Jefferson, Leonard S.

AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling

Bolster, D. R., Crozier, S. J., Kimball, S. R., & Jefferson, L. S. (2002) · Journal of Biological Chemistry

Muscle metabolism and nutritionMetabolism, Diabetes, and Cancer

Cited by 851

Signaling Pathways Involved in Translational Control of Protein Synthesis in Skeletal Muscle by Leucine

Anthony, J. C., Anthony, T. G., Kimball, S. R., & Jefferson, L. S. (2001) · The Journal of Nutrition

Muscle metabolism and nutritionRNA and protein synthesis mechanisms

Cited by 434

Oral leucine administration stimulates protein synthesis in rat skeletal muscle

Crozier, S. J., Kimball, S. R., Emmert, S. W., Anthony, J. C., & Jefferson, L. S. (2005) · The Journal of Nutrition

Muscle metabolism and nutritionRNA and protein synthesis mechanisms

Cited by 371

Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1

Wang, H., Kubica, N., Ellisen, L. W., Jefferson, L. S., & Kimball, S. R. (2006) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 262

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling

Dennis, M. D., Coleman, C. S., Berg, A., Jefferson, L. S., & Kimball, S. R. (2014) · Science Signaling

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 159

Glucagon Represses Signaling through the Mammalian Target of Rapamycin in Rat Liver by Activating AMP-activated Protein Kinase

Kimball, S. R., Siegfried, B. A., & Jefferson, L. S. (2004) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 133

Rapid Turnover of the mTOR Complex 1 (mTORC1) Repressor REDD1 and Activation of mTORC1 Signaling following Inhibition of Protein Synthesis

Kimball, S. R., Do, A. N. D., Kutzler, L., Cavener, D. R., & Jefferson, L. S. (2008) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 106

Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B

Kobayashi, H., Børsheim, E., Anthony, T. G., Traber, D. L., Badalamenti, J., Kimball, S. R., Jefferson, L. S., & Wolfe, R. R. (2003) · American Journal of Physiology-Endocrinology and Metabolism

Muscle metabolism and nutritionRNA and protein synthesis mechanisms

Cited by 103

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation

Kimball, S. R., Gordon, B. S., Moyer, J. E., Dennis, M. D., & Jefferson, L. S. (2016) · Cellular Signalling

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 97

Postprandial stimulation of muscle protein synthesis is independent of changes in insulin

Svanberg, E., Jefferson, L. S., Lundholm, K., & Kimball, S. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism

Muscle metabolism and nutritionRNA and protein synthesis mechanisms

Cited by 80