Zhang, Dongyan

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerLipid metabolism and biosynthesis

Cited by 1,561

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

Perry, R. J., Peng, L., Barry, N. A., Cline, G. W., Zhang, D., Cardone, R. L., Petersen, K. F., Kibbey, R. G., Goodman, A. L., & Shulman, G. I. (2016) · Nature

Gut microbiota and healthRegulation of Appetite and Obesity

Cited by 1,299

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

Perry, R. J., Camporez, J.-P. G., Kursawe, R., Titchenell, P. M., Zhang, D., Perry, C. J., Jurczak, M. J., Abudukadier, A., Han, M. S., Zhang, X.-M., et al. (2015) · Cell

Adipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesis

Cited by 719

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Kumashiro, N., Erion, D. M., Zhang, D., Kahn, M., Beddow, S. A., Chu, X., Still, C. D., Gerhard, G. S., Han, X., Dziura, J., et al. (2011) · Proceedings of the National Academy of Sciences

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 585

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

Szendroedi, J., Yoshimura, T., Phielix, E., Koliaki, C., Marcucci, M., Zhang, D., Jelenik, T., Müller, J., Herder, C., Nowotny, P., et al. (2014) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 415

Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance

Choi, C. S., Savage, D. B., Kulkarni, A., Yu, X. X., Liu, Z.-X., Morino, K., Kim, S., Distefano, A., Samuel, V. T., Neschen, S., et al. (2007) · Journal of Biological Chemistry

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 383

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Sun, Z., Miller, R. A., Patel, R. T., Chen, J., Dhir, R., Wang, H., Zhang, D., Graham, M. J., Unterman, T. G., Shulman, G. I., et al. (2012) · Nature Medicine

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 335

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Choi, C. S., Savage, D. B., Abu-Elheiga, L., Liu, Z.-X., Kim, S., Kulkarni, A., Distefano, A., Hwang, Y.-J., Reznick, R. M., Codella, R., et al. (2007) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 325

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance

Lee, H.-Y., Choi, C. S., Birkenfeld, A. L., Alves, T. C., Jornayvaz, F. R., Jurczak, M. J., Zhang, D., Woo, D. K., Shadel, G. S., Ladiges, W., et al. (2010) · Cell Metabolism

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 319

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

Zhang, D., Liu, Z.-X., Choi, C. S., Tian, L., Kibbey, R., Dong, J., Cline, G. W., Wood, P. A., & Shulman, G. I. (2007) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerLiver Disease Diagnosis and Treatment

Cited by 291

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

Perry, R. J., Zhang, D., Zhang, X.-M., Boyer, J. L., & Shulman, G. I. (2015) · Science

Liver Disease Diagnosis and TreatmentMetabolism, Diabetes, and Cancer

Cited by 283

Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

Choi, C. S., Befroy, D. E., Codella, R., Kim, S., Reznick, R. M., Hwang, Y.-J., Liu, Z.-X., Lee, H.-Y., Distefano, A., Samuel, V. T., et al. (2008) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 279

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

Neschen, S., Morino, K., Hammond, L. E., Zhang, D., Liu, Z.-X., Romanelli, A. J., Cline, G. W., Pongratz, R. L., Zhang, X.-M., Choi, C. S., et al. (2005) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 261

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance

Nagai, Y., Yonemitsu, S., Erion, D. M., Iwasaki, T., Stark, R., Weismann, D., Dong, J., Zhang, D., Jurczak, M. J., Löffler, M. G., et al. (2009) · Cell Metabolism

Diet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

Cited by 203

Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis

Perry, R. J., Zhang, D., Guerra, M. T., Brill, A. L., Goedeke, L., Nasiri, A. R., Rabin-Court, A., Wang, Y., Peng, L., Dufour, S., et al. (2020) · Nature

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 186

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

Perry, R. J., Lee, S., Ma, L., Zhang, D., Schlessinger, J., & Shulman, G. I. (2015) · Nature Communications

Fibroblast Growth Factor ResearchPancreatic function and diabetes

Cited by 132

Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease

ter Horst, K. W., Vatner, D. F., Zhang, D., Cline, G. W., Ackermans, M. T., Nederveen, A. J., Verheij, J., Demirkiran, A., van Wagensveld, B. A., Dallinga-Thie, G. M., et al. (2021) · Diabetes Care

Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 88

Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance

Camporez, J. P., Lyu, K., Goldberg, E. L., Zhang, D., Cline, G. W., Jurczak, M. J., Dixit, V. D., Petersen, K. F., & Shulman, G. I. (2019) · The Journal of Physiology

Adipokines, Inflammation, and Metabolic DiseasesEstrogen and related hormone effects

Cited by 71