Li, Ronald A.

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

Zangi, L., Lui, K. O., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. M., Später, D., Xu, H., Tabebordbar, M., Gorbatov, R., et al. (2013) · Nature Biotechnology

Congenital heart defects researchMesenchymal stem cell research

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Functional Integration of Electrically Active Cardiac Derivatives From Genetically Engineered Human Embryonic Stem Cells With Quiescent Recipient Ventricular Cardiomyocytes: Insights Into the Development of Cell-Based Pacemakers

Xue, T., Cho, H. C., Akar, F. G., Tsang, S.-Y., Jones, S. P., Marbán, E., Tomaselli, G. F., & Li, R. A. (2005) · Circulation

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

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Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium

Turnbull, I. C., Karakikes, I., Serrao, G. W., Backeris, P., Lee, J., Xie, C., Senyei, G., Gordon, R. E., Li, R. A., Akar, F. G., et al. (2014) · The FASEB Journal

Tissue Engineering and Regenerative MedicinePluripotent Stem Cells Research

Cited by 184

Absence of Transverse Tubules Contributes to Non-Uniform Ca 2+ Wavefronts in Mouse and Human Embryonic Stem Cell–Derived Cardiomyocytes

Lieu, D. K., Liu, J., Siu, C.-W., McNerney, G. P., Tse, H.-F., Abu-Khalil, A., Huser, T., & Li, R. A. (2009) · Stem Cells and Development

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

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A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells

Weng, Z., Kong, C.-W., Ren, L., Karakikes, I., Geng, L., He, J., Chow, M. Z. Y., Mok, C. F., Chan, H. Y. S., Webb, S. E., et al. (2014) · Stem Cells and Development

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 109

Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes

Keung, W., Boheler, K. R., & Li, R. A. (2014) · Stem Cell Research & Therapy

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 87

Human cardiac ventricular-like organoid chambers and tissue strips from pluripotent stem cells as a two-tiered assay for inotropic responses

Keung, W., Chan, P. K. W., Backeris, P. C., Lee, E. K., Wong, N., Wong, A. O. T., Wong, G. K. Y., Chan, C. W. Y., Fermini, B., Costa, K. D., et al. (2019) · Clinical Pharmacology & Therapeutics

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

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A micropatterned human pluripotent stem cell-based ventricular cardiac anisotropic sheet for visualizing drug-induced arrhythmogenicity

Shum, A. M. Y., Che, H., Wong, A. O., Zhang, C., Wu, H., Chan, C. W. Y., Costa, K., Khine, M., Kong, C., & Li, R. A. (2017) · Advanced Materials

Cardiac electrophysiology and arrhythmiasTissue Engineering and Regenerative Medicine

Cited by 37

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Pancreatic β-Cells

El-Kholy, W., MacDonald, P. E., Fox, J. M., Bhattacharjee, A., Xue, T., Gao, X., Zhang, Y., Stieber, J., Li, R. A., Tsushima, R. G., et al. (2007) · Molecular Endocrinology

Pancreatic function and diabetesIon channel regulation and function

Cited by 33

Correlation between frataxin expression and contractility revealed by in vitro Friedreich’s ataxia cardiac tissue models engineered from human pluripotent stem cells

Wong, A. O.-T., Wong, G., Shen, M., Chow, M. Z.-Y., Tse, W. W., Gurung, B., Mak, S. Y., Lieu, D. K., Costa, K. D., Chan, C. W., et al. (2019) · Stem Cell Research & Therapy

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

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Overexpression of Kir2.1 channel in embryonic stem cell-derived cardiomyocytes attenuates posttransplantation proarrhythmic risk in myocardial infarction

Liao, S.-Y., Tse, H.-F., Chan, Y.-C., Mei-Chu Yip, P., Zhang, Y., Liu, Y., & Li, R. A. (2013) · Heart Rhythm

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

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Mechanistic basis of excitation-contraction coupling in human pluripotent stem cell-derived ventricular cardiomyocytes revealed by Ca2+ spark characteristics: direct evidence of functional Ca2+-induced Ca2+ release

Li, S., Cheng, H., Tomaselli, G. F., & Li, R. A. (2014) · Heart Rhythm

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

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Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues

Wong, A. O.-T., Gurung, B., Wong, W. S., Mak, S. Y., Tse, W. W., Li, C. M., Lieu, D. K., Costa, K. D., Li, R. A., & Hajjar, R. J. (2021) · Journal of Molecular and Cellular Cardiology

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

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Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Cashman, T. J., Josowitz, R., Gelb, B. D., Li, R. A., Dubois, N. C., & Costa, K. D. (2016) · Journal of Visualized Experiments

Tissue Engineering and Regenerative MedicinePluripotent Stem Cells Research

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Reversal of contractile defects by mediating calcium homeostasis in human mini-heart models of heart failure with preserved ejection fraction (HFpEF) leads to first-in-human gene therapy clinical trial

Costa, K. D., Wong, A. O. T., Mak, S. Y., Roberts, E. G., Keung, W., Correia, C., Walentinsson, A., Christoffersson, J., Cheung, A., Lieu, D. K., et al. (2024) · bioRxiv

Cardiac electrophysiology and arrhythmiasCardiovascular Function and Risk Factors

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