Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

Wound repair and regeneration

Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542 · see citing works

Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works

The BCL-2 protein family: opposing activities that mediate cell death

Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,704 · see citing works

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541 · see citing works

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Oltersdorf, T., Elmore, S. W., Shoemaker, A. R., Armstrong, R. C., Augeri, D. J., Belli, B., Bruncko, M., Deckwerth, T. L., Dinges, J., Hajduk, P. J., et al. (2005) · Nature · doi:10.1038/nature03579 · Cited by 3,407 · see citing works

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Czabotar, P. E., Lessene, G., Strasser, A., & Adams, J. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3722 · Cited by 3,219 · see citing works

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Souers, A. J., Leverson, J. D., Boghaert, E. R., Ackler, S. L., Catron, N. D., Chen, J., Dayton, B. D., Ding, H., Enschede, S. H., Fairbrother, W. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3048 · Cited by 3,058 · see citing works

The Myofibroblast

Hinz, B., Phan, S. H., Thannickal, V. J., Galli, A., Bochaton-Piallat, M.-L., & Gabbiani, G. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070112 · Cited by 2,068 · see citing works

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

Tse, C., Shoemaker, A. R., Adickes, J., Anderson, M. G., Chen, J., Jin, S., Johnson, E. F., Marsh, K. C., Mitten, M. J., Nimmer, P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5836 · Cited by 1,992 · see citing works

Fibrosis–a common pathway to organ injury and failure

Rockey, D. C., Bell, P. D., & Hill, J. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1300575 · Cited by 1,428 · see citing works

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

Certo, M. V., Moore, V. D. G., Nishino, M., Wei, G., Korsmeyer, S. J., Armstrong, S. A., & Letai, A. G. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.027 · Cited by 1,290 · see citing works

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

Desmoulière, A., Redard, M., Darby, I. A., & Gabbiani, G. (1995) · Europe PMC (PubMed Central) · Cited by 1,173 · see citing works

Systemic sclerosis: a prototypic multisystem fibrotic disorder

Varga, J., & Abraham, D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31139 · Cited by 1,164 · see citing works

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

Jiang, H., Hegde, S., Knolhoff, B. L., Zhu, Y., Herndon, J. M., Meyer, M. A., Nywening, T. M., Hawkins, W. G., Shapiro, I. M., Weaver, D. T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4123 · Cited by 1,060 · see citing works

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinković, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00300.2014 · Cited by 874 · see citing works

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

Barry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870 · see citing works

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine · doi:10.1038/nm.3282 · Cited by 866 · see citing works

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Kisseleva, T., Cong, M., Paik, Y., Scholten, D., Jiang, C., Benner, C., Iwaisako, K., Moore-Morris, T., Scott, B., Tsukamoto, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201840109 · Cited by 805 · see citing works

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

Liu, F., Mih, J. D., Shea, B. S., Kho, A. T., Sharif, A. S., Tager, A. M., & Tschumperlin, D. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004082 · Cited by 799 · see citing works

Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL

Vartiainen, M., Guettler, S., Larijani, B., & Treisman, R. (2007) · Science · doi:10.1126/science.1141084 · Cited by 672 · see citing works

BCL-2 family antagonists for cancer therapy

Lessène, G., Czabotar, P. E., & Colman, P. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2658 · Cited by 623 · see citing works

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737

Moore, V. D. G., Brown, J. R., Certo, M. V., Love, T. M., Novina, C. D., & Letai, A. G. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28281 · Cited by 604 · see citing works

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

Chonghaile, T. N., Sarosiek, K. A., Vo, T.-T. T., Ryan, J. A., Tammareddi, A., Moore, V. D. G., Deng, J., Anderson, K. C., Richardson, P. G. G., Tai, Y., et al. (2011) · Science · doi:10.1126/science.1206727 · Cited by 588 · see citing works

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

Parker, M. W., Rossi, D., Peterson, M., Smith, K. A., Sikström, K., White, E. S., Connett, J. E., Henke, C. A., Larsson, O. S., & Bitterman, P. B. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71386 · Cited by 552 · see citing works

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

Lin, L., Sabnis, A. J., Chan, E., Olivas, V., Cade, L., Pazarentzos, E., Asthana, S., Neel, D., Yan, J. J., Lu, X., et al. (2015) · Nature Genetics · doi:10.1038/ng.3218 · Cited by 551 · see citing works

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

Wong, V. W., Rustad, K. C., Akaishi, S., Sorkin, M., Glotzbach, J. P., Januszyk, M., Nelson, E. R., Levi, K., Paterno, J., Vial, I. N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2574 · Cited by 515 · see citing works

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

Troeger, J. S., Mederacke, I., Gwak, G., Dapito, D. H., Mu, X., Hsu, C. C., Pradere, J., Friedman, R. A., & Schwabe, R. F. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.036 · Cited by 515 · see citing works

