Varelas, Xaralabos

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinković, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Hippo pathway signaling and YAP/TAZInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 874

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

Dey, A., Varelas, X., & Guan, K.-L. (2020) · Nature Reviews Drug Discovery

Hippo pathway signaling and YAP/TAZTGF-β signaling in diseases

Cited by 860

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

Varelas, X. (2014) · Development

Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics

Cited by 665

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

Lagares, D., Santos, A., Grasberger, P. E., Liu, F., Probst, C. K., Rahimi, R. A., Sakai, N., Kuehl, T., Ryan, J., Bhola, P., et al. (2017) · Science Translational Medicine

Systemic Sclerosis and Related DiseasesCell death mechanisms and regulation

Cited by 246

The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7

Chaulk, S. G., Lattanzi, V. J., Hiemer, S. E., Fahlman, R. P., & Varelas, X. (2014) · Journal of Biological Chemistry

Hippo pathway signaling and YAP/TAZMicroRNA in disease regulation

Cited by 101

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression

Jones, D. L., Haak, A. J., Caporarello, N., Choi, K. M., Ye, Z., Yan, H., Varelas, X., Ordog, T., Ligresti, G., & Tschumperlin, D. J. (2019) · Journal of Cell Science

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisHistone Deacetylase Inhibitors Research

Cited by 77

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Haak, A., Kostallari, E., Sicard, D., Ligresti, G., Choi, K. M., Caporarello, N., Jones, D., Tan, Q., Meridew, J., Diaz Espinosa, A., et al. (2019) · Mechanisms of lung injury and repair

Hippo pathway signaling and YAP/TAZInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 11