MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer’s brain, and prevent the progression of Alzheimer’s pathogenesis

Oxidants, antioxidants, and the degenerative diseases of aging.

Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885 · see citing works

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303 · see citing works

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.040 · Cited by 1,294 · see citing works

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

Kasai, H., & Nishimura, S. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.4.2137 · Cited by 948 · see citing works

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

Yao, J., Irwin, R. W., Zhao, L., Nilsen, J., Hamilton, R. T., & Brinton, R. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903563106 · Cited by 940 · see citing works

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870 · see citing works

Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons

Schmued, L. C., Stowers, C. C., Scallet, A. C., & Xu, L. (2005) · Brain Research · doi:10.1016/j.brainres.2004.11.054 · Cited by 633 · see citing works

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

Guo, Q., Fu, W., Sopher, B. L., Miller, M. W., Ware, C. B., Martin, G. M., & Mattson, M. P. (1999) · Nature Medicine · doi:10.1038/4789 · Cited by 489 · see citing works

Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease

Gabbita, S. P., Lovell, M. A., & Markesbery, W. R. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71052034.x · Cited by 479 · see citing works

The Human OGG1 Gene: Structure, Functions, and Its Implication in the Process of Carcinogenesis

Boiteux, S., & Radicella, J. P. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1773 · Cited by 478 · see citing works

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

Leuner, K., Schütt, T., Kurz, C., Eckert, S. H., Schiller, C., Occhipinti, A., Mai, S., Jendrach, M., Eckert, G. P., Kruse, S. E., et al. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4173 · Cited by 354 · see citing works

Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study

Hokama, M., Oka, S., Leon, J., Ninomiya, T., Honda, H., Sasaki, K., Iwaki, T., Ohara, T., Sasaki, T., LaFerla, F. M., et al. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht101 · Cited by 319 · see citing works

Oxidative and nitrative stress in neurodegeneration

Cobb, C. A., & Cole, M. P. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.020 · Cited by 300 · see citing works

Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased Levels of Transthyretin and the Activation of Cell Survival Pathways

Stein, T. D., & Johnson, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07380.2002 · Cited by 288 · see citing works

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

Tsuzuki, T., Egashira, A., Igarashi, H., Iwakuma, T., Nakatsuru, Y., Tominaga, Y., Kawate, H., Nakao, K., Nakamura, K. D., Ide, F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191086798 · Cited by 287 · see citing works

Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.

Sakumi, K., Tominaga, Y., Furuichi, M., Xu, P., Tsuzuki, T., Sekiguchi, M., & Nakabeppu, Y. (2003) · PubMed · Cited by 237 · see citing works

Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease

de la Monte, S. M., Luong, T., Neely, T. R., Robinson, D., & Wands, J. R. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780140 · Cited by 227 · see citing works

Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells

Nakabeppu, Y. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150712543 · Cited by 206 · see citing works

Functional mitochondria are required for amyloid β‐mediated neurotoxicity

Cardoso, S. M., Santos, S., Swerdlow, R. H., & Oliveira, C. R. (2001) · The FASEB Journal · doi:10.1096/fj.00-0561fje · Cited by 203 · see citing works

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?

Bordt, E. A., & Polster, B. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.033 · Cited by 202 · see citing works

Microglia Proliferation Is Regulated by Hydrogen Peroxide from NADPH Oxidase

Mander, P. K., Jekabsone, A., & Brown, G. C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.1046 · Cited by 198 · see citing works

Transthyretin binding to A‐Beta peptide – Impact on A‐Beta fibrillogenesis and toxicity

Costa, A. R., Gonçalves, A., Saraiva, M. J., & Cardoso, I. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.02.034 · Cited by 152 · see citing works

Ratio of 8-Hydroxyguanine in Intact DNA to Free 8-Hydroxyguanine Is Increased in Alzheimer Disease Ventricular Cerebrospinal Fluid

Lovell, M. A., & Markesbery, W. R. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.392 · Cited by 150 · see citing works

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Sheng, Z., Oka, S., Tsuchimoto, D., Abolhassani, N., Nomaru, H., Sakumi, K., Yamada, H., & Nakabeppu, Y. (2012) · Journal of Clinical Investigation · doi:10.1172/jci65053 · Cited by 146 · see citing works