BH3 Profiling Identifies Three Distinct Classes of Apoptotic Blocks to Predict Response to ABT-737 and Conventional Chemotherapeutic Agents

Deng, J., Carlson, N. E., Takeyama, K., Cin, P. D., Shipp, M. A., & Letai, A. G. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.07.001 · Cited by 513 · see citing works

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

Zhou, Y., Huang, X., Hecker, L., Kurundkar, D., Kurundkar, A., Liu, H., Jin, T. H., Desai, L. P., Bernard, K. F., & Thannickal, V. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66700 · Cited by 452 · see citing works

Animal Model of Sclerotic Skin. I: Local Injections of Bleomycin Induce Sclerotic Skin Mimicking Scleroderma

Yamamoto, T., Takagawa, S., Katayama, I., Yamazaki, K., Hamazaki, Y., Shinkai, H., & Nishioka, K. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00528.x · Cited by 434 · see citing works

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

Kim, N., & Gumbiner, B. M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201501025 · Cited by 423 · see citing works

Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy

Montero, J., Sarosiek, K. A., DeAngelo, J. D., Maertens, O., Ryan, J., Ercan, D., Piao, H., Horowitz, N. S., Berkowitz, R. S., Matulonis, U., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.042 · Cited by 378 · see citing works

Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML

Vo, T.-T. T., Ryan, J. A., Carrasco, R. D., Neuberg, D. S., Rossi, D. J., Stone, R. M., DeAngelo, D. J., Frattini, M. G., & Letai, A. G. (2012) · Cell · doi:10.1016/j.cell.2012.08.038 · Cited by 348 · see citing works

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

Li, C. X., Talele, N. P., Boo, S., Koehler, A., Knee‐Walden, E. J., Balestrini, J. L., Speight, P., Kapùs, A., & Hinz, B. (2016) · Nature Materials · doi:10.1038/nmat4780 · Cited by 335 · see citing works

Fibrosis—a lethal component of systemic sclerosis

Ho, Y. Y., Lagares, D., Tager, A. M., & Kapoor, M. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.53 · Cited by 307 · see citing works

Factors influencing myofibroblast differentiation during wound healing and fibrosis.

Desmoulière, A. (1995) · Cell Biology International · doi:10.1006/cbir.1995.1090 · Cited by 269 · see citing works

Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention

Van De Water, L., Varney, S., & Tomasek, J. J. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0393 · Cited by 251 · see citing works

Elasticity of Native and Cross-Linked Polyelectrolyte Multilayer Films

Richert, L., Engler, A. J., Discher, D. E., & Picart, C. (2004) · Biomacromolecules · doi:10.1021/bm0498023 · Cited by 247 · see citing works

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

Lagares, D., Busnadiego, Ó., García-Fernández, R. A., Kapoor, M., Liu, S., Carter, D. E., Abraham, D., Shiwen, X., Carreira, P. E., Fontaine, B. A., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33482 · Cited by 192 · see citing works

Molecular Signatures in Skin Associated with Clinical Improvement during Mycophenolate Treatment in Systemic Sclerosis

Hinchcliff, M., Huang, C.-C., Wood, T. A., Mahoney, J. M., Martyanov, V., Bhattacharyya, S., Tamaki, Z., Lee, J. J., Carns, M. A., Podlusky, S., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.130 · Cited by 186 · see citing works

BH3 profiling in whole cells by fluorimeter or FACS

Ryan, J. A., & Letai, A. G. (2013) · Methods · doi:10.1016/j.ymeth.2013.04.006 · Cited by 174 · see citing works

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma

Castelino, F. V., Seiders, J., Bain, G., Brooks, S. F., King, C. D., Swaney, J. S., Lorrain, D. S., Chun, J. J. M., Luster, A. D., & Tager, A. M. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30262 · Cited by 169 · see citing works

Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

Sisson, T. H., Ajayi, I. O., Subbotina, N., Dodi, A. E., Rodansky, E. S., Chibucos, L. N., Kim, K. K., Keshamouni, V. G., White, E. S., Zhou, Y., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.12.005 · Cited by 160 · see citing works

LPA 1 ‐induced cytoskeleton reorganization drives fibrosis through CTGF‐dependent fibroblast proliferation

Sakai, N., Chun, J. J. M., Duffield, J. S., Wada, T., Luster, A. D., & Tager, A. M. (2013) · The FASEB Journal · doi:10.1096/fj.12-219378 · Cited by 153 · see citing works

Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia

Davids, M. S., Deng, J., Wiestner, A. U., Lannutti, B. J., Wang, L., Wu, C. J., Wilson, W. H., Brown, J. R., & Letai, A. G. (2012) · Blood · doi:10.1182/blood-2012-02-414060 · Cited by 136 · see citing works

Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4 + CD8 + thymocytes

Ryan, J. A., Brunelle, J. K., & Letai, A. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914878107 · Cited by 128 · see citing works

Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis

Zhao, X., Yu, L., Cheng, M., Che, P., Lu, Y., Zhang, Q., Mu, M., Li, H., Zhu, L.-L., Zhu, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04317-0 · Cited by 128 · see citing works

Rho‐associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts

Akhmetshina, A., Dees, C., Pileckytė, M., Szűcs, G., Spriewald, B. M., Zwerina, J., Distler, O., Schett, G. A., & Distler, J. H. W. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23677 · Cited by 121 · see citing works

Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells

Wink, G., Ryan, J. A., Gullà, S. V., Letai, A. G., & Keating, A. E. (2014) · ACS Chemical Biology · doi:10.1021/cb500340w · Cited by 110 · see citing works

Loss of β1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model

Liu, S., Kapoor, M., Denton, C. P., Abraham, D., & Leask, A. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24801 · Cited by 92 · see citing works

MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts

Brunelle, J. K., Ryan, J. A., Yecies, D. W., Opferman, J. T., & Letai, A. G. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200904049 · Cited by 87 · see citing works

Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis

Lagares, D., García‐Fernández, R. A., Jiménez, C. L., Magán‐Marchal, N., Busnadiego, O., Lamas, S., & Rodríguez‐Pascual, F. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27307 · Cited by 80 · see citing works

Evaluation of the BH3-only Protein Puma as a Direct Bak Activator

Dai, H., Pang, Y., Ramı́rez-Alvarado, M., & Kaufmann, S. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.505701 · Cited by 73 · see citing works

Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts

Mimura, Y., Ihn, H., Jinnin, M., Asano, Y., Yamane, K., & Tamaki, K. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23701.x · Cited by 70 · see citing works

Targeted inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis and Preserves Heart Function in Adverse Cardiac Remodeling

Zhang, J., Fan, G., Zhao, H., Wang, Z., Li, F., Zhang, P., Zhang, J., Wang, X., & Wang, W. (2017) · Scientific Reports · doi:10.1038/srep43146 · Cited by 70 · see citing works

Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts

Shiwen, X., Thompson, K., Khan, K., Liu, S., Murphy‐Marshman, H., Baron, M. G., Denton, C. P., Leask, A., & Abraham, D. (2012) · Lara D. Veeken · doi:10.1093/rheumatology/kes234 · Cited by 65 · see citing works

Pioneering apoptosis-targeted cancer drug poised for FDA approval

Mullard, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.23 · Cited by 59 · see citing works

Platelet-derived Growth Factor Primes Cancer-associated Fibroblasts for Apoptosis

Ilyas, S. I., Mertens, J. C., Bronk, S. F., Hirsova, P., Dai, H., Roberts, L. R., Kaufmann, S. H., & Gores, G. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.563064 · Cited by 56 · see citing works

Targeting Focal Adhesion Kinase in Fibrotic Diseases

Lagares, D., & Kapoor, M. (2012) · BioDrugs · doi:10.1007/s40259-012-0003-4 · Cited by 51 · see citing works

Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1

Harrison, L., Micha, D., Brandenburg, M., Simpson, K., Morrow, C. J., Denneny, O., Hodgkinson, C. L., Yunus, Z., Dempsey, C. E., Roberts, D. L., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43505 · Cited by 50 · see citing works

Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase

Lagares, D., Busnadiego, O., García-Fernández, R. A., Lamas, S., & Rodríguez-Pascual, F. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0446oc · Cited by 40 · see citing works

Poissons' ratio of lung parenchyma and parenchymal interaction with bronchi.

Butler, J. P., Nakamura, M., Sasaki, H., Sasaki, T., & Takishima, T. (1986) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.36.91 · Cited by 30 · see citing works

Arg-Gly-Asp (RGD) peptide ameliorates carbon tetrachloride-induced liver fibrosis via inhibition of collagen production and acceleration of collagenase activity

Kotoh, K., Nakamuta, M., Kohjima, M., Fukushima, M., Morizono, S., Kobayashi, N., Enjoji, M., & Nawata, H. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.14.6.1049 · Cited by 21 · see citing works

Mitochondria as multifaceted regulators of cell death

Bock, F. J., & Tait, S. W. G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0173-8 · Cited by 2,482 · see citing works

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

Dey, A., Varelas, X., & Guan, K.-L. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0070-z · Cited by 860 · see citing works

Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases

Hinz, B., & Lagares, D. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0324-5 · Cited by 616 · see citing works

Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment

Liu, T., Zhou, L., Li, D., Andl, T., & Zhang, Y. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00060 · Cited by 446 · see citing works

Myofibroblasts and Fibrosis

Gibb, A., Lazaropoulos, M. P., & Elrod, J. W. (2020) · Circulation Research · doi:10.1161/circresaha.120.316958 · Cited by 443 · see citing works

