Nakabeppu, Yusaku

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., & Yamamoto, K.-I. (1999) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 279

Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., et al. (2017) · Scientific Reports

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 158

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

Abolhassani, N., Leon, J., Sheng, Z., Oka, S., Hamasaki, H., Iwaki, T., & Nakabeppu, Y. (2017) · Mechanisms of Ageing and Development

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 140

8-Oxoguanine Formation Induced by Chronic UVB Exposure Makes Ogg1 Knockout Mice Susceptible to Skin Carcinogenesis

Kunisada, M., Sakumi, K., Tominaga, Y., Budiyanto, A., Ueda, M., Ichihashi, M., Nakabeppu, Y., & Nishigori, C. (2005) · Cancer Research

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 135

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis

Oka, S., & Nakabeppu, Y. (2011) · Cancer Science

DNA Repair MechanismsGenetic factors in colorectal cancer

Cited by 84

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer’s disease

Oka, S., Leon, J., Sakumi, K., Ide, T., Kang, D., LaFerla, F. M., & Nakabeppu, Y. (2016) · Scientific Reports

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 78

Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia: Fosb Regulates Expression of C5a Receptors

Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J., & Nakabeppu, Y. (2014) · Glia

Neuroinflammation and Neurodegeneration MechanismsComplement system in diseases

Cited by 68

Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis

Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y., & Nishigori, C. (2014) · Journal of Investigative Dermatology

Skin Protection and AgingSeaweed-derived Bioactive Compounds

Cited by 64

Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis

Akatsuka, S., Aung, T. T., Dutta, K. K., Jiang, L., Lee, W.-H., Liu, Y.-T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., et al. (2006) · The American Journal of Pathology

Carcinogens and Genotoxicity AssessmentDNA Repair Mechanisms

Cited by 51

MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer’s brain, and prevent the progression of Alzheimer’s pathogenesis

Oka, S., Leon, J., Sakumi, K., Abolhassani, N., Sheng, Z., Tsuchimoto, D., LaFerla, F. M., & Nakabeppu, Y. (2021) · Scientific Reports

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 51

Down‐regulation of MET in hippocampal neurons of Alzheimer's disease brains

Hamasaki, H., Honda, H., Suzuki, S. O., Hokama, M., Kiyohara, Y., Nakabeppu, Y., & Iwaki, T. (2014) · Neuropathology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 33

MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model

Sakamoto, H., Miyanishi, K., Tanaka, S., Ito, R., Hamaguchi, K., Sakurada, A., Sato, M., Kubo, T., Osuga, T., Murase, K., et al. (2021) · Scientific Reports

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 8

Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice

Funahashi, S., Okazaki, Y., Akatsuka, S., Takahashi, T., Sakumi, K., Nakabeppu, Y., & Toyokuni, S. (2020) · Free Radical Research

Occupational and environmental lung diseasesDNA Repair Mechanisms

Cited by 7