Cited by 314Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and TreatmentsTransplantation: Methods and Outcomes

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

Open access
Ng, Benjamin, Dong, Jinrui, D’Agostino, Giuseppe, Viswanathan, Sivakumar, Widjaja, Anissa A., Lim, Wei-Wen, Ko, Nicole S. J., Tan, Jessie +14 more·2019·Science Translational Medicine

Published version of a preprint

Abstract

Interleukin-11 is important for lung fibroblast activation in idiopathic pulmonary fibrosis, and its signaling represents a therapeutic target.

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Crossref · 10.1126/scitranslmed.aaw1237

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  • IL-11 is a key driver of myofibroblast activation and differentiation in IPF.

    “IL-11 is a key driver of myofibroblast activation and differentiation in IPF41”
  • Microbiota-driven intestinal fibrosis may be mediated by induction of the IL-33 receptor ST2 on epithelial cells or by the pro-fibrotic action of TL1A.

    “Microbiota driven intestinal fibrosis may be mediated by induction of the IL-33 receptor ST2 on epithelial cells157 or the pro-fibrotic action of tumor necrosis factor-like cytokine 1A (TL1A)158”

    From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [158]

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Authors
Ng, B., Dong, J., D’Agostino, G., Viswanathan, S., Widjaja, A. A., Lim, W.-W., Ko, N. S. J., Tan, J., Chothani, S. P., Huang, B., Xie, C., Pua, C. J., Chacko, A.-M., Guimarães-Camboa, N., Evans, S. M., Byrne, A. J., Maher, T. M., Liang, J., Jiang, D., Noble, P. W., Schafer, S., & Cook, S. A.
Affiliations
  • National University of Singapore (SG)
  • National Heart Centre Singapore (SG)
  • Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt 60590, Germany.
  • Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  • Imperial College London (GB)
  • Royal Brompton Hospital (GB)
  • Cedars-Sinai Medical Center (US)
  • National Heart Centre Singapore, 169609 Singapore, Singapore.
Corresponding author
  • Ng, Benjamin
  • Dong, Jinrui
  • D’Agostino, Giuseppe
  • Cook, Stuart A.
Venue
Science Translational Medicine
Published
2019-09-25
Volume
11
Issue
511
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2975410560
Cited by
314
References
92
Citations by year
2026: 41 · 2025: 42 · 2024: 51 · 2023: 45 · 2022: 45 · 2021: 55 · 2020: 29 · 2019: 6
FWCI
24.67
Type
journal article
Language
en
Open access
Licence
cc-by-nd
Locations
  • Science Translational Medicine (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
  • PubMed (publishedVersion)
Funders
  • National Medical Research Council (NMRC) Singapore (NMRC/OFYIRG/0053/2017)
  • NIHR Clinician Scientist Fellowship (HIHR Ref: CS-2013-13-017)
  • British Lung Foundation Chair in Respiratory Research (C17-3)
  • the National Medical Research Council (NMRC) Singapore STaR awards (NMRC/STaR/0011/2012)
  • National Medical Research Council (NMRC) Singapore STaR awards (NMRC/STaR/0029/2017)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords
interleukin-11, idiopathic pulmonary fibrosis, pulmonary fibrosis, lung fibroblast activation, myofibroblast activation, bleomycin-induced fibrosis, ERK signaling, Smad signaling, lung inflammation, therapeutic target
MeSH terms
Animals, Bleomycin, Fibroblasts, Humans, Lung, Severity of Illness Index, Signal Transduction, Up-Regulation, Interleukin-11, Mice, Knockout, Interleukin-11 Receptor alpha Subunit, Idiopathic Pulmonary Fibrosis, Antibodies, Neutralizing

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