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01153-w · Cited by 359 · see citing works

Cell Death in the Lung: The Apoptosis–Necroptosis Axis

Sauler, M., Bazan, I. S., & Lee, P. J. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114320 · Cited by 325 · see citing works

Revisiting fibrosis in inflammatory bowel disease: the gut thickens

D’Alessio, S., Ungaro, F., Noviello, D., Lovisa, S., Peyrin‐Biroulet, L., & Danese, S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00543-0 · Cited by 258 · see citing works

Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis

Tai, Y., Woods, E. L., Dally, J., Kong, D., Steadman, R., Moseley, R., & Midgley, A. C. (2021) · Biomolecules · doi:10.3390/biom11081095 · Cited by 244 · see citing works

The Role of Myofibroblasts in Physiological and Pathological Tissue Repair

Schuster, R., Younesi, F., Ezzo, M., & Hinz, B. (2023) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041231 · Cited by 232 · see citing works

Mitochondrial dysfunction in fibrotic diseases

Li, X., Zhang, W. Y., Cao, Q., Wang, Z., Zhao, M., Xu, L., & Zhuang, Q. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00316-9 · Cited by 226 · see citing works

Myofibroblast in Kidney Fibrosis: Origin, Activation, and Regulation

Yuan, Q., Tan, R. J., & Liu, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-8871-2_12 · Cited by 222 · see citing works

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Haak, A. J., Kostallari, E., Sicard, D., Ligresti, G., Choi, K. M., Caporarello, N., Jones, D. L., Tan, Q., Meridew, J. A., Espinosa, A. M. D., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau6296 · Cited by 219 · see citing works

Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence

Fletcher-Sananikone, E., Kanji, S., Tomimatsu, N., Di Cristofaro, L. F. M., Kollipara, R. K., Saha, D., Floyd, J. R., Sung, P., Hromas, R., Burns, T. C., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0752 · Cited by 212 · see citing works

Targeting Apoptosis in Cancer

Singh, P., & Lim, B. (2022) · Current Oncology Reports · doi:10.1007/s11912-022-01199-y · Cited by 212 · see citing works

Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

Walraven, M., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.020 · Cited by 194 · see citing works

Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans

Chung, L., Maestas, D. R., Lebid, A., Mageau, A., Rosson, G. D., Wu, X., Wolf, M. T., Tam, A. J., Vanderzee, I., Wang, X., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax3799 · Cited by 172 · see citing works

Clinical Review: Navitoclax as a Pro-Apoptotic and Anti-Fibrotic Agent

Anuar, N. N. M., Hisam, N. S. N., Liew, S. L., & Ugusman, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.564108 · Cited by 170 · see citing works

Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways

Suryadevara, V., Ramchandran, R., Kamp, D. W., & Natarajan, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124257 · Cited by 164 · see citing works

Pathophysiology of systemic sclerosis (scleroderma)

Rosendahl, A.-H., Schönborn, K., & Krieg, T. M. (2022) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12505 · Cited by 167 · see citing works

Unraveling SSc Pathophysiology; The Myofibroblast

van Caam, A., Vonk, M., van den Hoogen, F., van Lent, P., & van der Kraan, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02452 · Cited by 153 · see citing works

Cancer-Associated Fibroblasts: Understanding Their Heterogeneity

Louault, K., Li, R., & DeClerck, Y. A. (2020) · Cancers · doi:10.3390/cancers12113108 · Cited by 151 · see citing works

Mechano-therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma

Tschumperlin, D. J., & Lagares, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107575 · Cited by 142 · see citing works

Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis

Wiley, C. D., Brumwell, A. N., Davis, S. S., Jackson, J., Valdovinos, A., Calhoun, C., Alimirah, F., Castellanos, C. A., Ruan, R., Wei, Y., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.130056 · Cited by 132 · see citing works

Emerging targets of disease-modifying therapy for systemic sclerosis

Volkmann, E. R., & Varga, J. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0184-z · Cited by 129 · see citing works

Mechanisms for the Resolution of Organ Fibrosis

Horowitz, J. C., & Thannickal, V. J. (2018) · Physiology · doi:10.1152/physiol.00033.2018 · Cited by 130 · see citing works

Senotherapeutics: targeting senescence in idiopathic pulmonary fibrosis

Merkt, W., Bueno, M., Mora, A. L., & Lagares, D. (2020) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2019.12.008 · Cited by 119 · see citing works

Matrix Metalloproteinases and Their Inhibitors in Pulmonary Fibrosis: EMMPRIN/CD147 Comes into Play

Chuliá‐Peris, L., Carreres-Rey, C., Gabasa, M., Alcaraz, J., Carretero, J., & Pereda, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136894 · Cited by 121 · see citing works

