Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
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Abstract
Interleukin-11 is important for lung fibroblast activation in idiopathic pulmonary fibrosis, and its signaling represents a therapeutic target.
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IL-11 is a key driver of myofibroblast activation and differentiation in IPF.
“IL-11 is a key driver of myofibroblast activation and differentiation in IPF41”
From Inhaled LTI-03 for idiopathic pulmonary fibrosis: a randomized dose escalation study (2026) · cites this paper as [41]
Microbiota-driven intestinal fibrosis may be mediated by induction of the IL-33 receptor ST2 on epithelial cells or by the pro-fibrotic action of TL1A.
“Microbiota driven intestinal fibrosis may be mediated by induction of the IL-33 receptor ST2 on epithelial cells157 or the pro-fibrotic action of tumor necrosis factor-like cytokine 1A (TL1A)158”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [158]
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Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart
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Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes?
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Cross-Talk between Transforming Growth Factor-β and Periostin Can Be Targeted for Pulmonary Fibrosis
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Self-citationEngrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation
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Host IL11 Signaling Suppresses CD4+ T cell–Mediated Antitumor Responses to Colon Cancer in Mice
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Self-citationInterleukin-11 drives human and mouse alcohol-related liver disease
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Self-citationThe cytokine interleukin-11 crucially links bone formation, remodeling and resorption
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Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases
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- Authors
- Ng, B., Dong, J., D’Agostino, G., Viswanathan, S., Widjaja, A. A., Lim, W.-W., Ko, N. S. J., Tan, J., Chothani, S. P., Huang, B., Xie, C., Pua, C. J., Chacko, A.-M., Guimarães-Camboa, N., Evans, S. M., Byrne, A. J., Maher, T. M., Liang, J., Jiang, D., Noble, P. W., Schafer, S., & Cook, S. A.
- Affiliations
- National University of Singapore (SG)
- National Heart Centre Singapore (SG)
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt 60590, Germany.
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
- Imperial College London (GB)
- Royal Brompton Hospital (GB)
- Cedars-Sinai Medical Center (US)
- National Heart Centre Singapore, 169609 Singapore, Singapore.
- Corresponding author
- Ng, Benjamin
- Dong, Jinrui
- D’Agostino, Giuseppe
- Cook, Stuart A.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-09-25
- Volume
- 11
- Issue
- 511
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2975410560
- Semantic Scholar
- 707edf16b55c02f433b992ddc906064a1c8f30f7
- Cited by
- 314
- References
- 92
- Citations by year
- 2026: 41 · 2025: 42 · 2024: 51 · 2023: 45 · 2022: 45 · 2021: 55 · 2020: 29 · 2019: 6
- FWCI
- 24.67
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nd
- Locations
- Science Translational Medicine (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
- PubMed (publishedVersion)
- Funders
- National Medical Research Council (NMRC) Singapore (NMRC/OFYIRG/0053/2017)
- NIHR Clinician Scientist Fellowship (HIHR Ref: CS-2013-13-017)
- British Lung Foundation Chair in Respiratory Research (C17-3)
- the National Medical Research Council (NMRC) Singapore STaR awards (NMRC/STaR/0011/2012)
- National Medical Research Council (NMRC) Singapore STaR awards (NMRC/STaR/0029/2017)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- interleukin-11, idiopathic pulmonary fibrosis, pulmonary fibrosis, lung fibroblast activation, myofibroblast activation, bleomycin-induced fibrosis, ERK signaling, Smad signaling, lung inflammation, therapeutic target
- MeSH terms
- Animals, Bleomycin, Fibroblasts, Humans, Lung, Severity of Illness Index, Signal Transduction, Up-Regulation, Interleukin-11, Mice, Knockout, Interleukin-11 Receptor alpha Subunit, Idiopathic Pulmonary Fibrosis, Antibodies, Neutralizing
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