Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes

The cancer genome atlas pan-cancer analysis project

The Cancer Genome Atlas Research Network, Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Shmulevich, I., Sander, C., & Stuart, J. M. (2013) · Nature Genetics · doi:10.1038/ng.2764 · Cited by 9,092 · see citing works

Cancer Genome Landscapes

Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863 · see citing works

High-Resolution Profiling of Histone Methylations in the Human Genome

Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845 · see citing works

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Lawrence, M. S., Stojanov, P., Polak, P., Kryukov, G. V., Cibulskis, K., Sivachenko, A., Carter, S. L., Stewart, C., Mermel, C. H., Roberts, S. A., et al. (2013) · Nature · doi:10.1038/nature12213 · Cited by 5,461 · see citing works

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.035 · Cited by 4,143 · see citing works

Super-enhancers in the control of cell identity and disease

Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662 · see citing works

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961 · see citing works

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Lin, C. Y., Lovén, J., Rahl, P. B., Paranal, R. M., Burge, C. B., Bradner, J. E., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.08.026 · Cited by 1,498 · see citing works

Modification of Enhancer Chromatin: What, How, and Why?

Calo, E., & Wysocka, J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.038 · Cited by 1,457 · see citing works

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279 · see citing works

Human housekeeping genes, revisited

Eisenberg, E., & Levanon, E. Y. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.05.010 · Cited by 1,249 · see citing works

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

Nie, Z., Hu, G., Wei, G., Cui, K., Yamane, A., Resch, W., Wang, R., Green, D. R., Tessarollo, L., Casellas, R. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.033 · Cited by 1,063 · see citing works

Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer

Wang, Q., Li, W., Zhang, Y., Yuan, X., Xu, K., Yu, J., Chen, Z., Beroukhim, R., Wang, H., Lupien, M., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.056 · Cited by 897 · see citing works

Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factorsPreprint

Wang, J., Zhuang, J., Iyer, S., Lin, X.-Y., Whitfield, T. W., Greven, M. C., Pierce, B. G., Dong, X., Kundaje, A. B., Cheng, Y., et al. (2012) · Genome Research · doi:10.1101/gr.139105.112 · Cited by 820 · see citing works

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome

Davoli, T., Xu, A. W., Mengwasser, K. E., Sack, L. M., Yoon, J. C., Park, P. J., & Elledge, S. J. (2013) · Cell · doi:10.1016/j.cell.2013.10.011 · Cited by 815 · see citing works

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells

Xie, W., Schultz, M. D., Lister, R., Hou, Z., Rajagopal, N., Ray, P. R., Whitaker, J. W., Tian, S., Hawkins, R. D., Leung, D., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.022 · Cited by 721 · see citing works

Chromatin organization is a major influence on regional mutation rates in human cancer cells

Schuster-Böckler, B., & Lehner, B. (2012) · Nature · doi:10.1038/nature11273 · Cited by 657 · see citing works

Flavopiridol Inactivates P-TEFb and Blocks Most RNA Polymerase II Transcription in Vivo

Chao, S., & Price, D. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102306200 · Cited by 623 · see citing works

Whole-Genome Mapping of Histone H3 Lys4 and 27 Trimethylations Reveals Distinct Genomic Compartments in Human Embryonic Stem Cells

Zhao, X. D., Han, X., Chew, J. L., Liu, J., Chiu, K. P., Choo, A. B. H., Orlov, Y. L., Sung, W.-K. K., Shahab, A., Kuznetsov, V. A., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.08.004 · Cited by 616 · see citing works

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

Jonkers, I., Kwak, H., & Lis, J. T. (2014) · eLife · doi:10.7554/elife.02407 · Cited by 581 · see citing works

Recognition of Trimethylated Histone H3 Lysine 4 Facilitates the Recruitment of Transcription Postinitiation Factors and Pre-mRNA Splicing

Sims, R. J., Millhouse, S., Chen, C.-F., Lewis, B. A., Erdjument‐Bromage, H., Tempst, P., Manley, J. L., & Reinberg, D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.010 · Cited by 581 · see citing works

H3K4me3 breadth is linked to cell identity and transcriptional consistency

Benayoun, B. A., Pollina, E. A., Ucar, D., Mahmoudi, S., Karra, K., Wong, E. D., Devarajan, K., Daugherty, A. C., Kundaje, A. B., Mancini, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.027 · Cited by 536 · see citing works

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

Lauberth, S. M., Nakayama, T., Wu, X., Ferris, A. L., Tang, Z., Hughes, S. H., & Roeder, R. G. (2013) · Cell · doi:10.1016/j.cell.2013.01.052 · Cited by 473 · see citing works

Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments

Kheradpour, P., & Kellis, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1249 · Cited by 443 · see citing works