Learning Decreases Aβ*56 and Tau Pathology and Ameliorates Behavioral Decline in 3xTg-AD Mice

Billings, L. M., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4800-06.2007 · Cited by 138 · see citing works

Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain

Iida, T., Furuta, A., Nishioka, K., Nakabeppu, Y., & Iwaki, T. (2001) · Acta Neuropathologica · doi:10.1007/s004010100418 · Cited by 135 · see citing works

Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain

Lovell, M. A., Soman, S., & Bradley, M. A. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.08.003 · Cited by 124 · see citing works

Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Mao, G., Pan, X., Zhu, B., Zhang, Y., Yuan, F., Huang, J. V., Lovell, M. A., Lee, M. P., Markesbery, W. R., Li, G., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm189 · Cited by 124 · see citing works

Glial Neurobiology

Verkhratsky, A., & Butt, A. M. (2007) · Wiley eBooks · doi:10.1002/9780470517796 · Cited by 124 · see citing works

Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes

Yoon, S.-Y., Patel, D. R., & Dougherty, P. M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.024 · Cited by 98 · see citing works

Oxoguanine Glycosylase 1 Protects Against Methamphetamine-Enhanced Fetal Brain Oxidative DNA Damage and Neurodevelopmental Deficits

Wong, A. W., McCallum, G. P., Jeng, W., & Wells, P. G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2557-08.2008 · Cited by 96 · see citing works

8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions

Leon, J., Sakumi, K., Castillo, E., Sheng, Z., Oka, S., & Nakabeppu, Y. (2016) · Scientific Reports · doi:10.1038/srep22086 · Cited by 94 · see citing works

Oxidatively modified RNA in mild cognitive impairment

Lovell, M. A., & Markesbery, W. R. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.07.030 · Cited by 93 · see citing works

MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Yamaguchi, H., Kajitani, K., Dan, Y., Furuichi, M., Ohno, M., Sakumi, K., Kang, D., & Nakabeppu, Y. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401788 · Cited by 85 · see citing works

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer’s disease

Oka, S., Leon, J., Sakumi, K., Ide, T., Kang, D., LaFerla, F. M., & Nakabeppu, Y. (2016) · Scientific Reports · doi:10.1038/srep37889 · Cited by 78 · see citing works

Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration

Chen, S.-H., Oyarzabal, E. A., & Hong, J.-S. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.10.001 · Cited by 76 · see citing works

Quantitative Analysis of Oxidized Guanine, 8-Oxoguanine, in Mitochondrial DNA by Immunofluorescence Method

Ohno, M., Oka, S., & Nakabeppu, Y. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-521-3_13 · Cited by 70 · see citing works

MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?

Nakabeppu, Y., Ohta, E., & Abolhassani, N. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.002 · Cited by 68 · see citing works

MTH1, an Oxidized Purine Nucleoside Triphosphatase, Suppresses the Accumulation of Oxidative Damage of Nucleic Acids in the Hippocampal Microglia during Kainate-Induced Excitotoxicity

Kajitani, K., Yamaguchi, H., Dan, Y., Furuichi, M., Kang, D., & Nakabeppu, Y. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4948-05.2006 · Cited by 61 · see citing works

Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis

Silva, C. S., Eira, J., Ribeiro, C. A., Oliveira, Â., Sousa, M. M., Cardoso, I., & Liz, M. A. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.07.002 · Cited by 59 · see citing works

Expression of hMTH1 in the hippocampi of control and Alzheimer's disease

Furuta, A., Iida, T., Nakabeppu, Y., & Iwaki, T. (2001) · Neuroreport · doi:10.1097/00001756-200109170-00028 · Cited by 51 · see citing works

Ogg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP

Cardozo‐Pelaez, F., Sánchez-Contreras, M., & Nevin, A. B. C. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.06.013 · Cited by 50 · see citing works

The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice

Hyun, D. H., Mughal, M. R., Yang, H., Lee, J. H., Ko, E. J., Hunt, N. D., de Cabo, R., & Mattson, M. P. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.07.020 · Cited by 39 · see citing works

