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Sosero, Y. L., & Gan‐Or, Z. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51776 · Cited by 99 · see citing works

Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions

Noh, M., Kwon, H. S., Kwon, M., Nahm, M., Jin, H. K., Bae, J., & Kim, S. H. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00867-4 · Cited by 85 · see citing works

LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition

Yadavalli, N., & Ferguson, S. M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2303789120 · Cited by 75 · see citing works

Neurodegeneration cell per cell

Balusu, S., Praschberger, R., Lauwers, E., Strooper, B. D., & Verstreken, P. (2023) · Neuron · doi:10.1016/j.neuron.2023.01.016 · Cited by 51 · see citing works

Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy

Choi, I., Heaton, G. R., Lee, Y.-K., & Yue, Z. (2022) · Science Advances · doi:10.1126/sciadv.abn1298 · Cited by 53 · see citing works

Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10

Wang, X., Negrou, E., Maloney, M. T., Bondar, V. V., Andrews, S. V., Montalban, M., Llapashtica, C., Maciuca, R. D., Nguyen, H. N., Solanoy, H. O., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91943-4 · Cited by 50 · see citing works

New insight on microglia activation in neurodegenerative diseases and therapeutics

Xu, Y., Gao, W., Sun, Y., & Wu, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1308345 · Cited by 49 · see citing works

Multi-omic insights into Parkinson's Disease: From genetic associations to functional mechanisms

Schilder, B. M., Navarro, E., & Raj, T. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105580 · Cited by 42 · see citing works

LRRK2 in Parkinson's disease: upstream regulation and therapeutic targeting

Xiong, Y., & Yu, J. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.07.003 · Cited by 44 · see citing works

Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Molecular Brain · doi:10.1186/s13041-024-01128-z · Cited by 38 · see citing works

New therapies on the horizon: Targeted protein degradation in neuroscience

Gregory, J. A., Hickey, C. M., Chavez, J. D., & Cacace, A. M. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.08.010 · Cited by 39 · see citing works

Tools for studying human microglia: In vitro and in vivo strategies

Warden, A. S., Han, C. Z., Hansen, E. A., Trescott, S., Nguyen, C. T., Kim, R. Y., Schafer, D. M., Johnson, A., Wright, M., Ramírez, G., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.10.008 · Cited by 36 · see citing works

Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk

Lake, J., Reed, X., Langston, R. G., Nalls, M. A., Gan‐Or, Z., Cookson, M., Singleton, A., Blauwendraat, C., & Leonard, H. L. (2021) · Movement Disorders · doi:10.1002/mds.28787 · Cited by 37 · see citing works

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

Humphrey, J., Brophy, E., Kosoy, R., Zeng, B., Coccia, E., Mattei, D., Ravi, A., Naito, T., Efthymiou, A. G., Navarro, E., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02099-0 · Cited by 36 · see citing works

Redefining the hypotheses driving Parkinson’s diseases research

Farrow, S. L., Cooper, A. A., & O'Sullivan, J. M. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00307-w · Cited by 33 · see citing works

Pressure sensing of lysosomes enables control of TFEB responses in macrophages

Cai, R., Scott, O., Ye, G., Le, T., Saran, E., Kwon, W., Inpanathan, S., Sayed, B. A., Botelho, R. J., Sarić, A., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01459-y · Cited by 32 · see citing works

The emerging neuroimmune hypothesis of bipolar disorder: An updated overview of neuroimmune and microglial findings

Filho, A. J. M. C., Eyres, C., Blöbaum, L., Landwehr, A., & Tremblay, M. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16098 · Cited by 30 · see citing works

Microglia: roles and genetic risk in Parkinson’s disease

Trainor, A. R., MacDonald, D. S., & Penney, J. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1506358 · Cited by 33 · see citing works

Genetic insights into immune mechanisms of Alzheimer’s and Parkinson’s disease

Nott, A., & Holtman, I. R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1168539 · Cited by 31 · see citing works

LRRK2, lysosome damage, and Parkinson's disease

Bentley‐DeSousa, A., Clegg, D., & Ferguson, S. M. (2025) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2025.102482 · Cited by 29 · see citing works

