γH2AX and cancer

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438 · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature · doi:10.1038/nature03482 · Cited by 2,688 · see citing works

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422 · see citing works

Topoisomerase I inhibitors: camptothecins and beyond

Pommier, Y. G. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1977 · Cited by 2,295 · see citing works

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098 · see citing works

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009 · see citing works

An Oncogene-Induced DNA Damage Model for Cancer Development

Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851 · see citing works

Radical causes of cancer

Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690 · see citing works

DNA repair pathways as targets for cancer therapy

Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2342 · Cited by 1,666 · see citing works

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

Rothkamm, K., & Löbrich, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0830918100 · Cited by 1,645 · see citing works

The Role of Oxidative Stress in Carcinogenesis

Klaunig, J. E., & Kamendulis, L. M. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121851 · Cited by 1,537 · see citing works

DNA Damage Foci at Dysfunctional Telomeres

Takai, H., Smogorzewska, A., & de Lange, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00542-6 · Cited by 1,409 · see citing works

Genomic Instability in Mice Lacking Histone H2AX

Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385 · see citing works

-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

Kinner, A., Wu, W., Staudt, C., & Iliakis, G. E. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn550 · Cited by 1,249 · see citing works

Living on a break: cellular senescence as a DNA-damage response

d'Adda di Fagagna, F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2440 · Cited by 1,170 · see citing works

RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

Mailand, N., Bekker‐Jensen, S., Kildegaard, H. F., Melander, F., Bártek, J., Lukas, C., & Lukas, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.040 · Cited by 1,153 · see citing works

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Ward, I. M., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100569200 · Cited by 1,150 · see citing works

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

Stiff, T., O’Driscoll, M., Rief, N., Iwabuchi, K., Löbrich, M., & Jeggo, P. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3207 · Cited by 1,010 · see citing works

H2AX: the histone guardian of the genome

Fernández-Capetillo, Ó., Lee, A., Nussenzweig, M. C., & Nussenzweig, A. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.024 · Cited by 1,001 · see citing works

Chronic inflammation and oxidative stress in human carcinogenesis

Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F., & Loguercio, C. (2007) · International Journal of Cancer · doi:10.1002/ijc.23192 · Cited by 1,001 · see citing works

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Celeste, A., Fernandez-Capetillo, O., Kruhlak, M. J., Pilch, D. R., Staudt, D. W., Lee, A., Bonner, R. F., Bonner, W. M., & Nussenzweig, A. (2003) · Nature Cell Biology · doi:10.1038/ncb1004 · Cited by 989 · see citing works

Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

Kolas, N. K., Chapman, J. R., Nakada, S., Ylanko, J., Chahwan, R., Sweeney, F. D., Panier, S., Mendez, M., Wildenhain, J., Thomson, T. M., et al. (2007) · Science · doi:10.1126/science.1150034 · Cited by 900 · see citing works

Recombinational DNA double-strand breaks in mice precede synapsis

Mahadevaiah, S. K., Turner, J. M. A., Baudat, F., Rogakou, E. P., de Boer, P., Blanco‐Rodríguez, J., Jasin, M., Keeney, S., Bonner, W. M., & Burgoyne, P. S. (2001) · Nature Genetics · doi:10.1038/85830 · Cited by 852 · see citing works

A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

Riballo, E., Kühne, M., Rief, N., Doherty, A., Smith, G. C. M., Recio, M.-J., Reis, C., Dahm, K., Fricke, A., Krempler, A., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.029 · Cited by 837 · see citing works

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., & Jeggo, P. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.017 · Cited by 836 · see citing works

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

Sedelnikova, O. A., Horikawa, I., Zimonjic, D. B., Popescu, N. C., Bonner, W. M., & Barrett, J. C. (2004) · Nature Cell Biology · doi:10.1038/ncb1095 · Cited by 790 · see citing works

Initiation of DNA Fragmentation during Apoptosis Induces Phosphorylation of H2AX Histone at Serine 139*

Rogakou, E., Nieves-Neira, W., Boon, C., Pommier, Y., & Bonner, W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9390 · Cited by 747 · see citing works

Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions

Kusch, T., Florens, L. A., McDonald, W. H., Swanson, S. K., Glaser, R. L., Yates, J. R., Abmayr, S. M., Washburn, M. P., & Workman, J. L. (2004) · Science · doi:10.1126/science.1103455 · Cited by 669 · see citing works

MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

Lou, Z., Minter‐Dykhouse, K., Franco, S., Gostissa, M., Rivera, M. A., Celeste, A., Manis, J. P., van Deursen, J., Nussenzweig, A., Paull, T. T., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.025 · Cited by 629 · see citing works

Wavelength dependence of oxidative DNA damage induced by UV and visible light

Kielbassa, C. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.811 · Cited by 616 · see citing works

Quantitative Detection of¹²⁵IdU-Induced DNA Double-Strand Breaks with γ-H2AX Antibody

Sedelnikova, O. A., Rogakou, E. P., Panyutin, I. G., & Bonner, W. M. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)158[0486:qdoiid]2.0.co;2 · Cited by 611 · see citing works

Recruitment of the INO80 Complex by H2A Phosphorylation Links ATP-Dependent Chromatin Remodeling with DNA Double-Strand Break Repair

van Attikum, H., Fritsch, O., Höhn, B., & Gasser, S. M. (2004) · Cell · doi:10.1016/j.cell.2004.11.033 · Cited by 609 · see citing works

H2AX Is Required for Chromatin Remodeling and Inactivation of Sex Chromosomes in Male Mouse Meiosis

Fernández-Capetillo, Ó., Mahadevaiah, S. K., Celeste, A., Romanienko, P. J., Camerini‐Otero, R. D., Bonner, W. M., Manova, K., Burgoyne, P. S., & Nussenzweig, A. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00093-5 · Cited by 598 · see citing works

Binding of Chromatin-Modifying Activities to Phosphorylated Histone H2A at DNA Damage Sites

Downs, J. A., Allard, S., Jobin‐Robitaille, O., Javaheri, A., Auger, A., Bouchard, N., Kron, S. J., Jackson, S. P., & Côté, J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.12.003 · Cited by 583 · see citing works

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works

DNA Damage Response Pathway Uses Histone Modification to Assemble a Double-Strand Break-Specific Cohesin Domain

Ünal, E., Arbel‐Eden, A., Sattler, U., Shroff, R., Lichten, M., Haber, J. E., & Koshland, D. E. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.027 · Cited by 568 · see citing works

INO80 and γ-H2AX Interaction Links ATP-Dependent Chromatin Remodeling to DNA Damage Repair

Morrison, A. J., Highland, J., Krogan, N. J., Arbel‐Eden, A., Greenblatt, J., Haber, J. E., & Shen, X. (2004) · Cell · doi:10.1016/j.cell.2004.11.037 · Cited by 567 · see citing works

γ-H2AX Dephosphorylation by Protein Phosphatase 2A Facilitates DNA Double-Strand Break Repair

Chowdhury, D., Keogh, M., Ishii, H., Peterson, C. L., Buratowski, S., & Lieberman, J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.003 · Cited by 549 · see citing works

H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

Celeste, A., Difilippantonio, S., Difilippantonio, M. J., Fernández-Capetillo, Ó., Pilch, D. R., Sedelnikova, O. A., Eckhaus, M., Ried, T., Bonner, W. M., & Nussenzweig, A. (2003) · Cell · doi:10.1016/s0092-8674(03)00567-1 · Cited by 548 · see citing works

DNA‐damage repair; the good, the bad, and the ugly

Hakem, R. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.15 · Cited by 547 · see citing works

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

McCulloch, S. D., & Kunkel, T. A. (2008) · Cell Research · doi:10.1038/cr.2008.4 · Cited by 538 · see citing works

The genetics of hereditary colon cancerPreprint

Rustgi, A. K. (2007) · Genes & Development · doi:10.1101/gad.1593107 · Cited by 528 · see citing works

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

Bassing, C. H., Chua, K. F., Sekiguchi, J., Suh, H., Whitlow, S. R., Fleming, J. C., Monroe, B., Ciccone, D. N., Yan, C. T., Vlasáková, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122228699 · Cited by 525 · see citing works

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

Kruhlak, M. J., Celeste, A., Dellaire, G., Fernandez-Capetillo, O., Müller, W. G., McNally, J. G., Bazett-Jones, D. P., & Nussenzweig, A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510015 · Cited by 518 · see citing works

Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations

Thirman, M. J., Gill, H. J., Burnett, R. C., Mbangkollo, D., McCabe, N. R., Kobayashi, H., der Poel, S. Z.-V., Kaneko, Y., Morgan, R., Sandberg, A. A., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199309233291302 · Cited by 501 · see citing works

Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break

Shroff, R., Arbel‐Eden, A., Pilch, D. R., Ira, G., Bonner, W. M., Petrini, J. H. J., Haber, J. E., & Lichten, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.047 · Cited by 499 · see citing works