Ovarian Cycle Stages Modulate Alzheimer-Related Cognitive and Brain Network Alterations in Female Mice

Broestl, L., Worden, K., Moreno, A. J., Davis, E. J., Wang, D., Garay, B. I., Singh, T., Verret, L., Palop, J. J., & Dubal, D. B. (2018) · eNeuro · doi:10.1523/eneuro.0132-17.2018 · Cited by 33 · see citing works

Characterization of changes in global gene expression in the brain of neuron-specific enolase/human Tau23 transgenic mice in response to overexpression of Tau protein

Hwang (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000390 · Cited by 25 · see citing works

Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer’s Disease Brain

Nakabeppu, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_3 · Cited by 20 · see citing works

8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes

Haruyama, N., Sakumi, K., Katogi, A., Tsuchimoto, D., Luca, G. D., Bignami, M., & Nakabeppu, Y. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.04.002 · Cited by 13 · see citing works

Neurodegeneration Caused by Accumulation of an Oxidized Base Lesion, 8-oxoguanine, in Nuclear and Mitochondrial DNA: From Animal Models to Human Diseases

Nakabeppu, Y. (2016) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814719735_0015 · Cited by 7 · see citing works

General Pathophysiology of Glia

Verkhratsky, A., & Butt, A. M. (2007) · doi:10.1002/9780470517796.ch9 · Cited by 2 · see citing works

Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery

Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model

Tanner, L., Single, A., Bhongir, R. K. V., Heusel, M., Mohanty, T., Karlsson, C. A. Q., Pan, L., Clausson, C.-M., Bergwik, J., Wang, K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36314-5 · Cited by 110 · see citing works

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

Michel, M., Benitéz‐Buelga, C., Calvo, P. A., Hanna, B. M. F., Mortusewicz, O., Masuyer, G., Davies, J. R., Wallner, O. A., Sanjiv, K., Albers, J. J., et al. (2022) · Science · doi:10.1126/science.abf8980 · Cited by 86 · see citing works

Oxidative stress–mediated neuroinflammation in Alzheimer’s disease

Firdous, S. M., Khan, S. A., & Maity, A. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03188-3 · Cited by 85 · see citing works

Hyperoside Attenuate Inflammation in HT22 Cells via Upregulating SIRT1 to Activities Wnt/β-Catenin and Sonic Hedgehog Pathways

Huang, J., Zhou, L., Chen, J., Chen, T., Lei, B., Zheng, N., Wan, X., Xu, J., & Wang, T. (2021) · Neural Plasticity · doi:10.1155/2021/8706400 · Cited by 44 · see citing works

OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage

Zhong, Y., Zhang, X., Feng, R., Fan, Y., Zhang, Z., Zhang, Q., Wan, J., Wang, Y., Yu, H., & Li, G. (2024) · Medicinal Research Reviews · doi:10.1002/med.22068 · Cited by 42 · see citing works

MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer’s Disease

Mizuno, Y., Abolhassani, N., Mazzei, G., Sakumi, K., Saito, T., Saido, T. C., Ninomiya, T., Iwaki, T., Yamasaki, R., Kira, J., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8635088 · Cited by 41 · see citing works

Exploring the Causal Relationship Between Telomere Biology and Alzheimer’s Disease

Kuan, X.-Y., Fauzi, N. S. A., Ng, K. Y., & Bakhtiar, A. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03337-4 · Cited by 35 · see citing works

Role of MTH1 in oxidative stress and therapeutic targeting of cancer

Taiyab, A., Ashraf, A., Sulaimani, M. N., Rathi, A., Shamsi, A., & Hassan, M. I. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103394 · Cited by 30 · see citing works

8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?