The emerging role of LRRK2 in tauopathies

Herbst, S., Lewis, P. A., & Morris, H. R. (2022) · Clinical Science · doi:10.1042/cs20220067 · Cited by 23 · see citing works

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis

Bogacki, E. C., Parfitt, G. M., Cunha, A., Longmore, G., Wray, S., Lewis, P. A., & Herbst, S. (2025) · Science Advances · doi:10.1126/sciadv.adv1434 · Cited by 24 · see citing works

The Role of LRRK2 in Intracellular Organelle Dynamics

Boecker, C. A. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.167998 · Cited by 23 · see citing works

Region-specific transcriptional signatures of brain aging in the absence of neuropathology at the single-cell level

Mesecar, M. E., Duffy, M. F., Acri, D. J., Ding, J., Langston, R. G., Shah, S. I., Nalls, M. A., Reed, X., Scholz, S. W., Whitaker, D. T., et al. (2026) · npj Aging · doi:10.1038/s41514-026-00391-9 · Cited by 26 · see citing works

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation

Yuan, Y., Li, H., Sreeram, K., Malankhanova, T. B., Boddu, R., Strader, S., Chang, A., Bryant, N., Yacoubian, T. A., Standaert, D. G., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00738-4 · Cited by 23 · see citing works

LRRK2 signaling in neurodegeneration: two decades of progress

Iannotta, L., & Greggio, E. (2021) · Essays in Biochemistry · doi:10.1042/ebc20210013 · Cited by 21 · see citing works

Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function

Ohtonen, S., Giudice, L., Jäntti, H., Fazaludeen, M. F., Shakirzyanova, A., Gómez‐Budia, M., Välimäki, N., Niskanen, J., Korvenlaita, N., Fagerlund, I., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-49294-9 · Cited by 21 · see citing works

Defining Specific Cell States of MPTP-Induced Parkinson’s Disease by Single-Nucleus RNA Sequencing

Guo, Y., Ma, J., Huang, H., Xu, J., Jiang, C., Ye, K., Chang, N. L., Ge, Q., Wang, G., & Zhao, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810774 · Cited by 18 · see citing works

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

Phillips, B., Western, D., Wang, L., Timsina, J., Sun, Y.-C., Gorijala, P., Yang, C., Do, A. N., Nykänen, N.-P., Álvarez, I., et al. (2023) · npj Parkinson s Disease · doi:10.1038/s41531-023-00555-4 · Cited by 20 · see citing works

Cannabinoid CB2 receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission

Xu, K., Liu, X., Zeng, Q., Liu, Y., Shan, L., Ji, L., Wu, Y., Wu, J., Chen, Y., Li, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115559 · Cited by 18 · see citing works

Epigenome-wide association study of peripheral immune cell populations in Parkinson’s disease

Andersen, M. S., Leikfoss, I. S., Brorson, I. S., Cappelletti, C., Bettencourt, C., Toft, M., & Pihlstrøm, L. (2023) · npj Parkinson s Disease · doi:10.1038/s41531-023-00594-x · Cited by 18 · see citing works

LRRK2 kinase activity regulates Parkinson’s disease-relevant lipids at the lysosome

Maloney, M. T., Wang, X., Ghosh, R., Andrews, S. V., Maciuca, R. D., Masoud, S. T., Agam, M. R., Caprioli, R. M., Astarita, G., Bondar, V. V., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00880-7 · Cited by 18 · see citing works

A leucine‐rich repeat kinase 2 ( LRRK2 ) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls

Vissers, M. F. J. M., Troyer, M. D., Thijssen, E., Pereira, D. R., Heuberger, J. A. A. C., Groeneveld, G. J., & Huntwork, S. (2023) · Clinical and Translational Science · doi:10.1111/cts.13541 · Cited by 15 · see citing works

How Parkinson’s Disease-Linked LRRK2 Mutations Affect Different CNS Cell Types

Bailey, H. M., & Cookson, M. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-230432 · Cited by 15 · see citing works

Parkinson’s disease risk enhancers in microglia

Booms, A., Pierce, S. E., der Schans, E. J. C. V., & Coetzee, G. A. (2024) · iScience · doi:10.1016/j.isci.2024.108921 · Cited by 14 · see citing works

Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?

