Bonner, William M.

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 5,438

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 2,422

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 2,098

γH2AX and cancer

Bonner, W. M., Redon, C. E., Dickey, J. S., Nakamura, A. J., Sedelnikova, O. A., Solier, S., & Pommier, Y. (2008) · Nature reviews. Cancer

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 1,623

Genomic Instability in Mice Lacking Histone H2AX

Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 1,385

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Celeste, A., Fernandez-Capetillo, O., Kruhlak, M. J., Pilch, D. R., Staudt, D. W., Lee, A., Bonner, R. F., Bonner, W. M., & Nussenzweig, A. (2003) · Nature Cell Biology

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 989

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

Sedelnikova, O. A., Horikawa, I., Zimonjic, D. B., Popescu, N. C., Bonner, W. M., & Barrett, J. C. (2004) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 790

Quantitative Detection of125IdU-Induced DNA Double-Strand Breaks with γ-H2AX Antibody

Sedelnikova, O. A., Rogakou, E. P., Panyutin, I. G., & Bonner, W. M. (2002) · Radiation Research

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 611

p21: a two-faced genome guardian.

Georgakilas, A. G., Martin, O. A., & Bonner, W. M. (2017) · Trends in Molecular Medicine

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 489

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes

Furuta, T., Takemura, H., Liao, Z.-Y., Aune, G. J., Redon, C., Sedelnikova, O. A., Pilch, D. R., Rogakou, E. P., Celeste, A., Chen, H. T., et al. (2003) · Journal of Biological Chemistry

DNA Repair MechanismsCancer therapeutics and mechanisms

Cited by 449

H2AX: functional roles and potential applications

Dickey, J. S., Redon, C. E., Nakamura, A. J., Baird, B. J., Sedelnikova, O. A., & Bonner, W. M. (2009) · Chromosoma

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 320

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, γ-H2AX formation, and Mre11 relocalization

Limoli, C. L., Giedzinski, E., Bonner, W. M., & Cleaver, J. E. (2002) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 210

Delayed kinetics of DNA double‐strand break processing in normal and pathological aging

Sedelnikova, O. A., Horikawa, I., Redon, C., Nakamura, A., Zimonjic, D. B., Popescu, N. C., & Bonner, W. M. (2008) · Aging Cell

DNA Repair MechanismsTelomeres, Telomerase, and Senescence

Cited by 207

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

Contrepois, K., Coudereau, C., Benayoun, B. A., Schuler, N., Roux, P.-F., Bischof, O., Courbeyrette, R., Carvalho, C., Thuret, J.-Y., Ma, Z., et al. (2017) · Nature Communications

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 191

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

Nakamura, A. J., Chiang, Y. J., Hathcock, K. S., Horikawa, I., Sedelnikova, O. A., Hodes, R. J., & Bonner, W. M. (2008) · Epigenetics & Chromatin

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 168

γH2AX in Bystander Cells: Not Just a Radiation-Triggered Event, a Cellular Response to Stress Mediated by Intercellular Communication

Sokolov, M. V., Dickey, J. S., Bonner, W. M., & Martin, O. A. (2007) · Cell Cycle

Effects of Radiation ExposureDNA Repair Mechanisms

Cited by 100

Collaborative roles of γH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair

Sonoda, E., Zhao, G. Y., Kohzaki, M., Dhar, P. K., Kikuchi, K., Redon, C., Pilch, D. R., Bonner, W. M., Nakano, A., Watanabe, M., et al. (2007) · DNA Repair

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 47

Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis

Weyemi, U., Paul, B. D., Snowman, A. M., Jailwala, P., Nussenzweig, A., Bonner, W. M., & Snyder, S. H. (2018) · Nature Communications

Redox biology and oxidative stressDNA Repair Mechanisms

Cited by 37

SOD2 deficiency promotes aging phenotypes in mouse skin

Weyemi, U., Parekh, P. R., Redon, C. E., & Bonner, W. M. (2012) · Aging

Redox biology and oxidative stressGenetics, Aging, and Longevity in Model Organisms

Cited by 30