Acosta, Juan Carlos

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,278

Chemokine signaling via the CXCR2 receptor reinforces senescence

Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,801

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 788

Senescence impairs successful reprogramming to pluripotent stem cells

Banito, A., Rashid, S. T., Acosta, J. C., Li, S., Pereira, C. F., Geti, I., Pinho, S., Silva, J. C., Azuara, V., Walsh, M., et al. (2009) · Genes & Development

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 642

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

Barradas, M., Anderton, E., Acosta, J. C., Li, S., Banito, A., Rodriguez-Niedenführ, M., Maertens, G., Banck, M., Zhou, M.-M., Walsh, M. J., et al. (2009) · Genes & Development

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 352

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

Ferreira-Gonzalez, S., Lu, W.-Y., Raven, A., Dwyer, B., Man, T. Y., O’Duibhir, E., Lewis, P. J. S., Campana, L., Kendall, T. J., Bird, T. G., et al. (2018) · Nature Communications

Liver Diseases and ImmunityLiver physiology and pathology

Cited by 161

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

Hari, P., Millar, F. R., Tarrats, N., Birch, J., Quintanilla, A., Rink, C. J., Fernández-Duran, I., Muir, M., Finch, A. J., Brunton, V. G., et al. (2019) · Science Advances

Telomeres, Telomerase, and SenescenceImmune Response and Inflammation

Cited by 154

Notch Signaling Mediates Secondary Senescence

Teo, Y. V., Rattanavirotkul, N., Olova, N., Salzano, A., Quintanilla, A., Tarrats, N., Kiourtis, C., Müller, M., Green, A. R., Adams, P. D., et al. (2019) · Cell Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 149

Discovery of senolytics using machine learning

Smer-Barreto, V., Quintanilla, A., Elliott, R. J. R., Dawson, J. C., Sun, J., Campa, V. M., Lorente-Macías, Á., Unciti-Broceta, A., Carragher, N. O., Acosta, J. C., et al. (2023) · Nature Communications

Computational Drug Discovery MethodsTelomeres, Telomerase, and Senescence

Cited by 139

Control of senescence by CXCR2 and its ligands

Acosta, J. C., Loghlen, A., Banito, A., Raguz, S., & Gil, J. (2008) · Cell Cycle

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 106

Nuclear pore density controls heterochromatin reorganization during senescence

Boumendil, C., Hari, P., Olsen, K. C. F., Acosta, J. C., & Bickmore, W. A. (2019) · Genes & Development

Nuclear Structure and FunctionTelomeres, Telomerase, and Senescence

Cited by 89

MYC in chronic myeloid leukemia: induction of aberrant DNA synthesis and association with poor response to imatinib

Albajar, M., Gómez-Casares, M. T., Llorca, J., Mauleon, I., Vaqué, J. P., Acosta, J. C., Bermúdez, A., Donato, N., Delgado, M. D., & León, J. (2011) · Molecular Cancer Research

Chronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia Research

Cited by 62

Reversal of Mitochondrial Malate Dehydrogenase 2 Enables Anaplerosis via Redox Rescue in Respiration-Deficient Cells

Altea-Manzano, P., Vandekeere, A., Edwards-Hicks, J., Roldan, M., Abraham, E., Lleshi, X., Guerrieri, A. N., Berardi, D., Wills, J., Junior, J. M., et al. (2022) · Molecular Cell

Mitochondrial Function and PathologyCancer, Hypoxia, and Metabolism

Cited by 57

Selective cargo and membrane recognition by SNX17 regulates its interaction with Retriever

Martín-González, A., Méndez-Guzmán, I., Zabala-Zearreta, M., Quintanilla, A., García-López, A., Martínez-Lombardía, E., Albesa-Jové, D., Acosta, J. C., & Lucas, M. (2025) · EMBO Reports

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 15