Kumar, Asok

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology

Autophagy in Disease and TherapyAlzheimer's disease research and treatments

Cited by 1,588

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

Lee, J.-H., Yu, W. H., Kumar, A., Lee, S., Mohan, P. S., Peterhoff, C. M., Wolfe, D. M., Martinez-Vicente, M., Massey, A. C., Sovak, G., et al. (2010) · Cell

Autophagy in Disease and TherapyAlzheimer's disease research and treatments

Cited by 1,212

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

Yu, W. H., Cuervo, A. M., Kumar, A., Peterhoff, C. M., Schmidt, S. D., Lee, J.-H., Mohan, P. S., Mercken, M., Farmery, M. R., Tjernberg, L. O., et al. (2005) · The Journal of Cell Biology

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 967

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer’s disease ameliorates amyloid pathologies and memory deficits

Yang, D.-S., Stavrides, P., Mohan, P. S., Kaushik, S., Kumar, A., Ohno, M., Schmidt, S. D., Wesson, D., Bandyopadhyay, U., Jiang, Y., et al. (2011) · Brain

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 429

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

Lee, J.-H., McBrayer, M. K., Wolfe, D. M., Haslett, L. J., Kumar, A., Sato, Y., Lie, P. P. Y., Mohan, P., Coffey, E. E., Kompella, U., et al. (2015) · Cell Reports

Calcium signaling and nucleotide metabolismAlzheimer's disease research and treatments

Cited by 358

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides

TOKUDA, T., CALERO, M., MATSUBARA, E., VIDAL, R., KUMAR, A., PERMANNE, B., ZLOKOVIC, B., SMITH, J. D., LADU, M. J., ROSTAGNO, A., et al. (2000) · Biochemical Journal

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 272

Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)

Jiang, Y., Sato, Y., Im, E., Berg, M., Bordi, M., Darji, S., Kumar, A., Mohan, P. S., Bandyopadhyay, U., Diaz, A., et al. (2019) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 166

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

Bordi, M., Darji, S., Sato, Y., Mellén, M., Berg, M. J., Kumar, A., Jiang, Y., & Nixon, R. A. (2019) · Cell Death & Disease

Autophagy in Disease and TherapyDown syndrome and intellectual disability research

Cited by 124

Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

Yang, D.-S., Stavrides, P., Saito, M., Kumar, A., Rodriguez-Navarro, J. A., Pawlik, M., Huo, C., Walkley, S. U., Saito, M., Cuervo, A. M., et al. (2014) · Brain

Autophagy in Disease and TherapyAlzheimer's disease research and treatments

Cited by 114

Functional and structural properties of lipid-associated apolipoprotein J (clusterin)

CALERO, M., TOKUDA, T., ROSTAGNO, A., KUMAR, A., ZLOKOVIC, B., FRANGIONE, B., & GHISO, J. (1999) · Biochemical Journal

Clusterin in disease pathologyProtein Structure and Dynamics

Cited by 98

Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their Stability In Vivo

Planel, E., Krishnamurthy, P., Miyasaka, T., Liu, L., Herman, M., Kumar, A., Bretteville, A., Figueroa, H. Y., Haung Yu, W., Whittington, R. A., et al. (2008) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsAnesthesia and Neurotoxicity Research

Cited by 79