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model

Tanner, L., Single, A., Bhongir, R. K. V., Heusel, M., Mohanty, T., Karlsson, C. A. Q., Pan, L., Clausson, C.-M., Bergwik, J., Wang, K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36314-5 · Cited by 110 · see citing works

Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis

Wang, Z., Chen, L., Huang, Y., Luo, M., Wang, H., Jiang, Z., Zheng, J., Yang, Z., Chen, Z., Zhang, C., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102082 · Cited by 90 · see citing works

The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype

Mebratu, Y. A., Soni, S., Rosas, L., Rojas, M. M., Horowitz, J. C., & Nho, R. S. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00124.2023 · Cited by 89 · see citing works

Long noncoding RNA H19X is a key mediator of TGF-β–driven fibrosis

Pachera, E., Assassi, S., Salazar, G. A., Stellato, M., Renoux, F., Wunderlin, A. S., Błyszczuk, P., Lafyatis, R., Kurreeman, F. A. S., de Vries‐Bouwstra, J., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135439 · Cited by 82 · see citing works

Extracellular Matrix Stiffness: Mechanotransduction and Mechanobiological Response-Driven Strategies for Biomedical Applications Targeting Fibroblast Inflammation

Tiskratok, W., Chuinsiri, N., Limraksasin, P., Kyawsoewin, M., & Jitprasertwong, P. (2025) · Polymers · doi:10.3390/polym17060822 · Cited by 87 · see citing works

Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation

Feng, Y., Wu, J., Sun, Z., Liu, S., Zou, M., Yuan, Z., Yu, S., Lv, G., & Yuan, F. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102715 · Cited by 79 · see citing works

Cardiovascular Disease: An Introduction

Thiriet, M. (2018) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-3-319-89315-0_1 · Cited by 77 · see citing works

Cellular Senescence in Lung Fibrosis

Hernández‐González, F., Faner, R., Rojas, M. M., Agustí, A. G. N., Serrano, M., & Sellarés, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137012 · Cited by 78 · see citing works

Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis

Cooley, J. C., Javkhlan, N., Wilson, J. A., Foster, D. G., Edelman, B., Ortiz, L. A., Schwartz, D. A., Riches, D. W. H., & Redente, E. F. (2023) · JCI Insight · doi:10.1172/jci.insight.163762 · Cited by 77 · see citing works

Fibroblast activation and heterogeneity in fibrotic disease

Zhang, X., Zhang, Y., & Liu, Y. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-00969-8 · Cited by 77 · see citing works

Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers

Louault, K., Bonneaud, T. L., Séveno, C., Gomez‐Bougie, P., Nguyen, F., Gautier, F., Bourgeois, N., Loussouarn, D., Kerdraon, O., Barillé‐Nion, S., et al. (2019) · Oncogene · doi:10.1038/s41388-018-0635-z · Cited by 72 · see citing works

A primer to traction force microscopy

Zancla, A., Mozetic, P., Orsini, M., Forte, G., & Rainer, A. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101867 · Cited by 65 · see citing works

Senolytic Agent Navitoclax Inhibits Angiotensin II-Induced Heart Failure in Mice

Jia, K., Dai, Y., Liu, A., Li, X., Wu, L., Lu, L., Bao, Y., & Jin, Q. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000878 · Cited by 67 · see citing works

Senescence and tissue fibrosis: opportunities for therapeutic targeting

O’Reilly, S., Tsou, P., & Varga, J. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.05.012 · Cited by 65 · see citing works

IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation

Chao, H.-Y., Zheng, L.-S., Hsu, P.-J., He, J.-Y., Wu, R.-D., Xu, S.-Q., Zeng, R., Zhou, Y., Ma, H., Liu, H.-B., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.157091 · Cited by 59 · see citing works

Matrix stiffness controls cardiac fibroblast activation through regulating YAP via AT 1 R

Niu, L., Jia, Y., Wu, M., Liu, H., Feng, Y., Hu, Y., Zhang, X., Gao, D., Xu, F., & Huang, G. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29678 · Cited by 59 · see citing works

Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents

Dańczak‐Pazdrowska, A., Gornowicz‐Porowska, J., Polańska, A., Krajka‐Kuźniak, V., Stawny, M., Gostyńska, A., Rubiś, B., Noureddine, S. A., Ashiqueali, S., Schneider, A., et al. (2023) · Aging Cell · doi:10.1111/acel.13845 · Cited by 63 · see citing works

The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration

Yuh, D., Maekawa, T., Li, X., Kajikawa, T., Bdeir, K. H., Chavakis, T., & Hajishengallis, G. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013024 · Cited by 58 · see citing works

Senescence under appraisal: hopes and challenges revisited

Davan-Wetton, C. S. A., Pessolano, E., Perretti, M., & Montero‐Melendez, T. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03746-x · Cited by 59 · see citing works

Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling

Gu, L., Surolia, R., Larson‐Casey, J. L., He, C., Davis, D., Kang, J., Antony, V. B., & Carter, A. B. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00840-w · Cited by 57 · see citing works

Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis

Zhou, S., Zhu, J., Zhou, P., & Gu, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.999600 · Cited by 57 · see citing works

Selective Targeting of Cancer-Associated Fibroblasts by Engineered H-Ferritin Nanocages Loaded with Navitoclax

Sitia, L., Bonizzi, A., Mazzucchelli, S., Negri, S., Sottani, C., Grignani, E., Rizzuto, M. A., Prosperi, D., Sorrentino, L., Morasso, C., et al. (2021) · Cells · doi:10.3390/cells10020328 · Cited by 56 · see citing works

Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice

Rehan, M., Kurundkar, D., Kurundkar, A., Logsdon, N. J., Smith, S. R., Chanda, D., Bernard, K. F., Sanders, Y. Y., Deshane, J. S., Dsouza, K. G., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00027-5 · Cited by 56 · see citing works

New promising drugs for the treatment of systemic sclerosis: pathogenic considerations, enhanced classifications, and personalized medicine

Lescoat, A., Varga, J., Matucci‐Cerinic, M., & Khanna, D. (2021) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2021.1923693 · Cited by 53 · see citing works

Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming

Merkt, W., Zhou, Y., Han, H., & Lagares, D. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12952 · Cited by 56 · see citing works

Fibroblast Activation Protein Alpha (FAPα) in Fibrosis: Beyond a Perspective Marker for Activated Stromal Cells?

Basalova, N. A., Alexandrushkina, N. A., Grigorieva, O., Kulebyakina, M., & Efimenko, A. Y. (2023) · Biomolecules · doi:10.3390/biom13121718 · Cited by 52 · see citing works

BH3 mimetics as anti-fibrotic therapy: Unleashing the mitochondrial pathway of apoptosis in myofibroblasts

Kühl, T., & Lagares, D. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.020 · Cited by 49 · see citing works

Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells

Lafontaine, J., Cardin, G. B., Malaquin, N., Boisvert, J.-S., Rodier, F., & Wong, P. (2021) · Cancers · doi:10.3390/cancers13030386 · Cited by 52 · see citing works

Cellular census of human fibrosis defines functionally distinct stromal cell types and states

Layton, T. B., Williams, L. M., McCann, F. E., Zhang, M., Fritzsche, M., Colin‐York, H., Cabrita, M., Ng, M., Feldmann, M., Sansom, S. N., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16264-y · Cited by 48 · see citing works

Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues

Dooling, L. J., Saini, K., Anlaş, A. A., & Discher, D. E. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.06.006 · Cited by 46 · see citing works

The anti-tumor growth effect of a novel agent DMAMCL in rhabdomyosarcoma in vitro and in vivo

Xu, N., Hua, Z., Ba, G., Zhang, S., Liu, Z., Thiele, C. J., & Li, Z. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1107-1 · Cited by 44 · see citing works

Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs); where do they stand in tumorigenesis and how they can change the face of cancer therapy?

Tajaldini, M., Saeedi, M., Amiriani, T., Amiriani, A., Sedighi, S., Zadeh, F. M., Dehghan, M. H., Jahanshahi, M., Zanjan, M. G., Khalili, P., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175087 · Cited by 46 · see citing works

Elimination of p19ARF‐expressing cells protects against pulmonary emphysema in mice

Mikawa, R., Suzuki, Y., Baskoro, H., Kanayama, K., Sugimoto, K., Sato, T., & Sugimoto, M. (2018) · Aging Cell · doi:10.1111/acel.12827 · Cited by 45 · see citing works

Cuprous oxide nanoparticles reduces hypertrophic scarring by inducing fibroblast apoptosis

Xiao, Y., Xu, D., Song, H., Shu, F., Pei, W., Yang, X., Zhong, C., Wang, X., Müller, W. E. G., Zheng, Y., et al. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s196794 · Cited by 44 · see citing works

Current and Potential New Targets in Systemic Sclerosis Therapy: a New Hope

Hinchcliff, M., & O’Reilly, S. (2020) · Current Rheumatology Reports · doi:10.1007/s11926-020-00918-3 · Cited by 41 · see citing works

Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues

Huang, M., Liu, Z., Baugh, L. M., DeFuria, J., Maione, A. G., Smith, A., Kashpur, O., Black, L. D., Georgakoudi, I., Whitfield, M. L., et al. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0159-8 · Cited by 39 · see citing works

Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase–like 4: New Evidence From Three‐Dimensional Skin‐like Tissues

Huang, M., Cai, G., Baugh, L. M., Liu, Z., Smith, A., Watson, M. C., Popovich, D., Zhang, T., Stawski, L., Trojanowska, M. E., et al. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41163 · Cited by 40 · see citing works

