McCown, Thomas

Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors

Gray, S. J., Foti, S. B., Schwartz, J. W., Bachaboina, L., Taylor-Blake, B., Coleman, J., Ehlers, M. D., Zylka, M. J., McCown, T. J., & Samulski, R. J. (2011) · Human Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

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Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

Gray, S. J., Nagabhushan Kalburgi, S., McCown, T. J., & Jude Samulski, R. (2013) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

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Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles

Li, W., Asokan, A., Wu, Z., Van Dyke, T., DiPrimio, N., Johnson, J. S., Govindaswamy, L., Agbandje-McKenna, M., Leichtle, S., Eugene Redmond Jr, D., et al. (2008) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

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Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromised Blood–Brain Barrier (BBB)

Gray, S. J., Blake, B. L., Criswell, H. E., Nicolson, S. C., Samulski, R. J., & McCown, T. J. (2010) · Molecular Therapy

Virus-based gene therapy researchBarrier Structure and Function Studies

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Novel Transcriptional Regulatory Signals in the Adeno-Associated Virus Terminal Repeat A/D Junction Element

Haberman, R. P., McCown, T. J., & Samulski, R. J. (2000) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

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A Large U3 Deletion Causes Increased In Vivo Expression from a Nonintegrating Lentiviral Vector

Bayer, M., Kantor, B., Cockrell, A., Ma, H., Zeithaml, B., Li, X., McCown, T., & Kafri, T. (2008) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

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Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism

Powell, S. K., Khan, N., Parker, C. L., Samulski, R. J., Matsushima, G., Gray, S. J., & McCown, T. J. (2016) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

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Clinical Applications Involving CNS Gene Transfer

Kantor, B., McCown, T., Leone, P., & Gray, S. J. (2014) · Advances in Genetics

Virus-based gene therapy researchRNA Interference and Gene Delivery

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Notable Reduction in Illegitimate Integration Mediated by a PPT-deleted, Nonintegrating Lentiviral Vector

Kantor, B., Bayer, M., Ma, H., Samulski, J., Li, C., McCown, T., & Kafri, T. (2011) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

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Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

Mandel, R. J., Marmion, D. J., Kirik, D., Chu, Y., Heindel, C., McCown, T., Gray, S. J., & Kordower, J. H. (2017) · Acta Neuropathologica Communications

Parkinson's Disease Mechanisms and TreatmentsVirus-based gene therapy research

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N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase

Francis, J. S., Wojtas, I., Markov, V., Gray, S. J., McCown, T. J., Samulski, R. J., Bilaniuk, L. T., Wang, D.-J., De Vivo, D. C., Janson, C. G., et al. (2016) · Neurobiology of Disease

Metabolism and Genetic DisordersVirus-based gene therapy research

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Preclinical biodistribution, tropism, and efficacy of oligotropic AAV/Olig001 in a mouse model of congenital white matter disease

Francis, J. S., Markov, V., Wojtas, I. D., Gray, S., McCown, T., Samulski, R. J., Figueroa, M., & Leone, P. (2021) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRNA Interference and Gene Delivery

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Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivo

Zhou, X., Zeng, X., Fan, Z., Li, C., McCown, T., Samulski, R. J., & Xiao, X. (2008) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

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