Chen, Xi

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

Lehmann, B. D., Bauer, J. A., Chen, X., Sanders, M. E., Chakravarthy, A. B., Shyr, Y., & Pietenpol, J. A. (2011) · Journal of Clinical Investigation

Breast Cancer Treatment StudiesBreast Lesions and Carcinomas

Cited by 5,592

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

Ye, J., Rawson, R. B., Komuro, R., Chen, X., Davé, U. P., Prywes, R., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell

Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors

Cited by 1,871

Endoplasmic reticulum stress signals in the tumour and its microenvironment

Chen, X., & Cubillos-Ruiz, J. R. (2021) · Nature Reviews Cancer

Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors

Cited by 1,356

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 1,303

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

Martinon, F., Chen, X., Lee, A.-H., & Glimcher, L. H. (2010) · Nature Immunology

Immune Response and InflammationEndoplasmic Reticulum Stress and Disease

Cited by 996

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

Gillette, M. A., Satpathy, S., Cao, S., Dhanasekaran, S. M., Vasaikar, S. V., Krug, K., Petralia, F., Li, Y., Liang, W.-W., Reva, B., et al. (2020) · Cell

Lung Cancer Treatments and MutationsLung Cancer Research Studies

Cited by 820

Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes

Chen, K., Chen, Z., Wu, D., Zhang, L., Lin, X., Su, J., Rodriguez, B., Xi, Y., Xia, Z., Chen, X., et al. (2015) · Nature Genetics

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 373

Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses

Jiang, Y., Li, C., Wu, Q., An, P., Huang, L., Wang, J., Chen, C., Chen, X., Zhang, F., Ma, L., et al. (2019) · Nature Communications

T-cell and B-cell ImmunologyEpigenetics and DNA Methylation

Cited by 208

Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s disease

Zhang, L., Silva, T. C., Young, J. I., Gomez, L., Schmidt, M. A., Hamilton-Nelson, K. L., Kunkle, B. W., Chen, X., Martin, E. R., & Wang, L. (2020) · Nature Communications

Epigenetics and DNA MethylationDementia and Cognitive Impairment Research

Cited by 139

Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors

Lv, X., Lu, X., Cao, J., Luo, Q., Ding, Y., Peng, F., Pataer, A., Lu, D., Han, D., Malmberg, E., et al. (2023) · Science

Endoplasmic Reticulum Stress and DiseaseProtein Kinase Regulation and GTPase Signaling

Cited by 123

12-h clock regulation of genetic information flow by XBP1s

Pan, Y., Ballance, H., Meng, H., Gonzalez, N., Kim, S.-M., Abdurehman, L., York, B., Chen, X., Schnytzer, Y., Levy, O., et al. (2020) · PLOS Biology

Circadian rhythm and melatoninGenomics and Chromatin Dynamics

Cited by 70

Sex-specific DNA methylation differences in Alzheimer’s disease pathology

Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Acta Neuropathologica Communications

Epigenetics and DNA MethylationAlzheimer's disease research and treatments

Cited by 58

Hippocampal CD39/ENTPD1 promotes mouse depression‐like behavior through hydrolyzing extracellular ATP

Cui, Q., Hu, Z., Hu, Y., Chen, X., Wang, J., Mao, L., Lu, X., Ni, M., Chen, J., & Wang, F. (2020) · The EMBO Reports

Adenosine and Purinergic SignalingTreatment of Major Depression

Cited by 56

Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing

Maneix, L., Iakova, P., Lee, C. G., Moree, S. E., Lu, X., Datar, G. K., Hill, C. T., Spooner, E., King, J. C. K., Sykes, D. B., et al. (2024) · Nature Cell Biology

Heat shock proteins researchSignaling Pathways in Disease

Cited by 28