Iseki, T., Imai, Y., & Hattori, N. (2023) · Biomolecules · doi:10.3390/biom13010178 · Cited by 14 · see citing works

The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease

Strader, S., & West, A. B. (2023) · Biochemical Society Transactions · doi:10.1042/bst20201091 · Cited by 13 · see citing works

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Lang, A. E., Hauser, R. A., Kalia, L. V., Hersh, B. P., Berger, Z., Arenas, R. L., Paisán‐Ruiz, C., Fraser, K. B., Jennings, D. L., Kluss, J. H., et al. (2025) · Movement Disorders · doi:10.1002/mds.70100 · Cited by 11 · see citing works

CRISPRi: a way to integrate iPSC-derived neuronal models

Franks, S. N. J., Heon‐Roberts, R., & Ryan, B. J. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230190 · Cited by 10 · see citing works

Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2

Nazish, I., Mamais, A., Mallach, A., Bettencourt, C., Kaganovich, A., Warner, T. T., Hardy, J., Lewis, P. A., Pocock, J. M., Cookson, M., et al. (2023) · Cells · doi:10.3390/cells13010053 · Cited by 9 · see citing works

Emerging Models to Study Human Microglia In vitro

Jäntti, H., Kistemaker, L., Buonfiglioli, A., de Witte, L. D., Malm, T., & Hol, E. M. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_30 · Cited by 8 · see citing works

Genome‐wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease

Hou, X., Heckman, M. G., Fiesel, F. C., Koga, S., Soto‐Beasley, A. I., Watzlawik, J. O., Zhao, J., Valentino, R. R., Johnson, P. W., White, L. J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70198 · Cited by 9 · see citing works

Efficacy of a benzothiazole‐based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis

Benítez‐Fernández, R., Josa‐Prado, F., Sánchez-Jiménez, E., Laó, Y., García‐Rubia, A., Cumella, J., Martı́nez, A., Palomo, V., & de Castro, F. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14552 · Cited by 9 · see citing works

Insights into Neurodegeneration in Parkinson's Disease from Single‐Cell and Spatial Genomics

Kamath, T., & Macosko, E. Z. (2023) · Movement Disorders · doi:10.1002/mds.29374 · Cited by 7 · see citing works

The human microglia responsome: a resource for microglia states in health and disease

Snijders, G. J. L., Lopes, K. D. P., Sneeboer, M. A. M., Muller, B. Z., Gigase, F. A. J., D’Urso, D., Vialle, R. A., Missall, R. D., Kübler, R., Raj, T., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106095 · Cited by 9 · see citing works

iSCORE-PD: an isogenic stem cell collection to research Parkinson’s disease

Busquets, O., Li, H., Syed, K. M., Jerez, P. Á., Dunnack, J., Bu, R. L., Verma, Y., Pangilinan, G. R., Martin, A., Straub, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74355-8 · Cited by 8 · see citing works

Glial Cells and Itch: Possible Targets for Novel Antipruritic Therapies

Gao, X., Wang, Z., & Du, L. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00638 · Cited by 7 · see citing works

A conserved cell-type gradient across the human mediodorsal and paraventricular thalamusPreprint

Schulmann, A., Feng, N., Auluck, P. K., Mukherjee, A., Komal, R., Leng, Y., Gao, C., Williams, S. K., Roy, S., Usdin, T. B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.03.611112 · Cited by 7 · see citing works

Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types

Holtman, I. R., Glass, C. K., & Nott, A. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_29 · Cited by 6 · see citing works

LRRK2 G2019S variant is associated with transcriptional changes in Parkinson’s disease human myeloid cells under proinflammatory environment

Navarro, E., Efthymiou, A. G., Mattei, D., Parks, M., Riboldi, G. M., Vialle, R. A., Udine, E., Muller, B. Z., Humphrey, J., Allan, A., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03967-0 · Cited by 6 · see citing works

Mechanisms of lysosomal tubulation and sorting driven by LRRK2

Bonet‐Ponce, L., Kluss, J. H., & Cookson, M. (2024) · Biochemical Society Transactions · doi:10.1042/bst20240087 · Cited by 5 · see citing works

