Vicini, Paolo

Discovery of N-((3 R,4 R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H-pyrazol-4-yl)amino)-9-methyl-9 H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Planken, S., Behenna, D. C., Nair, S. K., Johnson, T. O., Nagata, A., Almaden, C., Bailey, S., Ballard, T. E., Bernier, L., Cheng, H., et al. (2017) · Journal of Medicinal Chemistry

Lung Cancer Treatments and MutationsComputational Drug Discovery Methods

Cited by 97

Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle

Bartelink, I. H., Jones, E. F., Shahidi‐Latham, S. K., Lee, P. R. E., Zheng, Y., Vicini, P., van ‘t Veer, L., Wolf, D., Iagaru, A., Kroetz, D. L., et al. (2019) · Clinical Pharmacology & Therapeutics

Computational Drug Discovery MethodsDrug Transport and Resistance Mechanisms

Cited by 96

Multiscale Modeling in the Clinic: Drug Design and Development

Clancy, C. E., An, G., Cannon, W. R., Liu, Y., May, E. E., Ortoleva, P., Popel, A. S., Sluka, J. P., Su, J., Vicini, P., et al. (2016) · Annals of Biomedical Engineering

Computational Drug Discovery MethodsStatistical Methods in Clinical Trials

Cited by 62

Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network

Cucurull‐Sanchez, L., Chappell, M. J., Chelliah, V., Amy Cheung, S. Y., Derks, G., Penney, M., Phipps, A., Malik‐Sheriff, R. S., Timmis, J., Tindall, M. J., et al. (2019) · CPT: Pharmacometrics & Systems Pharmacology

Computational Drug Discovery MethodsStatistical Methods in Clinical Trials

Cited by 61

Integrated model of hepatic and peripheral glucose regulation for estimation of endogenous glucose production during the hot IVGTT

Krudys, K. M., Dodds, M. G., Nissen, S. M., & Vicini, P. (2005) · American Journal of Physiology-Endocrinology and Metabolism

Pancreatic function and diabetesDiabetes Management and Research

Cited by 30

Detecting bliss synergy in in vivo combination studies with a tumor kinetic model

Zhao, W., Vicini, P., Novick, S., Anderton, J., Davies, G., DAngelo, G., O'Day, T., Yu, B., Harper, J., Narwal, R., et al. (2019) · Pharmaceutical Statistics

Mathematical Biology Tumor GrowthStatistical Methods in Clinical Trials

Cited by 4