Beach, David

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 5,218

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.

Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 3,650

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

Hannon, G. J., & Beach, D. (1994) · Nature

TGF-β signaling in diseasesCancer-related Molecular Pathways

Cited by 1,950

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 1,655

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D., & DePinho, R. A. (1996) · Cell

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 1,585

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 1,482

Radiation-induced cell cycle arrest compromised by p21 deficiency

Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., & Hannon, G. J. (1995) · Nature

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 1,242

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

Xiong, Y., Zhang, H., & Beach, D. (1992) · Cell

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 1,021

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

Alcorta, D. A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., & Barrett, J. C. (1996) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 1,008

Targeting CDK4 and CDK6: From Discovery to Therapy

Sherr, C. J., Beach, D., & Shapiro, G. I. (2016) · Cancer Discovery

Advanced Breast Cancer TherapiesCancer-related Molecular Pathways

Cited by 936

A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity

Hudson, J. D., Shoaibi, M. A., Maestro, R., Carnero, A., Hannon, G. J., & Beach, D. H. (1999) · The Journal of Experimental Medicine

Macrophage Migration Inhibitory FactorCancer-related Molecular Pathways

Cited by 649

Glycolytic Enzymes Can Modulate Cellular Life Span

Kondoh, H., Lleonart, M. E., Gil, J., Wang, J., Degan, P., Peters, G., Martinez, D., Carnero, A., & Beach, D. (2005) · Cancer Research

Telomeres, Telomerase, and SenescenceCancer, Hypoxia, and Metabolism

Cited by 647

twist is a potential oncogene that inhibits apoptosis

Maestro, R., Tos, A. P. D., Hamamori, Y., Krasnokutsky, S., Sartorelli, V., Kedes, L., Doglioni, C., Beach, D. H., & Hannon, G. J. (1999) · Genes & Development

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 516

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

Okamoto, K., & Beach, D. (1994) · The EMBO Journal

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 455

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

Burd, C. E., Sorrentino, J. A., Clark, K. S., Darr, D. B., Krishnamurthy, J., Deal, A. M., Bardeesy, N., Castrillon, D. H., Beach, D. H., & Sharpless, N. E. (2013) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 419

Polycomb CBX7 has a unifying role in cellular lifespan.

Gil, J., Bernard, D., Martínez, D., & Beach, D. (2004) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 341

A High Glycolytic Flux Supports the Proliferative Potential of Murine Embryonic Stem Cells

Kondoh, H., Lleonart, M. E., Nakashima, Y., Yokode, M., Tanaka, M., Bernard, D., Gil, J., & Beach, D. (2007) · Antioxidants & Redox Signaling

Cancer, Hypoxia, and MetabolismPluripotent Stem Cells Research

Cited by 325

Mutations associated with familial melanoma impair p16INK4 function

Ranade, K., Hussussian, C. J., Sikorski, R. S., Varmus, H. E., Goldstein, A. M., Tucker, M. A., Serrano, M., Hannon, G. J., Beach, D., & Dracopoli, N. C. (1995) · Nature Genetics

Cancer-related Molecular PathwaysCutaneous Melanoma Detection and Management

Cited by 280

Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21Waf1/Cip1

Borgdorff, V, Lleonart, M. E., Bishop, C. L., Fessart, D., Bergin, A. H., Overhoff, M. G., & Beach, D. H. (2010) · Oncogene

Telomeres, Telomerase, and SenescenceMicroRNA in disease regulation

Cited by 160

Cellular senescence mediated by p16INK4A-coupled miRNA pathways

Overhoff, M. G., Garbe, J. C., Koh, J., Stampfer, M. R., Beach, D. H., & Bishop, C. L. (2014) · Nucleic Acids Research

Telomeres, Telomerase, and SenescenceMicroRNA in disease regulation

Cited by 77

Ageing as developmental decay: insights from p16INK4a.

Martin, N., Beach, D., & Gil, J. (2014) · Trends in Molecular Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 76