Predictive Analysis of Yi-Gai-San's Multifaceted Mechanisms for Tremor-dominant Parkinson's Disease via Network Pharmacology and Molecular Docking Validation

Lin, C., Wu, L., & Tsai, F. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673291838240311075415 · Cited by 5 · see citing works

Genome-wide association study identifies APOE and ZMIZ1 variants as mitophagy modifiers in Lewy body diseasePreprint

Hou, X., Heckman, M. G., Fiesel, F. C., Koga, S., Soto‐Beasley, A. I., Watzlawik, J. O., Zhao, J., Valentino, R. R., Johnson, P. W., White, L. J., et al. (2023) · medRxiv · doi:10.1101/2023.10.16.23297100 · Cited by 6 · see citing works

Long-read RNA-seq atlas of novel microglia isoforms elucidates disease-associated genetic regulation of splicingPreprint

Humphrey, J., Brophy, E., Kosoy, R., Zeng, B., Coccia, E., Mattei, D., Ravi, A., Efthymiou, A. G., Navarro, E., Muller, B. Z., et al. (2023) · medRxiv · doi:10.1101/2023.12.01.23299073 · Cited by 5 · see citing works

Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2

Dues, D. J., Ma, Y., Nguyen, A. P. T., Offerman, A. V., Beddows, I., & Moore, D. J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106338 · Cited by 4 · see citing works

Leucine-Rich Repeat Kinase-2 Controls the Differentiation and Maturation of Oligodendrocytes in Mice and Zebrafish

Filippini, A., Cannone, E., Mazziotti, V., Carini, G., Mutti, V., Ravelli, C., Gennarelli, M., Schiavone, M., & Russo, I. (2024) · Biomolecules · doi:10.3390/biom14070870 · Cited by 4 · see citing works

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson’s Disease: Comparative Analysis of G2019S and I1371V Variants

Singh, K., Banerjee, R., Potdar, C., Shaw, A., Rakshith, R., Kamble, N. L., Holla, V., Yadav, R., Pal, P. K., & Datta, I. (2026) · Cells · doi:10.3390/cells15040342 · Cited by 3 · see citing works

LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal DegenerationPreprint

Giachino, C., Tirolo, C., Caniglia, S., Serapide, M. F., L’Episcopo, F., Bertoli, F., Giuliano, C., Mearelli, M., Jakobi, M., Schneiderhan‐Marra, N., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.01.505977 · Cited by 3 · see citing works

Single-cell transcriptomic changes in oligodendroglial lineage cells derived from Parkinson’s disease patient-iPSCs with LRRK2-G2019S mutationPreprint

Dehestani, M., Kessler, W., Karmali, N., Sun, W., Volos, P., Tsitkov, S., Dhingra, A., Rodrı́guez-Nieto, S., Tietz, J., Schafflick, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.01.601392 · Cited by 3 · see citing works

Editorial on: Confirmation of RAB32 Ser71Arg involvement in Parkinson's disease

Gustavsson, E. K. (2025) · Movement Disorders · doi:10.1002/mds.30080 · Cited by 3 · see citing works

Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal GangliaPreprint

Chang, L., Li, K., Xie, Y., Zhong, G., Rink, J. A., Báez-Becerra, C. T., Lie, A., Indralingam, H. S., Dong, K., Loe, T. H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.03.703645 · Cited by 4 · see citing works

Unraveling the enigma: housekeeping gene Ugt1a7c as a universal biomarker for microglia

Kim, W., Kim, M.-J., & Kim, B. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1364201 · Cited by 2 · see citing works

Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable for Parkinson’s disease

Phillips, B., Western, D., Wang, L., Timsina, J., Sun, Y., Gorijala, P., Yang, C., Do, A., Nykänen, N.-P., Alvarez, I., et al. (2023) · doi:10.1101/2023.01.05.23284241 · Cited by 20 · see citing works

The human microglia responsome: a resource to better understand microglia states in health and diseasePreprint

Snijders, G. J. L., Lopes, K. D. P., Sneeboer, M. A. M., Muller, B. Z., Gigase, F. A. J., Vialle, R. A., Missall, R. D., Kübler, R., Raj, T., Humphrey, J., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3433713/v1 · Cited by 2 · see citing works

APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal CortexPreprint

Huuki-Myers, L. A., Divecha, H. R., Bach, S. V., Valentine, M. R., Eagles, N. J., Mulvey, B., Bharadwaj, R. A., Zhang, R., Evans, J. R., Grant‐Peters, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.20.689483 · Cited by 3 · see citing works

New gene involved in the pathogenesis of Parkinson's disease

Toft, M. (2024) · The Lancet Neurology · doi:10.1016/s1474-4422(24)00166-2 · Cited by 1 · see citing works

LRRK2 kinase mediates increased GCase activity in microglia in response to IFNγ-induced proinflammatory stimulation

MacDougall, E. J., Chen, C. X. ‐., Deneault, É., You, Z., Kalaydjian, D., Abdian, N., Durcan, T. M., Senkevich, K. A., Gan‐Or, Z., & Fon, E. A. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01310-1 · Cited by 3 · see citing works

Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice

Beilina, A. G., Park, J.-H., Landeck, N., Chia, R., Ding, J., Reed, X., Bailey, H. M., Kim, C., Kaganovich, A., Acri, D. J., et al. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00938-0 · Cited by 1 · see citing works

Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cells

Kim, D., Kondo, T., & Inoue, H. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102866 · Cited by 1 · see citing works

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress

Sakurai, M., Kuwahara, T., Suenaga, S., Takatori, S., Tomita, T., Shalit, T., Tengstrand, E., Hsieh, F., & Iwatsubo, T. (2026) · iScience · doi:10.1016/j.isci.2026.117203 · Cited by 1 · see citing works

Lysosomal dysfunction in neurodegenerative disease

Brooker, S. M., Coukos, R., & Krainc, D. (2026) · Nature Reviews Neurology · doi:10.1038/s41582-026-01262-3 · Cited by 1 · see citing works

The versatile applications of human pluripotent stem cell-derived microglia and microglia-containing brain organoids

Wu, J., & Tang, Y. (2023) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2023.01 · Cited by 1 · see citing works

NADG-GAM: Neighbor aggregation-based neurological disease–gene identification via optimal generative adjacency matrix

Jin, M., Deng, Z., Zhang, Y., Liu, J., & Hu, F. (2025) · Applied Soft Computing · doi:10.1016/j.asoc.2025.112756 · Cited by 1 · see citing works

KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS diseasePreprint

Rodríguez-Nunez, I., Bartley, S. C., Taylor, J. W., Johnston, S. Q., Rogers, B. B., Meadows, S. K., Newberry, K. M., Cochran, J. N., & Myers, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.30.657077 · Cited by 1 · see citing works

LRRK2 Kinase Mediates Increased GCase Activity in Microglia in Response to Proinflammatory StimuliPreprint

MacDougall, E. J., Chen, C. X. ‐., Deneault, É., You, Z., Abdian, N., Durcan, T. M., Senkevich, K. A., Gan‐Or, Z., & Fon, E. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.10.681687 · Cited by 1 · see citing works

Biomarkers of LRRK2 and lysosomal dysfunction in Progressive Supranuclear PalsyPreprint

Nielsen, L.-K., Frost, J. L., Vaughan, D. P., Real, R., Fumi, R., Jensen, M. T., Hodgson, M., Stafford, E. J., Wu, L., Ansorge, O., et al. (2025) · medRxiv · doi:10.1101/2025.11.24.25340830 · Cited by 1 · see citing works

PINK1 loss in astrocytes triggers inflammatory dysfunction and neuronal deathPreprint

Fiorino, G., Florio, D. N. D., Hadley, D. H., Ross, O. A., Fiesel, F. C., & Springer, W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.04.729996 · Cited by 1 · see citing works

LRRK2-G2019S Synergizes With Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation That Precede Nigrostriatal DegenerationPreprint

Marchetti, B., Giachino, C., Tirolo, C., Caniglia, S., Serapide, M. F., L’Episcopo, F., Bertoli, F., Giuliano, C., Mearelli, M., Jakobi, M., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2044882/v1

