Singleton, Andrew B.

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

Bras, J., Guerreiro, R., Darwent, L., Parkkinen, L., Ansorge, O., Escott-Price, V., Hernandez, D. G., Nalls, M. A., Clark, L. N., Honig, L. S., et al. (2014) · Human Molecular Genetics

Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

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Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

Tanaka, T., Ngwa, J. S., van Rooij, F. J., Zillikens, M. C., Wojczynski, M. K., Frazier-Wood, A. C., Houston, D. K., Kanoni, S., Lemaitre, R. N., Luan, J., et al. (2013) · The American Journal of Clinical Nutrition

Nutrition, Genetics, and DiseaseGenetic Associations and Epidemiology

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Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study

Nalls, M. A., McLean, C. Y., Rick, J., Eberly, S., Hutten, S. J., Gwinn, K., Sutherland, M., Martinez, M., Heutink, P., Williams, N. M., et al. (2015) · The Lancet Neurology

Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

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Using genome-wide complex trait analysis to quantify ‘missing heritability’ in Parkinson’s disease

Keller, M. F., Saad, M., Bras, J., Bettella, F., Nicolaou, N., Simon-Sanchez, J., Mittag, F., Buchel, F., Sharma, M., Gibbs, J. R., et al. (2012) · Human Molecular Genetics

Genetic Associations and EpidemiologyParkinson's Disease Mechanisms and Treatments

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A Genome-Wide Association Study of Depressive Symptoms

Hek, K., Demirkan, A., Lahti, J., Terracciano, A., Teumer, A., Cornelis, M. C., Amin, N., Bakshis, E., Baumert, J., Ding, J., et al. (2013) · Biological Psychiatry

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

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A Common Variation in Deiodinase 1 Gene DIO1 Is Associated with the Relative Levels of Free Thyroxine and Triiodothyronine

Panicker, V., Cluett, C., Shields, B., Murray, A., Parnell, K. S., Perry, J. R. B., Weedon, M. N., Singleton, A., Hernandez, D., Evans, J., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsGenetic Associations and Epidemiology

Cited by 155

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

Rusu, V., Hoch, E., Mercader, J. M., Tenen, D. E., Gymrek, M., Hartigan, C. R., DeRan, M., von Grotthuss, M., Fontanillas, P., Spooner, A., et al. (2017) · Cell

Genetic Associations and EpidemiologyMetabolism, Diabetes, and Cancer

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Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Swarup, V., Hinz, F. I., Rexach, J. E., Noguchi, K.-I., Toyoshiba, H., Oda, A., Hirai, K., Sarkar, A., Seyfried, N. T., Cheng, C., et al. (2019) · Nature Medicine

Alzheimer's disease research and treatmentsBioinformatics and Genomic Networks

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Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation

Guo, L., Bertola, D. R., Takanohashi, A., Saito, A., Segawa, Y., Yokota, T., Ishibashi, S., Nishida, Y., Yamamoto, G. L., Franco, J. F. D. S., et al. (2019) · The American Journal of Human Genetics

Bone Metabolism and DiseasesConnective tissue disorders research

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Comparing Spatial Maps of Human Population-Genetic Variation Using Procrustes Analysis

Wang, C., Szpiech, Z. A., Degnan, J. H., Jakobsson, M., Pemberton, T. J., Hardy, J. A., Singleton, A. B., & Rosenberg, N. A. (2010) · Statistical Applications in Genetics and Molecular Biology

Forensic and Genetic ResearchGenetic diversity and population structure

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Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease

Guerreiro, R. J., Lohmann, E., Kinsella, E., Brás, J. M., Luu, N., Gurunlian, N., Dursun, B., Bilgic, B., Santana, I., Hanagasi, H., et al. (2012) · Neurobiology of Aging

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Association of a common genetic variant with Parkinson’s disease is mediated by microglia

Langston, R. G., Beilina, A., Reed, X., Kaganovich, A., Singleton, A. B., Blauwendraat, C., Gibbs, J. R., & Cookson, M. R. (2022) · Science Translational Medicine