Kruchinin, A. A., Kamzeeva, P. N., Zharkov, D. O., Aralov, A. V., & Makarova, А. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021342 · Cited by 22 · see citing works

Oxidative DNA Damage: A Role in Altering Neuronal Function

Behrouzi, A., Kelley, M. R., & Fehrenbacher, J. C. (2022) · Journal of Cellular Signaling · doi:10.33696/signaling.3.079 · Cited by 17 · see citing works

Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction

de Sousa, M. M. L., Ye, J., Luna, L., Hildrestrand, G. A., Bjørås, K. Ø., Scheffler, K., & Bjørås, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312924 · Cited by 16 · see citing works

Transcriptional mutagenesis of α-synuclein caused by DNA oxidation in Parkinson’s disease pathogenesis

Basu, S., Song, M., Adams, L., Jeong, I., Je, G., Guhathakurta, S., Jiang, J. B., Boparai, N., Dai, W., Cardozo‐Pelaez, F., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02632-7 · Cited by 16 · see citing works

Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations

You, Q., Feng, X., Cai, Y., Baylin, S. B., & Li, H. (2024) · Communications Biology · doi:10.1038/s42003-024-06919-7 · Cited by 15 · see citing works

Synthetic switches of OGG1 control initiation of base excision repair and offer new treatment strategies

Benitéz‐Buelga, C., Helleday, T., & Michel, M. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1035 · Cited by 13 · see citing works

The role of DNA and RNA guanosine oxidation in cardiovascular diseases

Li, Y., & Wang, X. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107187 · Cited by 13 · see citing works

Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP‐Lyase Function

Kehler, M., Zhou, K., Kemas, A. M., del Prado, A., Scaletti, E. R., Nairn, E. H., Varga, M., Plattner, Y., Zhong, Y., Purewal-Sidhu, O., et al. (2025) · Chemistry - A European Journal · doi:10.1002/chem.202500382 · Cited by 13 · see citing works

Modulation of OGG1 enzymatic activities by small molecules, promising tools and current challenges

Renaudin, X., & Campalans, A. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103827 · Cited by 12 · see citing works

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1

Hank, E. C., D’Arcy-Evans, N. D., Scaletti, E. R., Benitéz‐Buelga, C., Wallner, O. A., Ortis, F., Zhou, K., Meng, L., del Prado, A., Calvo, P., et al. (2025) · RSC Chemical Biology · doi:10.1039/d4cb00323c · Cited by 12 · see citing works

Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer’s disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior

Mizuno, Y., Abolhassani, N., Mazzei, G., Saito, T., Saido, T. C., Yamasaki, R., Kira, J., & Nakabeppu, Y. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.11.009 · Cited by 12 · see citing works

Alzheimer's disease as an auto-innate immune pathology with potential cell trans-differentiation and enhanced trained immunity in 3xTg-AD mouse model

Saaoud, F., Liu, L., Xu, K., Lu, Y., Shao, Y., Issa, M., Jiang, X., Wang, X., Liu, X., Autieri, M. V., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251329583 · Cited by 11 · see citing works

IKKα affects the susceptibility of primary human osteoarthritis chondrocytes to oxidative stress-induced DNA damage by tuning autophagy

Neri, S., Guidotti, S., Panichi, V., Minguzzi, M., Cattini, L., Platano, D., Ursini, F., Arciola, C. R., & Borzı̀, R. M. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.299 · Cited by 9 · see citing works

Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1

Varga, M., Ortis, F., del Prado, A., Eddershaw, A., Scaletti, E. R., Hank, E. C., Zhou, K., Rudolfová, N., Dodaro, A., Wiita, E., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01454 · Cited by 9 · see citing works

Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease

Egiazarian, M. A., Strømstad, S., Sakshaug, T., Nunez-Nescolarde, A. B., Bethge, N., Bjørås, M., & Scheffler, K. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.020 · Cited by 8 · see citing works

NUDT1 aggravates intestinal epithelial barrier injury through oxidative stress in ulcerative colitis

Jin, G., Gao, X., Dai, F., Zhang, H., Lu, T., Jing, D., Yang, Y., Zhu, F., & Zhou, G. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114634 · Cited by 7 · see citing works

Interplay of oxidative stress and neuroinflammation in alzheimer’s: insights into age-driven pathogenesis

Firdous, S. M., Chakrabortty, S., Undale, V., Mallik, S., & Gouda, M. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02169-7 · Cited by 6 · see citing works

Targeting MutT Homolog 1 (MTH1) for Breast Cancer Suppression by Using a Novel MTH1 Inhibitor MA−24 with Tumor-Selective Toxicity