Age-related disease: Central nervous system

Fossel, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00005-0

The OMICS and PD models: Hopes or hypes

Elsamman, K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-16128-5.00020-7

Profiling X chromosome genes expression relevant to sex dimorphism in stroke: insights from transcriptomics landscape analysis

Qin, X., Li, Y., Cai, Q., Liu, J., Dang, Z.-H., Li, L., Min, J., Qi, S., & Bu, F. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1479270

Dysfunctional Alternative Polyadenylation Modifies the Penetrance of LRRK2 Variants in Parkinson's Disease

Yang, S., Zhu, Y., Yu, P., Huang, Y., Wang, Z., Wang, Y., Zhou, Q., Zhang, Y., Li, B., Zhao, G., et al. (2025) · Movement Disorders · doi:10.1002/mds.70119

Additional file 10 of Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Figshare · doi:10.6084/m9.figshare.26759750

Additional file 6 of Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Figshare · doi:10.6084/m9.figshare.26759738

Additional file 4 of Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Figshare · doi:10.6084/m9.figshare.26759732

Additional file 1 of Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation

Yuan, Y., Li, H., Sreeram, K., Malankhanova, T. B., Boddu, R., Strader, S., Chang, A., Bryant, N., Yacoubian, T. A., Standaert, D. G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26019592

Additional file 3 of Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation

Yuan, Y., Li, H., Sreeram, K., Malankhanova, T. B., Boddu, R., Strader, S., Chang, A., Bryant, N., Yacoubian, T. A., Standaert, D. G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26732620

Additional file 8 of Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Figshare · doi:10.6084/m9.figshare.26759744

Additional file 9 of Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Figshare · doi:10.6084/m9.figshare.26759747

Additional file 11 of Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Figshare · doi:10.6084/m9.figshare.26759753

Additional file 7 of Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Figshare · doi:10.6084/m9.figshare.26759741

Additional file 2 of Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation

Yuan, Y., Li, H., Sreeram, K., Malankhanova, T. B., Boddu, R., Strader, S., Chang, A., Bryant, N., Yacoubian, T. A., Standaert, D. G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26019737

Additional file 1 of Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Figshare · doi:10.6084/m9.figshare.26759723

Additional file 3 of Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Figshare · doi:10.6084/m9.figshare.26759729

Additional file 5 of Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease

Dehestani, M., Kozareva, V., Blauwendraat, C., Fraenkel, E., Gasser, T., & Bansal, V. (2024) · Figshare · doi:10.6084/m9.figshare.26759735

The screening of the 3′UTR sequence of LRRK2 identified an association between the rs66737902 polymorphism and Parkinson’s disease

Cardo, L. F., Coto, E., Ribacoba, R., Mata, I. F., Morís, G., Menéndez‐González, M., & Álvarez, V. (2014) · Journal of Human Genetics · doi:10.1038/jhg.2014.26 · Cited by 19 · see citing works

Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk

Lake, J., Reed, X., Langston, R. G., Nalls, M. A., Gan‐Or, Z., Cookson, M., Singleton, A., Blauwendraat, C., & Leonard, H. L. (2021) · Movement Disorders · doi:10.1002/mds.28787 · Cited by 37 · see citing works

LRRK2 coding variants and the risk of Parkinson’s diseasePreprint

Lake, J., Reed, X., Langston, R. G., Nalls, M. A., Gan‐Or, Z., Cookson, M., Singleton, A., Blauwendraat, C., & Leonard, H. L. (2021) · medRxiv · doi:10.1101/2021.04.22.21255928 · Cited by 1 · see citing works

Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function

Ohtonen, S., Giudice, L., Jäntti, H., Fazaludeen, M. F., Shakirzyanova, A., Gómez‐Budia, M., Välimäki, N., Niskanen, J., Korvenlaita, N., Fagerlund, I., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-49294-9 · Cited by 21 · see citing works

Identification & characterization of leucine-rich repeat kinase 2 & parkin RBR E3 ubiquitin protein ligase variants in patients with Parkinson's disease

Halder, T., Verma, S. P., Raj, J., Pandey, S., Singh, R. K., Sharma, V., Joshi, D., & Das, P. K. (2020) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_730_18 · Cited by 2 · see citing works