Thrown for a loop: fibro-adipogenic progenitors in skeletal muscle fibrosis

Loomis, T., & Smith, L. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00245.2023 · Cited by 39 · see citing works

Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis

Uceda-Castro, R., Margarido, A. S., Cornet, L., Vegna, S., Hahn, K., Song, J., Putavet, D. A., van Geldorp, M., Çitirikkaya, C. H., de Keizer, P. L. J., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100821 · Cited by 39 · see citing works

Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance

Tajaldini, M., Poorkhani, A., Amiriani, T., Amiriani, A., Javid, H., Aref, P., Ahmadi, F., Sadani, S., & Khori, V. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175991 · Cited by 38 · see citing works

Chronic lung diseases: prospects for regeneration and repair

Barnes, P. J., Anderson, G. P., Fagerås, M., & Belvisi, M. G. (2021) · European Respiratory Review · doi:10.1183/16000617.0213-2020 · Cited by 35 · see citing works

Upcoming treatments for morphea

Wenzel, D., Haddadi, N., Afshari, K., Richmond, J. M., & Rashighi, M. (2021) · Immunity Inflammation and Disease · doi:10.1002/iid3.475 · Cited by 36 · see citing works

Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases

Ezzo, M., & Hinz, B. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108528 · Cited by 37 · see citing works

Fibrosis in burns: an overview of mechanisms and therapies

Faour, S., Farahat, M., Aijaz, A., & Jeschke, M. G. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00254.2023 · Cited by 37 · see citing works

Unlocking the Therapeutic Potential of BCL-2 Associated Protein Family: Exploring BCL-2 Inhibitors in Cancer Therapy

Dakkak, B. E., Taneera, J., El‐Huneidi, W., Abu‐Gharbieh, E., Hamoudi, R., Semreen, M. H., Soares, N. C., Abu-rish, E. Y., Alkawareek, M. Y., Alkilany, A. M., et al. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2023.149 · Cited by 35 · see citing works

Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium

Bridges, J. P., Vladar, E. K., Kurche, J. S., Krivoi, A., Stancil, I. T., Dobrinskikh, E., Hu, Y., Sasse, S. K., Lee, J. S., Blumhagen, R. Z., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci183836 · Cited by 37 · see citing works

p53 and Myofibroblast Apoptosis in Organ Fibrosis

McElhinney, K., Irnaten, M., & O'Brien, C. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076737 · Cited by 33 · see citing works

Aging, senescence, and cutaneous wound healing—a complex relationship

O’Reilly, S., Markiewicz, E., & Idowu, O. C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1429716 · Cited by 39 · see citing works

Recent developments in the pathobiology of lung myofibroblasts

Jiang, D., Dey, T., & Liu, G. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1829972 · Cited by 34 · see citing works

Mitochondria at Center of Exchanges between Cancer Cells and Cancer-Associated Fibroblasts during Tumor Progression

Nocquet, L., Juin, P. P., & Souazé, F. (2020) · Cancers · doi:10.3390/cancers12103017 · Cited by 34 · see citing works

siRNA-mediated protein knockdown in precision-cut lung slices

Ruigrok, M. J. R., Xian, J. L., Frijlink, H. W., Melgert, B. N., Hinrichs, W. L. J., & Olinga, P. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.11.005 · Cited by 33 · see citing works

Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule

Vijayaraj, P., Minasyan, A., Durra, A., Karumbayaram, S., Mehrabi, M., Aros, C. J., Ahadome, S. D., Shia, D. W., Chung, K., Sandlin, J. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.019 · Cited by 33 · see citing works

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatmentPreprint

Hwang, W. L., Jagadeesh, K. A., Guo, J. A., Hoffman, H. I., Yadollahpour, P., Mohan, R. R., Drokhlyansky, E., Wittenberghe, N. V., Ashenberg, O., Farhi, S. L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.25.267336 · Cited by 33 · see citing works

Positive feedback loops between fibroblasts and the mechanical environment contribute to dermal fibrosis

Zhu, L., Liu, L., Wang, A., Liu, J., Huang, X., & Zan, T. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.05.001 · Cited by 36 · see citing works

A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX

Shen, M., Fu, J., Zhang, Y., Chang, Y., Li, X., Cheng, H., Qiu, Y., Shao, M., Han, Y., Zhou, Y., et al. (2024) · Aging Cell · doi:10.1111/acel.14229 · Cited by 33 · see citing works

Stress responses in stromal cells and tumor homeostasis

Vitale, I., Manic, G., Galassi, C., & Galluzzi, L. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.004 · Cited by 32 · see citing works

High-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation

Rehman, M., Vodret, S., Braga, L., Guarnaccia, C., Celsi, F., Rossetti, G., Martinelli, V. C., Battini, T., Long, C. S., Vukušić, K., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123987 · Cited by 31 · see citing works

You Say You Want a Resolution (of Fibrosis)