Kang, N., Ma, J., Hu, Y., Di, R., Wang, L., Zhang, X., Lai, Y., & Liu, Y. (2024) · Pharmaceuticals · doi:10.3390/ph17030291 · Cited by 6 · see citing works

World no-tobacco: effects of second-hand smoke (SHS) and vapors on the developing and adult brain

Kisby, G. E., & Raber, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1466332 · Cited by 6 · see citing works

NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling

Fernández-Berrocal, M. S., Reis, A., Rolseth, V., Suganthan, R., Kuśnierczyk, A., França, A. S. C., Soares, A. Y. M., Kunath, N., Bugaj, A. M., Abentung, A., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05629-5 · Cited by 5 · see citing works

Neuropathological Examination of Mice Chronically Exposed to Secondhand Smoke

Lopes, L. A., Davenport, C., Torres, E. R., Chlebowski, A. C., Mikami, A., Raber, J., Torres, E. R. S., & Kisby, G. E. (2023) · Military Medicine · doi:10.1093/milmed/usad247 · Cited by 5 · see citing works

Microglial inflammation in genome instability: A neurodegenerative perspective

Maliar, N. L., Talbot, E., Edwards, A. R., & Khoronenkova, S. V. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103634 · Cited by 5 · see citing works

Mitochondrial and Nuclear DNA Variants in Amyotrophic Lateral Sclerosis: Enrichment in the Mitochondrial Control Region and Sirtuin Pathway Genes in Spinal Cord Tissue

Cox, S. N., Giudice, C. L., Lavecchia, A., Poeta, M. L., Chiara, M., Picardi, E., & Pesole, G. (2024) · Biomolecules · doi:10.3390/biom14040411 · Cited by 5 · see citing works

Novel Techniques for Mapping DNA Damage and Repair in the Brain

Hedlich-Dwyer, J., Allard, J. S., Mulgrave, V. E., Kisby, G. E., Raber, J., & Gassman, N. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137021 · Cited by 4 · see citing works

Increased nucleotide metabolism alleviates Alzheimer’s disease pathology

Yu, Y., Miller, M. B., Huang, A. Y., Tan, B. W. Z., Celardo, I., Leal, N. S., Loh, S. H. Y., & Martins, L. M. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08066-1 · Cited by 4 · see citing works

Adaptive and Maladaptive DNA Breaks in Neuronal Physiology and Alzheimer’s Disease

Roberts, A., Swerdlow, R. H., & Wang, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147774 · Cited by 4 · see citing works

Effect of kynurenic acid on enzymatic activity of the DNA base excision repair pathway in specific areas of the sheep brain

Młotkowska, P., Misztal, T., Kowalczyk, P., & Marciniak, E. (2024) · Scientific Reports · doi:10.1038/s41598-024-66094-x · Cited by 4 · see citing works

Esculetin inhibits ferroptosis after ICH by promoting NUDT1-mediated m7G methylation modification of GPX4

Gong, J., Zhang, Z., Li, L., Mei, Z., & Chen, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-16869-7 · Cited by 3 · see citing works

Noradrenaline Protects Human Microglial Cells (HMC3) Against Apoptosis and DNA Damage Induced by LPS and Aβ1-42 Aggregates In Vitro

Barczuk, J., Galita, G., Siwecka, N., Golberg, M., Saramowicz, K., Granek, Z., Wiese, W., Majsterek, I., & Rozpędek‐Kamińska, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111399 · Cited by 3 · see citing works

Molecular Duality of OGG1: From Genomic Guardian to Redox-Sensitive Modulator in Diseases

Zhong, R., Zhang, W., Qu, X., Xiang, Y., & Ji, M. (2025) · Antioxidants · doi:10.3390/antiox14080980 · Cited by 2 · see citing works

Sequential release of MTH1 inhibitor and chemotherapeutic drug using a pH-sensitive polymeric delivery system induces apoptosis in human tongue squamous cell carcinoma CAL-27 cells in vitro

Bowen, Z., Cuicui, Y., Haoran, Q., Ma, H., & Changsheng, S. (2025) · World Journal of Surgical Oncology · doi:10.1186/s12957-025-04047-y · Cited by 1 · see citing works

