Horikawa, Izumi

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

Michishita, E., Park, J. Y., Burneskis, J. M., Barrett, J. C., & Horikawa, I. (2005) · Molecular Biology of the Cell

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 1,364

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

Sedelnikova, O. A., Horikawa, I., Zimonjic, D. B., Popescu, N. C., Bonner, W. M., & Barrett, J. C. (2004) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 790

HIF-1α induces cell cycle arrest by functionally counteracting Myc

Koshiji, M., Kageyama, Y., Pete, E. A., Horikawa, I., Barrett, J. C., & Huang, L. E. (2004) · The EMBO Journal

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 652

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers

Seike, M., Goto, A., Okano, T., Bowman, E. D., Schetter, A. J., Horikawa, I., Mathe, E. A., Jen, J., Yang, P., Sugimura, H., et al. (2009) · Proceedings of the National Academy of Sciences

MicroRNA in disease regulationLung Cancer Treatments and Mutations

Cited by 500

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

Fujita, K., Mondal, A. M., Horikawa, I., Nguyen, G. H., Kumamoto, K., Sohn, J. J., Bowman, E. D., Mathe, E. A., Schetter, A. J., Pine, S. R., et al. (2009) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 336

Delayed kinetics of DNA double‐strand break processing in normal and pathological aging

Sedelnikova, O. A., Horikawa, I., Redon, C., Nakamura, A., Zimonjic, D. B., Popescu, N. C., & Bonner, W. M. (2008) · Aging Cell

DNA Repair MechanismsTelomeres, Telomerase, and Senescence

Cited by 207

Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis

Miura, N., Horikawa, I., Nishimoto, A., Ohmura, H., Ito, H., Hirohashi, S., Shay, J. W., & Oshimura, M. (1997) · Cancer Genetics and Cytogenetics

Telomeres, Telomerase, and SenescenceLiver physiology and pathology

Cited by 174

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

Nakamura, A. J., Chiang, Y. J., Hathcock, K. S., Horikawa, I., Sedelnikova, O. A., Hodes, R. J., & Bonner, W. M. (2008) · Epigenetics & Chromatin

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 168

Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence

Tang, Y., Horikawa, I., Ajiro, M., Robles, A. I., Fujita, K., Mondal, A. M., Stauffer, J. K., Zheng, Z.-M., & Harris, C. C. (2013) · Oncogene

RNA Research and SplicingTelomeres, Telomerase, and Senescence

Cited by 165

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

Mondal, A. M., Horikawa, I., Pine, S. R., Fujita, K., Morgan, K. M., Vera, E., Mazur, S. J., Appella, E., Vojtesek, B., Blasco, M. A., et al. (2013) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 164

Radiation-induced astrocyte senescence is rescued by Δ133p53

Turnquist, C., Beck, J. A., Horikawa, I., Obiorah, I. E., Von Muhlinen, N., Vojtesek, B., Lane, D. P., Grunseich, C., Chahine, J. J., Ames, H. M., et al. (2019) · Neuro-Oncology

Telomeres, Telomerase, and SenescenceEffects of Radiation Exposure

Cited by 118