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

Gutiérrez, A., Sanda, T., Grebliunaite, R., Carracedo, A., Salmena, L., Ahn, Y., Dahlberg, S. E., Neuberg, D. S., Moreau, L. A., Winter, S. S., et al. (2009) · Blood · doi:10.1182/blood-2009-02-206722 · Cited by 437 · see citing works

DANPOS: Dynamic analysis of nucleosome position and occupancy by sequencingPreprint

Chen, K.-F., Xi, Y., Pan, X.-W., Li, Z.-Y., Kaestner, K., Tyler, J. K., Dent, S., He, X.-W., & Li, W. (2013) · Genome Research · doi:10.1101/gr.142067.112 · Cited by 415 · see citing works

Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites

Borde, V., Robine, N., Lin, W., Bonfils, S., Géli, V., & Nicolas, A. G. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.257 · Cited by 380 · see citing works

RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes

Glover-Cutter, K. M., Kim, S., Espinosa, J. M., & Bentley, D. L. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1352 · Cited by 343 · see citing works

Large conserved domains of low DNA methylation maintained by Dnmt3a

Jeong, M., Sun, D., Luo, M., Huang, Y., Challen, G. A., Rodriguez, B., Zhang, X., Chavez, L., Wang, H., Hannah, R., et al. (2014) · Nature Genetics · doi:10.1038/ng.2836 · Cited by 324 · see citing works

Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications

Veloso, A., Kirkconnell, K. S., Magnuson, B., Biewen, B., Paulsen, M. T., Wilson, T. E., & Ljungman, M. (2014) · Genome Research · doi:10.1101/gr.171405.113 · Cited by 281 · see citing works

THE ROLE OF THE IKAROS GENE IN LYMPHOCYTE DEVELOPMENT AND HOMEOSTASIS

Georgopoulos, K., Winandy, S., & Avitahl, N. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.155 · Cited by 267 · see citing works

Transcription-associated histone modifications and cryptic transcription

Smolle, M. M., & Workman, J. L. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.08.008 · Cited by 203 · see citing works

Tumor Suppressor Function of the Plasma Glutathione Peroxidase Gpx3 in Colitis-Associated Carcinoma

Barrett, C. W., Wei, N., Chen, X., Smith, J. J., Washington, M. K., Hill, K. E., Coburn, L. A., Peek, R. M., Chaturvedi, R., Wilson, K. T., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-3150 · Cited by 196 · see citing works

Epigenetic Signatures of Autism: Trimethylated H3K4 Landscapes in Prefrontal Neurons

Shulha, H. P. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.151 · Cited by 196 · see citing works

DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes

De, S., & Franziska Michor, A. (2011) · Nature Biotechnology · doi:10.1038/nbt.2030 · Cited by 158 · see citing works

A unique H3K4me2 profile marks tissue-specific gene regulationPreprint

Pękowska, A., Benoukraf, T., Ferrier, P., & Spicuglia, S. (2010) · Genome Research · doi:10.1101/gr.109389.110 · Cited by 149 · see citing works

Histone H3K4me3 Binding Is Required for the DNA Repair and Apoptotic Activities of ING1 Tumor Suppressor

Peña, P. V., Hom, R. A., Hung, T., Lin, H., Kuo, A. J., Wong, R. P. C., Subach, O. M., Champagne, K. S., Zhao, R., Verkhusha, V. V., et al. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.04.061 · Cited by 121 · see citing works

Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia

Virely, C., Moulin, S., Cobaleda, C., Lasgi, C., Alberdi, A., Soulier, J., Sigaux, F., Chan, S. H., Kastner, P., & Ghysdael, J. (2010) · Leukemia · doi:10.1038/leu.2010.63 · Cited by 93 · see citing works

Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer

Chen, Z., Lan, X., Thomas‐Ahner, J. M., Wu, D., Liu, X., Ye, Z., Wang, L., Sunkel, B. D., Grenade, C., Chen, J., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201490306 · Cited by 91 · see citing works

Molecular basis for chromatin binding and regulation of MLL5

Ali, M., Rincón-Arano, H., Zhao, W., Rothbart, S. B., Tong, Q., Parkhurst, S. M., Strahl, B. D., Deng, L.-W., Groudine, M., & Kutateladze, T. G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310156110 · Cited by 84 · see citing works

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events

Mendes, R. D., Sarmento, L. M., Canté-Barrett, K., Zuurbier, L. C., Buijs-Gladdines, J. G. C. A. M., Póvoa, V., Smits, W. K., Abecasis, M., Yunes, J. A., Sonneveld, E., et al. (2014) · Blood · doi:10.1182/blood-2014-03-562751 · Cited by 84 · see citing works