High-Frequency, Low-Intensity Pulsed Electric Field and N-Acetylcysteine Synergistically Protect SH-SY5Y Cells Against Hydrogen Peroxide-Induced Cell Damage In Vitro

Hsu, F.-T., Kuo, Y.-Y., & Chao, C. (2025) · Antioxidants · doi:10.3390/antiox14101267 · Cited by 1 · see citing works

ZBP1 in Neuroinflammation and Neurodegeneration: Z-Nucleic-Acid Sensing, RHIM Signalling and Therapeutic Targeting

Șerban, M., Toader, C., & Covache-Busuioc, R.-A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167478 · Cited by 1 · see citing works

Expression of nucleic acid oxidation metabolites 8-Oxo-GSn and β-amyloid protein in the urine and cerebral tissues of diabetic rats

Cai, H., Wang, W., Li, M., Jing, J., & Ge, Z. (2022) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2021.101776 · Cited by 1 · see citing works

MTH1 in the disorders of the central nervous system: scope beyond brain tumors and challenges

Padmakumar, L., Menon, R. N., Gopala, S., & Vilanilam, G. C. (2025) · Acta Neurologica Belgica · doi:10.1007/s13760-025-02747-6 · Cited by 1 · see citing works

Mitochondrial DNA release mediates metabolic-associated steatohepatitis via activation of inflammatory pathways

Liu, Y., Hu, Y., & Shan, Z. (2025) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v33.i5.344 · Cited by 1 · see citing works

Photochemical pathways of 8-oxo-2′-deoxyguanosine under photodegradation

Park, T., Lee, I., Son, S.-J., Na, Y., & Ko, D. (2022) · AIP Advances · doi:10.1063/5.0063641

Animal models of second-hand cigarette smoke (SHS) exposure in neurodevelopmental disorders and neurodegenerative disease

Kisby, G. E., & Raber, J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29090-9.00021-0

The role and therapeutic potential of DNA glycosylases in Alzheimer's disease

Zhao, X., Li, Y., Meng, Z., Xu, X., Chen, L., Yu, Q., Wang, R., Ren, Y., Chen, F., Ai, Q., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103129

Impact de la déficience de NEIL1 sur l'inflammation médiée par la voie des senseurs des ADNs cytosoliques

Wanschoor, P. (2024) · theses.fr (ABES) · doi:10.70675/614376b0zfaeaz4c04zb17cz1a95b6904fe2

Combined effect of baicalein and thermal-cycling stimulation on suppressing non-small cell lung cancer A549 cells under CoCl 2 -induced hypoxiaPreprint

Wang, Y., Lin, G.-B., Hsu, F.-T., Kuo, Y.-Y., Chen, Y.-H., & Chao, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.11.744169

Targeting the mitochondrial functional network: Decoding upstream pathological mechanisms and novel therapeutic paradigms for Alzheimer’s disease

Li, X., Wan, R., Wu, Y., Zhao, Y., Chen, X., Li, Y., Yang, R., Zhang, D., Li, Q., & Luo, C. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103359

Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer’s disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior

Mizuno, Y., Abolhassani, N., Mazzei, G., Saito, T., Saido, T. C., Yamasaki, R., Kira, J., & Nakabeppu, Y. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.11.009 · Cited by 12 · see citing works

Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain

Iida, T., Furuta, A., Nishioka, K., Nakabeppu, Y., & Iwaki, T. (2001) · Acta Neuropathologica · doi:10.1007/s004010100418 · Cited by 135 · see citing works

Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer’s disease brain

Shao, C., Xiong, S., Li, G.-M., Gu, L., Mao, G., Markesbery, W. R., & Lovell, M. A. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.06.003 · Cited by 114 · see citing works

Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Mao, G., Pan, X., Zhu, B., Zhang, Y., Yuan, F., Huang, J. V., Lovell, M. A., Lee, M. P., Markesbery, W. R., Li, G., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm189 · Cited by 124 · see citing works

MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer’s Disease

Mizuno, Y., Abolhassani, N., Mazzei, G., Sakumi, K., Saito, T., Saido, T. C., Ninomiya, T., Iwaki, T., Yamasaki, R., Kira, J., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8635088 · Cited by 41 · see citing works