Tan, Jessie

IL-11 is a crucial determinant of cardiovascular fibrosis

Schafer, S., Viswanathan, S., Widjaja, A. A., Lim, W.-W., Moreno-Moral, A., DeLaughter, D. M., Ng, B., Patone, G., Chow, K., Khin, E., et al. (2017) · Nature

Cardiac Fibrosis and RemodelingTGF-β signaling in diseases

Cited by 639

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

Ng, B., Dong, J., D’Agostino, G., Viswanathan, S., Widjaja, A. A., Lim, W.-W., Ko, N. S. J., Tan, J., Chothani, S. P., Huang, B., et al. (2019) · Science Translational Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and Treatments

Cited by 314

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

Widjaja, A. A., Lim, W.-W., Viswanathan, S., Chothani, S., Corden, B., Dasan, C. M., Goh, J. W. T., Lim, R., Singh, B. K., Tan, J., et al. (2024) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 238

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

Widjaja, A. A., Viswanathan, S., Wei Ting, J. G., Tan, J., Shekeran, S. G., Carling, D., Lim, W.-W., & Cook, S. A. (2022) · iScience

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 45