The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth, and chemosensitivity under hypoxic conditions

Matthew, E. M., Hart, L. S., Astrinidis, A., Navaraj, A., Dolloff, N. G., Dicker, D. T., Henske, E. P., & El-Deiry, W. S. (2009) · Cell Cycle · doi:10.4161/cc.8.24.10800 · Cited by 67 · see citing works

Mutant Ikzf1, Kras G12D , and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents

Dail, M., Li, Q., McDaniel, A., Wong, J. W. H., Akagi, K., Huang, B. J., Kang, H. C., Kogan, S. C., Shokat, K. M., Wolff, L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001064107 · Cited by 63 · see citing works

UpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions

Rincón‐Arano, H., Halow, J. M., Delrow, J. J., Parkhurst, S. M., & Groudine, M. T. (2012) · Cell · doi:10.1016/j.cell.2012.11.009 · Cited by 61 · see citing works

Regulation of mitochondrial ATP synthesis in mammalian cells by transcriptional control

Kagawa, Y., & Shigeo, O. (1990) · International Journal of Biochemistry · doi:10.1016/0020-711x(90)90333-x · Cited by 49 · see citing works

Epigenetic Inactivation Implies a Tumor Suppressor Function in Hematologic Malignancies for Polo-Like Kinase 2 but not Polo-Like Kinase 3

Smith, P. J., Syed, N., & Crook, T. (2006) · Cell Cycle · doi:10.4161/cc.5.12.2813 · Cited by 41 · see citing works

Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in cancer

Coley, H. M., Hatzimichael, E. C., Blagden, S. P., McNeish, I. A., Thompson, A., Crook, T., & Syed, N. (2012) · Oncotarget · doi:10.18632/oncotarget.332 · Cited by 32 · see citing works

Histone post-translational modifications - cause and consequence of genome function

Millán-Zambrano, G., Burton, A., Bannister, A. J., & Schneider, R. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00468-7 · Cited by 1,116 · see citing works

Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

Liu, X., Wang, C., Liu, W., Li, J., Li, C., Kou, X., Chen, J., Zhao, Y., Gao, H., Wang, H., et al. (2016) · Nature · doi:10.1038/nature19362 · Cited by 746 · see citing works

The impact of cellular metabolism on chromatin dynamics and epigenetics

Reid, M. A., Dai, Z., & Locasale, J. W. (2017) · Nature Cell Biology · doi:10.1038/ncb3629 · Cited by 515 · see citing works

The Aging Epigenome

Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499 · see citing works

Is H3K4me3 instructive for transcription activation?

Howe, F. S., Fischl, H., Murray, S. C., & Mellor, J. (2016) · BioEssays · doi:10.1002/bies.201600095 · Cited by 515 · see citing works

One‐carbon metabolism and epigenetics: understanding the specificity

Mentch, S. J., & Locasale, J. W. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12956 · Cited by 481 · see citing works

H3K4me3 regulates RNA polymerase II promoter-proximal pause-release

Wang, H., Fan, Z., Shliaha, P. V., Miele, M., Hendrickson, R. C., Jiang, X., & Helin, K. (2023) · Nature · doi:10.1038/s41586-023-05780-8 · Cited by 422 · see citing works

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

Benayoun, B. A., Pollina, E. A., Singh, P. P., Mahmoudi, S., Harel, I., Casey, K. M., Dulken, B. W., Kundaje, A., & Brunet, A. (2019) · Genome Research · doi:10.1101/gr.240093.118 · Cited by 360 · see citing works

Stem cells and healthy aging

Goodell, M. A., & Rando, T. A. (2015) · Science · doi:10.1126/science.aab3388 · Cited by 347 · see citing works

Inhibition of fatty acid oxidation enables heart regeneration in adult mice

Li, X., Wu, F., Günther, S., Looso, M., Kuenne, C. T., Zhang, T., Wiesnet, M., Klatt, S., Zukunft, S., Fleming, I., et al. (2023) · Nature · doi:10.1038/s41586-023-06585-5 · Cited by 266 · see citing works

The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes

Beacon, T. H., Delcuve, G. P., Lopez, C. L., Nardocci, G., Kovalchuk, I., van Wijnen, A. J., & Davie, J. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01126-1 · Cited by 252 · see citing works

Epigenome in Early Mammalian Development: Inheritance, Reprogramming and Establishment

Xu, Q., & Xie, W. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.10.008 · Cited by 214 · see citing works

Determinants of Histone H3K4 Methylation Patterns

Soares, L. M., He, P. C., Chun, Y., Suh, H., Kim, T., & Buratowski, S. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.013 · Cited by 209 · see citing works

Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance

Chen, K., Luan, X., Liu, Q., Wang, J., Chang, X., Snijders, A. M., Mao, J.-H., Secombe, J., Dan, Z., Chen, J.-H., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.02.003 · Cited by 208 · see citing works

LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling

Luo, J., Wang, K., Yeh, S., Sun, Y., Liang, L., Xiao, Y., Xu, W., Niu, Y., Liang Cheng, C., Maity, S. N., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09784-9 · Cited by 205 · see citing works

Histone H3 lysine K4 methylation and its role in learning and memory

Collins, B. E., Greer, C. B., Coleman, B. C., & Sweatt, J. D. (2019) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0251-8 · Cited by 194 · see citing works

Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex

Shen, H., Xu, W., Guo, R., Rong, B., Gu, L., Wang, Z., He, C., Zheng, L., Hu, X., Hu, Z., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.064 · Cited by 184 · see citing works

A compendium and comparative epigenomics analysis of cis-regulatory elements in the pig genome

Zhao, Y.-X., Hou, Y., Xu, Y., Luan, Y., Zhou, H., Qi, X.-L., Hu, M.-Y., Wang, D.-Y., Wang, Z., Fu, Y.-H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22448-x · Cited by 120 · see citing works

Roles of H3K4 methylation in biology and disease

Wang, H., & Helin, K. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.06.001 · Cited by 167 · see citing works

Protein oxidation, UVA and human DNA repair

Karran, P., & Brem, R. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.024 · Cited by 163 · see citing works

5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes

Mellén, M., Ayata, P., & Heintz, N. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708044114 · Cited by 151 · see citing works

Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications

Ebmeier, C. C., Erickson, B., Allen, B. L., Allen, M. A., Kim, H., Fong, N., Jacobsen, J. R., Liang, K., Shilatifard, A., Dowell, R. D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.021 · Cited by 157 · see citing works

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes

Dhar, S. S., Zhao, D., Lin, T., Gu, B., Pal, K., Wu, S. J., Alam, H., Lv, J., Yun, K., Gopalakrishnan, V., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.04.028 · Cited by 145 · see citing works

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width

Dai, Z., Mentch, S. J., Gao, X., Nichenametla, S. N., & Locasale, J. W. (2018) · Nature Communications · doi:10.1038/s41467-018-04426-y · Cited by 132 · see citing works

OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms

Zhang, X., Xiao, X., Lan, P., Li, J., Dou, Y., Chen, W., Ishii, N., Chen, S., Xia, B., Chen, K., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.052 · Cited by 123 · see citing works

Single-molecule nascent RNA sequencing identifies regulatory domain architecture at promoters and enhancers

Tome, J. M., Tippens, N. D., & Lis, J. T. (2018) · Nature Genetics · doi:10.1038/s41588-018-0234-5 · Cited by 112 · see citing works

NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements

Hirabayashi, S., Bhagat, S., Matsuki, Y., Takegami, Y., Uehata, T., Kanemaru, A., Itoh, M., Shirakawa, K., Takaori‐Kondo, A., Takeuchi, O., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0485-9 · Cited by 109 · see citing works

EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape

Liefke, R., Karwacki-Neisius, V., & Shi, Y. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.019 · Cited by 115 · see citing works

Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies

Shah, R. N., Grzybowski, A. T., Cornett, E. M., Johnstone, A. L., Dickson, B. M., Boone, B. A., Cheek, M. A., Cowles, M. W., Maryanski, D. N., Meiners, M. J., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.015 · Cited by 117 · see citing works

H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation

Huang, Y., Gu, L., & Li, G. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002839 · Cited by 102 · see citing works

PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression

Lee, K.-W., Yeo, S.-Y., Gong, J.-R., Koo, O.-J., Sohn, I., Lee, W. Y., Kim, H. C., Yun, S. H., Cho, Y. B., Choi, M.-A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30484-4 · Cited by 103 · see citing works

RPA binds histone H3-H4 and functions in DNA replication–coupled nucleosome assembly

Liu, S., Xu, Z., Leng, H., Zheng, P., Yang, J., Chen, K., Feng, J., & Li, Q. (2017) · Science · doi:10.1126/science.aah4712 · Cited by 108 · see citing works

SEA: a super-enhancer archive

Wei, Y., Zhang, S., Shang, S., Zhang, B., Li, S., Wang, X., Wang, F., Su, J., Wu, Q., Liu, H., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1243 · Cited by 104 · see citing works

Germline Duplication of SNORA18L5 Increases Risk for HBV-related Hepatocellular Carcinoma by Altering Localization of Ribosomal Proteins and Decreasing Levels of p53

Cao, P., Yang, A., Wang, R., Xia, X., Zhai, Y., Li, Y., Yang, F., Cui, Y., Xie, W., Liu, Y., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.04.020 · Cited by 101 · see citing works

Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains

Gopi, L. K., & Kidder, B. L. (2021) · Nature Communications · doi:10.1038/s41467-021-21707-1 · Cited by 95 · see citing works

Integrated multi-omics reveal epigenomic disturbance of assisted reproductive technologies in human offspring

Chen, W., Peng, Y., Ma, X., Kong, S., Tan, S., Wei, Y., Zhao, Y., Zhang, W., Wang, Y., Yan, L., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103076 · Cited by 91 · see citing works

Mediator complex interaction partners organize the transcriptional network that defines neural stem cells

Quevedo, M., Meert, L., Dekker, M. R., Dekkers, D. H. W., Brandsma, J. H., van den Berg, D. L. C., Özgür, Z., van IJcken, W. F. J., Demmers, J., Fornerod, M. W. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10502-8 · Cited by 88 · see citing works

A Role for Chromatin Remodeling in Cohesin Loading onto Chromosomes

Muñoz, S., Minamino, M., Casas-Delucchi, C. S., Patel, H., & Uhlmann, F. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.027 · Cited by 88 · see citing works

The Lysine Methyltransferase G9a in Immune Cell Differentiation and Function

Scheer, S., & Zaph, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00429 · Cited by 84 · see citing works

Broad domains of histone H3 lysine 4 trimethylation in transcriptional regulation and disease

Park, S., Kim, G. W., Kwon, S. H., & Lee, J. (2020) · FEBS Journal · doi:10.1111/febs.15219 · Cited by 83 · see citing works

STARR-seq identifies active, chromatin-masked, and dormant enhancers in pluripotent mouse embryonic stem cells

Peng, T., Zhai, Y., Atlasi, Y., ter Huurne, M., Marks, H., Stunnenberg, H. G., & Megchelenbrink, W. (2020) · Genome Biology · doi:10.1186/s13059-020-02156-3 · Cited by 83 · see citing works

Super-enhancers and broad H3K4me3 domains form complex gene regulatory circuits involving chromatin interactions

Cao, F., Fang, Y., Tan, H. K., Goh, Y., Choy, J. Y. H., Koh, B. T. H., Hao Tan, J., Bertin, N., Ramadass, A., Hunter, E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02257-3 · Cited by 80 · see citing works

Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus1

Beacon, T. H., Delcuve, G. P., & Davie, J. (2020) · Genome · doi:10.1139/gen-2020-0124 · Cited by 75 · see citing works

OCEAN-C: mapping hubs of open chromatin interactions across the genome reveals gene regulatory networks

Li, T., Jia, L., Cao, Y., Chen, Q., & Li, C. (2018) · Genome biology · doi:10.1186/s13059-018-1430-4 · Cited by 77 · see citing works

Neural Stimulation and Molecular Mechanisms of Plasticity and Regeneration: A Review

Hogan, M., Hamilton, G. F., & Horner, P. J. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00271 · Cited by 74 · see citing works

Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors

Dhar, S. S., & Lee, M. G. (2021) · Oncotarget · doi:10.18632/oncotarget.27988 · Cited by 70 · see citing works

Efficient chromatin profiling of H3K4me3 modification in cotton using CUT&Tag

Tao, X., Feng, S., Zhao, T., & Guan, X. (2020) · Plant Methods · doi:10.1186/s13007-020-00664-8 · Cited by 71 · see citing works

Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin

Schwartz, U., Németh, A., Diermeier, S., Exler, J. H., Hansch, S., Maldonado, R., Heizinger, L., Merkl, R., & Längst, G. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1203 · Cited by 64 · see citing works

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

Park, S. H., Ayoub, A. M., Lee, Y., Xu, J., Kim, H., Zheng, W. H., Zhang, B., Liang, S., An, S., Zhang, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13550-2 · Cited by 68 · see citing works

Coordinated regulation of cellular identity–associated H3K4me3 breadth by the COMPASS family

Sze, C. C., Ozark, P. A., Cao, K., Ugarenko, M., Das, S., Wang, L., Marshall, S. A., Rendleman, E. J., Ryan, C., Zha, D., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz4764 · Cited by 66 · see citing works

Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC

Li, J., Wu, X.-W., Zhou, Y.-B., Lee, M., Guo, L., Han, W., Mo, W., Cao, W., Sun, D.-Q., Xie, R., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky063 · Cited by 67 · see citing works

Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases

Cildir, G., Toubia, J., Yip, K. H., Zhou, M., Pant, H., Hissaria, P., Zhang, J., Hong, W., Robinson, N., Grimbaldeston, M. A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.021 · Cited by 65 · see citing works

Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function

Russ, B. E., Olshansky, M., Li, J., Nguyen, M. L. T., Gearing, L. J., Nguyen, T. H. O., Olson, M. R., McQuilton, H. A., Nüssing, S., Khoury, G., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.097 · Cited by 65 · see citing works

Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation

Cheng, H., Xuan, H., Green, C. D., Han, Y., Sun, N., Shen, H., McDermott, J., Bennett, D. A., Lan, F., & Han, J. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800656115 · Cited by 64 · see citing works

Lineage specification and pluripotency revealed by transcriptome analysis from oocyte to blastocyst in pig

Kong, Q., Xu, Y., Zhang, H., Liu, S., Zhao, J., Zhang, J., Weng, X., Jin, J., & Liu, Z. (2019) · The FASEB Journal · doi:10.1096/fj.201901818rr · Cited by 65 · see citing works

DORGE: Discovery of Oncogenes and tumoR suppressor genes using Genetic and Epigenetic features

Lyu, J., Li, J. J., Su, J., Peng, F., Chen, Y. E., Ge, X., & Li, W. (2020) · Science Advances · doi:10.1126/sciadv.aba6784 · Cited by 60 · see citing works

Targeting Super-Enhancers as a Therapeutic Strategy for Cancer Treatment

He, Y., Long, W., & Liu, Q. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00361 · Cited by 63 · see citing works

Epigenetic gene regulation by histone demethylases: emerging role in oncogenesis and inflammation

Kang, M., Mehrazarin, S., Park, N., & Wang, C. (2016) · Oral Diseases · doi:10.1111/odi.12569 · Cited by 61 · see citing works

Environmental toxicants, incidence of degenerative diseases, and therapies from the epigenetic point of view

Hodjat, M., Rahmani, S., Khan, F., Niaz, K., Nigjeh, M. N., Nejad, S. M., & Abdollahi, M. R. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-1979-9 · Cited by 60 · see citing works

A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing

Tettey, T. T., Gao, X., Shao, W., Li, H., Story, B. A., Chitsazan, A., Glaser, R. L., Goode, Z. H., Seidel, C. W., Conaway, R. C., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.099 · Cited by 59 · see citing works

ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription

Esnault, C., Gualdrini, F., Horswell, S. D., Kelly, G. P., Stewart, A., East, P., Matthews, N., & Treisman, R. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.005 · Cited by 55 · see citing works

Histone lysine demethylases in mammalian embryonic development

Shen, H., Xu, W., & Lan, F. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.57 · Cited by 58 · see citing works

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

Mallm, J., Iskar, M., Ishaque, N., Klett, L. C., Kugler, S. J., Muiño, J. M., Teif, V. B., Poos, A. M., Großmann, S., Erdel, F., et al. (2019) · Molecular Systems Biology · doi:10.15252/msb.20188339 · Cited by 55 · see citing works

Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16

Shimoda, H., Doi, S., Nakashima, A., Sasaki, K., Doi, T., & Masaki, T. (2019) · Kidney International · doi:10.1016/j.kint.2019.06.021 · Cited by 54 · see citing works

SET/MLL family proteins in hematopoiesis and leukemia

Yang, W., & Ernst, P. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-2118-8 · Cited by 53 · see citing works

RNF40 regulates gene expression in an epigenetic context-dependent manner

Xie, W., Nagarajan, S., Baumgart, S. J., Kosinsky, R. L., Najafova, Z., Kari, V., Hennion, M., Indenbirken, D., Bonn, S., Grundhoff, A. T., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1159-5 · Cited by 55 · see citing works

H3K4 demethylase KDM5B regulates global dynamics of transcription elongation and alternative splicing in embryonic stem cells

He, R., & Kidder, B. L. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx251 · Cited by 54 · see citing works

TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains

Guerrero-Martínez, J. A., Ceballos-Chávez, M., Koehler, F., Peiró, S., & Reyes, J. (2020) · Nature Communications · doi:10.1038/s41467-020-19877-5 · Cited by 44 · see citing works

Targeting ROS-sensing Nrf2 potentiates anti-tumor immunity of intratumoral CD8+ T and CAR-T cells

Jo, Y., Shim, J. A., Jeong, J. W., Kim, H., Lee, S. M., Jeong, J., Kim, S., Im, S., Choi, D., Lee, B. H., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.08.019 · Cited by 53 · see citing works

NSD1 Inactivation and SETD2 Mutation Drive a Convergence toward Loss of Function of H3K36 Writers in Clear Cell Renal Cell Carcinomas

Su, X., Zhang, J., Mouawad, R., Compérat, É., Morgan Rouprêt, A., Allanic, F., Parra, J., Bitker, M., Thompson, E. J., Gowrishankar, B., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0143 · Cited by 53 · see citing works

