheng, L., & Zhang, F. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.11.025 · Cited by 1 · see citing works

Administration of Noggin Suppresses Fibrinogen Leakage into the Brain in the Acute Phase After Traumatic Brain Injury in Mice

Yasunaga, M., Takata, F., Iwao, T., Mizoguchi, J., Tajima, N., & Dohgu, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073002 · Cited by 1 · see citing works

Fibrin induces neurotoxic microglia gene programs in neurodegeneration

(2023) · Nature Immunology · doi:10.1038/s41590-023-01542-w · Cited by 5 · see citing works

Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity

Piers, T. M., East, E., Villegas-Llerena, C., Sevastou, I. G., Matarín, M., Hardy, J., & Pocock, J. M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00404 · Cited by 20 · see citing works

Unlocking Blood Drivers of Neurodegeneration: Mechanisms and therapies

Akassoglou, K. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.083655 · Cited by 1 · see citing works

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Davalos, D., Kyu Ryu, J., Merlini, M., Baeten, K. M., Le Moan, N., Petersen, M. A., Deerinck, T. J., Smirnoff, D. S., Bedard, C., Hakozaki, H., et al. (2012) · Nature Communications · doi:10.1038/ncomms2230 · Cited by 568 · see citing works

Fibrin and fibrinogen pathways in microglia fibrinogen-induced signalling – implications for neurodegeneration

Piers, T. M. (2012) · UCL Discovery (University College London) · Cited by 1 · see citing works