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

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The Parkinson's Disease Genome‐Wide Association Study Locus Browser

Grenn, F. P., Kim, J. J., Makarious, M. B., Iwaki, H., Illarionova, A., Brolin, K., Kluss, J. H., Schumacher‐Schuh, A. F., Leonard, H., Faghri, F., et al. (2020) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsGenetic Associations and Epidemiology

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The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease

Bandres‐Ciga, S., Saez‐Atienzar, S., Bonet‐Ponce, L., Billingsley, K., Vitale, D., Blauwendraat, C., Gibbs, J. R., Pihlstrøm, L., Gan‐Or, Z., The International Parkinson's Disease Genomics Consortium (IPDGC), et al. (2019) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsGenetic Associations and Epidemiology

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Effect of Complement CR1 on Brain Amyloid Burden During Aging and Its Modification by APOE Genotype

Thambisetty, M., An, Y., Nalls, M., Sojkova, J., Swaminathan, S., Zhou, Y., Singleton, A. B., Wong, D. F., Ferrucci, L., Saykin, A. J., et al. (2013) · Biological Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p

Pearson, J. P., Williams, N. M., Majounie, E., Waite, A., Stott, J., Newsway, V., Murray, A., Hernandez, D., Guerreiro, R., Singleton, A. B., et al. (2011) · Journal of Neurology

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Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

Initiative, F. T. A. D. N., Ridge, P. G., Karch, C. M., Hsu, S., Arano, I., Teerlink, C. C., Ebbert, M. T. W., Gonzalez Murcia, J. D., Farnham, J. M., Damato, A. R., et al. (2017) · Genome Medicine

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LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

Kim, C., Beilina, A., Smith, N., Li, Y., Kim, M., Kumaran, R., Kaganovich, A., Mamais, A., Adame, A., Iba, M., et al. (2020) · Science Translational Medicine

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

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A proteogenomic view of Parkinson’s disease causality and heterogeneity

Kaiser, S., Zhang, L., Mollenhauer, B., Jacob, J., Longerich, S., Del-Aguila, J., Marcus, J., Raghavan, N., Stone, D., Fagboyegun, O., et al. (2023) · npj Parkinson's Disease

Parkinson's Disease Mechanisms and TreatmentsAdvanced Proteomics Techniques and Applications

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Additional rare variant analysis in Parkinson’s disease cases with and without known pathogenic mutations: Evidence for oligogenic inheritance

Lubbe, S. J., Escott-Price, V., Gibbs, J. R., Nalls, M. A., Bras, J., Price, T. R., Nicolas, A., Jansen, I. E., Mok, K. Y., Pittman, A. M., et al. (2016) · Human Molecular Genetics

Parkinson's Disease Mechanisms and TreatmentsLysosomal Storage Disorders Research

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Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositis

Gang, Q., Bettencourt, C., Machado, P. M., Brady, S., Holton, J. L., Pittman, A. M., Hughes, D., Healy, E., Parton, M., Hilton-Jones, D., et al. (2016) · Neurobiology of Aging

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Initial Assessment of the Pathogenic Mechanisms of the Recently Identified Alzheimer Risk Loci

Holton, P., Ryten, M., Nalls, M., Trabzuni, D., Weale, M. E., Hernandez, D., Crehan, H., Gibbs, J. R., Mayeux, R., Haines, J. L., et al. (2013) · Annals of Human Genetics

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Pathology of early-onset Alzheimer's disease cases bearing the Thr113-114ins presenilin-1 mutation

Singleton, A. B. (2000) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Artificial intelligence for dementia genetics and omics

Bettencourt, C., Skene, N., Bandres‐Ciga, S., Anderson, E., Winchester, L. M., Foote, I. F., Schwartzentruber, J., Botia, J. A., Nalls, M., Singleton, A., et al. (2023) · Alzheimer's & Dementia

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