Histone H2AX

Bassing, C. H., Suh, H., Ferguson, D. O., Chua, K. F., Manis, J. P., Eckersdorff, M., Gleason, M., Bronson, R. T., Lee, C., & Alt, F. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00566-x · Cited by 480 · see citing works

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

Kurz, E. U., & Lees‐Miller, S. P. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.029 · Cited by 478 · see citing works

A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery

Keogh, M., Kim, J., Downey, M., Fillingham, J., Chowdhury, D., Harrison, J. C., Onishi, M., Datta, N., Galicia, S., Emili, A., et al. (2005) · Nature · doi:10.1038/nature04384 · Cited by 471 · see citing works

VERY HIGH BACKGROUND RADIATION AREAS OF RAMSAR, IRAN: PRELIMINARY BIOLOGICAL STUDIES

Ghiassi-Nejad, M., Mortazavi, S. M. J., CAMERON, J. R., et al. (2002) · Health Physics · doi:10.1097/00004032-200201000-00011 · Cited by 457 · see citing works

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes

Furuta, T., Takemura, H., Liao, Z.-Y., Aune, G. J., Redon, C., Sedelnikova, O. A., Pilch, D. R., Rogakou, E. P., Celeste, A., Chen, H. T., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300198200 · Cited by 449 · see citing works

Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441

Zhao, Y., Thomas, H. D., Batey, M. A., Cowell, I. G., Richardson, C. J., Griffin, R. J., Calvert, H., Newell, D. R., Smith, G. C. M., & Curtin, N. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4275 · Cited by 447 · see citing works

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

Wang, B., & Elledge, S. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710061104 · Cited by 446 · see citing works

Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: A complex genotype–phenotype relationship

Kraemer, K. H., Patronas, N. J., Schiffmann, R., Brooks, B. P., Tamura, D., & DiGiovanna, J. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.020 · Cited by 443 · see citing works

Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

Lakatos, P. L., & Lakatos, L. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3937 · Cited by 443 · see citing works

In vivo formation and repair of DNA double-strand breaks after computed tomography examinations

Löbrich, M., Rief, N., Kühne, M., Heckmann, M. B., Fleckenstein, J., Rübe, C., & Uder, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501895102 · Cited by 425 · see citing works

γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes

Stucki, M., & Jackson, S. P. (2006) · DNA Repair · doi:10.1016/j.dnarep.2006.01.012 · Cited by 412 · see citing works

Telomere dysfunction and tumour suppression: the senescence connection

Deng, Y., Chan, S. S., & Chang, S. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2393 · Cited by 411 · see citing works

DNA topoisomerase II, genotoxicity, and cancer

McClendon, A. K., & Osheroff, N. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.06.009 · Cited by 407 · see citing works

DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N. K., Amunugama, R., Yoder, K. E., Izumi, S., Kuraoka, I., Tanaka, K., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00579-07 · Cited by 376 · see citing works

Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice

Fortune, J. M., & Osheroff, N. (2000) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(00)64006-0 · Cited by 367 · see citing works

Histone Modifications and Nuclear Architecture: A Review

Bártová, E., Krejčí, J., Harničarová, A., Galiová, G., & Kozubek, S. (2008) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2008.951251 · Cited by 366 · see citing works

ATR‐dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

Stiff, T., Walker, S. A., Cerosaletti, K., Goodarzi, A. A., Petermann, E., Concannon, P., O'Driscoll, M., & Jeggo, P. A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601446 · Cited by 360 · see citing works

Separation of basal histone synthesis from S-phase histone synthesis in dividing cells

Wu, R. S., & Bonner, W. M. (1981) · Cell · doi:10.1016/0092-8674(81)90415-3 · Cited by 360 · see citing works

H2AX phosphorylation within the G ₁ phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks

Marti, T. M., Hefner, E., Feeney, L., Natale, V., & Cleaver, J. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603779103 · Cited by 359 · see citing works

Cell Apoptosis: Requirement of H2AX in DNA Ladder Formation, but Not for the Activation of Caspase-3

Lu, C., Zhu, F., Cho, Y., Tang, F., Zykova, T. A., Ma, W., Bode, A. M., & Dong, Z. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.023 · Cited by 354 · see citing works

The mechanics of base excision repair, and its relationship to aging and disease

WILSONIII, D., & Bohr, V. A. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.017 · Cited by 342 · see citing works

Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double‐strand breaks

van Attikum, H., Fritsch, O., & Gasser, S. M. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601835 · Cited by 333 · see citing works

Trashing the genome: the role of nucleases during apoptosis

Samejima, K., & Earnshaw, W. C. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1715 · Cited by 312 · see citing works

Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location

Yauk, C. L., Polyzos, A. A., Rowan‐Carroll, A., Somers, C. M., Godschalk, R., van Schooten, F., Berndt, M. L., Pogribny, I. P., Koturbash, I., Williams, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705896105 · Cited by 312 · see citing works

Involvement of H2AX in the DNA Damage and Repair Response

Martin, O. A., Pilch, D. R., Redon, C. E., & Bonner, W. M. (2003) · Cancer Biology & Therapy · doi:10.4161/cbt.2.3.373 · Cited by 309 · see citing works

ATR-Chk2 Signaling in p53 Activation and DNA Damage Response during Cisplatin-induced Apoptosis

Pabla, N., Huang, S., Mi, Q.-S., Daniel, R., & Dong, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707568200 · Cited by 309 · see citing works

NBS1 Localizes to γ-H2AX Foci through Interaction with the FHA/BRCT Domain

Kobayashi, J., Tauchi, H., Sakamoto, S., Nakamura, A., Morishima, K.-I., Matsuura, S., Kobayashi, T., Tamai, K., Tanimoto, K., & Komatsu, K. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01259-9 · Cited by 306 · see citing works

DNA Strand Break Repair and Human Genetic Disease

McKinnon, P. J., & Caldecott, K. W. (2007) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115648 · Cited by 303 · see citing works

Untitled work

(2003) · PubMed · Cited by 290 · see citing works

Phosphorylation of histone H2AX as a measure of radiosensitivity

Olive, P. L., & Banáth, J. P. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2003.09.028 · Cited by 280 · see citing works

DNA replication stress, genome instability and aging

Burhans, W. C., & Weinberger, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1059 · Cited by 279 · see citing works

Constraints on Energy Deposition and Target Size of Multiply Damaged Sites Associated with DNA Double-strand Breaks

Brenner, D. J., & Ward, J. F. (1992) · International Journal of Radiation Biology · doi:10.1080/09553009214551591 · Cited by 275 · see citing works

DNA double-strand breaks: their cellular and clinical impact?

Jeggo, P. A., & Löbrich, M. (2007) · Oncogene · doi:10.1038/sj.onc.1210868 · Cited by 272 · see citing works

Inhibition of Poly(ADP-Ribose) Polymerase Enhances Cell Death and Improves Tumor Growth Delay in Irradiated Lung Cancer Models

Albert, J. M., Cao, C., Kim, K. W., Willey, C. D., Geng, L., Xiao, D., Wang, H., Sandler, A. B., Johnson, D. H., Colevas, A. D., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2872 · Cited by 266 · see citing works

A PP4-Phosphatase Complex Dephosphorylates γ-H2AX Generated during DNA Replication

Chowdhury, D., Xu, X., Zhong, X., Ahmed, F., Zhong, J., Liao, J., Dykxhoorn, D. M., Weinstock, D. M., Pfeifer, G. P., & Lieberman, J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.016 · Cited by 248 · see citing works

ATM-dependent DNA Damage-independent Mitotic Phosphorylation of H2AX in Normally Growing Mammalian Cells

McManus, K. J., & Hendzel, M. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0065 · Cited by 242 · see citing works

DNA Double-Strand Breaks Form in Bystander Cells after Microbeam Irradiation of Three-dimensional Human Tissue Models

Sedelnikova, O. A., Nakamura, A., Kovalchuk, O., Koturbash, I., Mitchell, S., Marino, S. A., Brenner, D. J., & Bonner, W. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4442 · Cited by 234 · see citing works

Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair

Xie, A., Hartlerode, A. J., Stucki, M., Odate, S., Puget, N., Kwok, A., Nagaraju, G., Yan, C. T., Alt, F. W., Chen, J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.12.005 · Cited by 232 · see citing works

Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint‐blind DNA damage

Redon, C. E., Pilch, D. R., Rogakou, E. P., Orr, A. H., Lowndes, N. F., & Bonner, W. M. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor871 · Cited by 224 · see citing works

Leukocyte DNA Damage after Multi–Detector Row CT: A Quantitative Biomarker of Low-Level Radiation Exposure

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Cell Cycle-Dependent Expression of Phosphorylated Histone H2AX: Reduced Expression in Unirradiated but not X-Irradiated G1-Phase Cells

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