Atabai, K., Yang, C. D., & Podolsky, M. J. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0182tr · Cited by 30 · see citing works

Biological Hyperthermia-Inducing Nanoparticles for Specific Remodeling of the Extracellular Matrix Microenvironment Enhance Pro-Apoptotic Therapy in Fibrosis

Zhang, J., Ji, K., Ning, Y., Sun, L., Fan, M., Shu, C., Zhang, Z., Tu, T., Cao, J., Gao, F., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c12831 · Cited by 30 · see citing works

Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer

Al-Hilal, T. A., Chrysovergi, M.-A., Grasberger, P. E., Liu, F., Auernheimer, V., Zhou, Y., Xiao, Z., Duque, M. A. L., Santos, A., Islam, T., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01697-8 · Cited by 30 · see citing works

A model for positive feedback control of the transformation of fibroblasts to myofibroblasts

Elson, E. L., Qian, H., Fee, J. A., & Wakatsuki, T. (2018) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2018.08.004 · Cited by 30 · see citing works

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

Castro, N., Gillespie, S. R., & Bernstein, A. M. (2019) · Journal of Visualized Experiments · doi:10.3791/58562 · Cited by 30 · see citing works

Insights into myofibroblasts and their activation in scleroderma: opportunities for therapy?

Gyftaki-Venieri, D. A., Abraham, D., & Ponticos, M. (2018) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000543 · Cited by 29 · see citing works

Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention

Leong, E. K., Bezuhly, M., & Marshall, J. S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.727451 · Cited by 29 · see citing works

Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension

Wertheim, B. M., Wang, R., Guillermier, C., Hütter, C. V. R., Oldham, W. M., Menche, J., Steinhauser, M. L., & Maron, B. A. (2023) · JCI Insight · doi:10.1172/jci.insight.163932 · Cited by 29 · see citing works

Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis

Horowitz, J. C., Tschumperlin, D. J., Kim, K. K., Osterholzer, J. J., Subbotina, N., Ajayi, I. O., Teitz‐Tennenbaum, S., Virk, A. Q., Dotson, M. R., Liu, F., et al. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0039-1697953 · Cited by 29 · see citing works

Modulation of the antitumor immune response by cancer-associated fibroblasts: mechanisms and targeting strategies to hamper their immunosuppressive functions

Thiery, J. (2022) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2022.00103 · Cited by 28 · see citing works

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli

Dodi, A. E., Ajayi, I. O., Chang, C. J., BEARD, M., Ashley, S. L., Huang, S. K., Thannickal, V. J., Tschumperlin, D. J., Sisson, T. H., & Horowitz, J. C. (2018) · Respiratory Research · doi:10.1186/s12931-018-0801-4 · Cited by 27 · see citing works

ABT-263 Reduces Hypertrophic Scars by Targeting Apoptosis of Myofibroblasts

Yang, X., Xiao, Y., Zhong, C., Shu, F., Xiao, S., Zheng, Y., & Xia, Z. (2020) · Frontiers in Pharmacology · doi:10.2139/ssrn.3698857 · Cited by 28 · see citing works

Transcriptomic and Proteomic Changes Driving Pulmonary Fibrosis Resolution in Young and Old Mice

Weckerle, J., Mayr, C. H., Fundel‐Clemens, K., Lämmle, B., Boryń, Ł. M., Thomas, M. J., Bretschneider, T., Luippold, A. H., Huber, H. J., Viollet, C., et al. (2023) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0012oc · Cited by 26 · see citing works

Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing

Shvedova, M., Thanapaul, R. J. R. S., Ha, J., Dhillon, J., Shin, G. H., Crouch, J. D., Gower, A. C., Gritli, S., & Roh, D. S. (2024) · Aging · doi:10.18632/aging.206165 · Cited by 26 · see citing works

Network-based modeling of drug effects on disease module in systemic sclerosis

Kim, K., Moon, S., Park, K., & Tagkopoulos, I. (2020) · Scientific Reports · doi:10.1038/s41598-020-70280-y · Cited by 24 · see citing works

BH3 mimetics as anti-fibrotic therapy: Unleashing the mitochondrial pathway of apoptosis in myofibroblasts

Kühl, T., & Lagares, D. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.020 · Cited by 49 · see citing works

BH3 Mimetic Drugs for Anti-fibrotic Therapy

Lagares, D. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015783-00235

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

Park, J.-S., Oh, Y., Park, Y. J., Park, O., Yang, H. S., Slania, S., Hummers, L. K., Shah, A. A., An, H.-T., Jang, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09101-4 · Cited by 51 · see citing works

Methods for Studying Myofibroblast Apoptotic Pathways

Zhou, Y., & Lagares, D. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1382-5_9 · Cited by 4 · see citing works

Untitled work

Santiago (2001) · doi:10.1002/1529-0131(200107)44:7