Super-enhancers are transcriptionally more active and cell type-specific than stretch enhancers

Khan, A., Mathelier, A., & Zhang, X. (2018) · Epigenetics · doi:10.1080/15592294.2018.1514231 · Cited by 56 · see citing works

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

Barišić, D., Chin, C. R., Meydan, C., Teater, M. R., Tsialta, I., Mlynarczyk, C., Chadburn, A., Wang, X., Sarkozy, M., Xia, M., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.02.010 · Cited by 52 · see citing works

CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release

Velychko, T., Mohammad, E., Vicens, I. F., Parfentev, I., Werner, M., Studniarek, C., Schwalb, B., Urlaub, H., Murphy, S., Cramer, P., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.05.007 · Cited by 52 · see citing works

Chromatin interaction networks revealed unique connectivity patterns of broad H3K4me3 domains and super enhancers in 3D chromatin

Thibodeau, A., Márquez, E. J., Shin, D., Vera‐Licona, P., & Ucar, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-14389-7 · Cited by 52 · see citing works

Why are so many MLL lysine methyltransferases required for normal mammalian development?

Crump, N. T., & Milne, T. A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03143-z · Cited by 52 · see citing works

Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis

Bobowski, M., Boulet, C., Zummo, F. P., Dubois‐Chevalier, J., Gheeraert, C., Saleh, M. B., Strub, J., Farce, A., Ploton, M., Guille, L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33063-9 · Cited by 47 · see citing works

WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage

Neilsen, B. K., Chakraborty, B., McCall, J. L., Frodyma, D. E., Sleightholm, R. L., Fisher, K. W., & Lewis, R. E. (2018) · BMC Cancer · doi:10.1186/s12885-018-4580-6 · Cited by 51 · see citing works

Distinct chromatin signatures in the Arabidopsis male gametophyte

Zhu, D., Wen, Y., Yao, W., Zheng, H., Zhou, S., Zhang, Q., Qu, L., Chen, X. X., & Wu, Z. (2023) · Nature Genetics · doi:10.1038/s41588-023-01329-7 · Cited by 50 · see citing works

Epigenetic landscape reveals MECOM as an endothelial lineage regulator

Lv, J., Meng, S., Gu, Q., Zheng, R., Gao, X., Kim, J., Chen, M., Xia, B., Zuo, Y.-H., Zhu, S. L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38002-w · Cited by 43 · see citing works

Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver

Dubois, V., Gheeraert, C., Vankrunkelsven, W., Dubois‐Chevalier, J., Dehondt, H., Bobowski‐Gerard, M., Vinod, M., Zummo, F. P., Güiza, F., Ploton, M., et al. (2020) · Molecular Systems Biology · doi:10.15252/msb.20199156 · Cited by 46 · see citing works

Unique patterns of trimethylation of histone H3 lysine 4 are prone to changes during aging in Caenorhabditis elegans somatic cells

Pu, M., Wang, M., Wang, W., Santhi, V. S., & Lee, S. S. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007466 · Cited by 45 · see citing works

Machine learning uncovers cell identity regulator by histone code

Xia, B., Zhao, D., Wang, G., Zhang, M., Lv, J., Tomoiaga, A. S., Li, Y., Wang, X., Meng, S., Cooke, J. P., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16539-4 · Cited by 42 · see citing works

H3K4 trimethylation dynamics impact diverse developmental and environmental responses in plants

Foroozani, M., Vandal, M. P., & Smith, A. P. (2021) · Planta · doi:10.1007/s00425-020-03520-0 · Cited by 43 · see citing works

Low RNA stability signifies increased post-transcriptional regulation of cell identity genes

Li, Y., Yang, Y., Lv, J., Gao, X., Yu, Y., Babu, S. S., Bruno, I., Zhao, D., Xia, B., Peng, W., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad300 · Cited by 43 · see citing works

In vivo dissection of chamber selective enhancers reveals estrogen-related receptor as a regulator of ventricular cardiomyocyte identity

Cao, Y.-P., Zhang, X.-R., Akerberg, B. N., Yuan, H., Sakamoto, T., Xiao, F., VanDusen, N. J., Zhou, P., Sweat, M., Wang, Y., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.061955 · Cited by 35 · see citing works

Aberrant activation of CYR61 enhancers in colorectal cancer development

Xie, L., Song, X., Lin, H. R., Chen, Z., Li, Q., Guo, T., Xu, T., Su, T., Xu, M., Chang, X., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1217-9 · Cited by 42 · see citing works

Distinct functions of histone H3, lysine 4 methyltransferases in normal and malignant hematopoiesis

Yang, W., & Ernst, P. (2017) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000346 · Cited by 40 · see citing works

Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation

Collins, B. E., Sweatt, J. D., & Greer, C. B. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.04.009 · Cited by 39 · see citing works

Distinct epigenomic patterns are associated with haploinsufficiency and predict risk genes of developmental disorders

Han, X., Chen, S., Flynn, E. D., Wu, S., Wintner, D., & Shen, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-04552-7 · Cited by 38 · see citing works

The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions

Murawska, M., Schauer, T., Matsuda, A., Wilson, M. D., Pysik, T., Wojcik, F., Muir, T. W., Hiraoka, Y., Straub, T., & Ladurner, A. G. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.11.016 · Cited by 40 · see citing works

Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High-Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation

Kusuyama, J., Makarewicz, N., Albertson, B. G., Alves-Wagner, A. B., Conlin, R. H., Prince, N. B., Alves, C. R. R., Ramachandran, K., Kozuka, C., Yang, X., et al. (2022) · Diabetes · doi:10.2337/db21-0706 · Cited by 37 · see citing works

Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domainsPreprint

Zhao, Y.-T., Kwon, D. Y., Johnson, B. S., Fasolino, M., Lamonica, J. M., Kim, Y. J., Zhao, B. S., He, C., Vahedi, G., Kim, T. H., et al. (2018) · Genome Research · doi:10.1101/gr.233775.117 · Cited by 35 · see citing works

Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networksPreprint

Li, J., Li, Y., Li, W., Luo, H.-B., Xi, Y.-P., Dong, S.-H., Gao, M., Xu, P., Zhang, B.-L., Liang, Y., et al. (2019) · Genome Research · doi:10.1101/gr.240606.118 · Cited by 33 · see citing works

CRlncRC: a machine learning-based method for cancer-related long noncoding RNA identification using integrated features

Zhang, X., Wang, J., Li, J., Chen, W., & Liu, C. (2018) · BMC Medical Genomics · doi:10.1186/s12920-018-0436-9 · Cited by 34 · see citing works

Unique Patterns of H3K4me3 and H3K27me3 in 2-Cell-like Embryonic Stem Cells

Zhang, Y., Huang, Y., Dong, Y., Liu, X., Kou, X., Zhao, Y., Zhao, A., Sun, J., Su, Z., Li, Z., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.01.020 · Cited by 32 · see citing works

Stable H3K4me3 is associated with transcription initiation during early embryo development

Huang, X., Gao, X., Li, W., Jiang, S., Li, R., Hong, H., Zhao, C., Zhou, P., Chen, H., Bo, X., et al. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz173 · Cited by 31 · see citing works

H3K4 Methylation in Aging and Metabolism

Hsu, C.-L., Lo, Y., & Kao, C.-F. (2021) · Epigenomes · doi:10.3390/epigenomes5020014 · Cited by 30 · see citing works

Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos

Bai, D., Sun, J., Chen, C., Jia, Y., Li, Y., Liu, K., Zhang, Y., Yin, J., Liu, Y., Han, X., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110784 · Cited by 31 · see citing works

An overview of artificial intelligence in the field of genomics

Maqsood, K., Hagras, H., & Zabet, N. R. (2024) · Discover Artificial Intelligence · doi:10.1007/s44163-024-00103-w · Cited by 34 · see citing works

Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia

Boudreaux, S. P., Duren, R. P., Call, S. G., Nguyen, L., Freire, P. R., Narayanan, P., Redell, M. S., & Conneely, O. M. (2018) · Leukemia · doi:10.1038/s41375-018-0174-1 · Cited by 30 · see citing works

A Broad H3K4me3 Signature Enriches for Tumor-Suppressor Genes

(2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2015-166

Broad H3K4me3 domains: Maintaining cellular identity and their implication in super‐enhancer hijacking

Kent, D., Marchetti, L., Mikulášová, A., Russell, L. J., & Rico, D. (2023) · BioEssays · doi:10.1002/bies.202200239 · Cited by 27 · see citing works

Differential H3K4me3 Domains in Normal and Colorectal Cancer Cells Reveal Novel Epigenetic Targets

Bahia, R. K., Lopez, C. L., Nardocci, G., & Davie, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062546 · Cited by 2 · see citing works

The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes

Beacon, T. H., Delcuve, G. P., Lopez, C. L., Nardocci, G., Kovalchuk, I., van Wijnen, A. J., & Davie, J. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01126-1 · Cited by 252 · see citing works

The key role of differential broad H3K4me3 and H3K4ac domains in breast cancer

Lopez, C. L., Barnon, M. T., Beacon, T. H., Nardocci, G., & Davie, J. (2022) · Gene · doi:10.1016/j.gene.2022.146463 · Cited by 19 · see citing works