Biggs, Daniel

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

White, J. K., Gerdin, A.-K., Karp, N. A., Ryder, E., Buljan, M., Bussell, J. N., Salisbury, J., Clare, S., Ingham, N. J., Podrini, C., et al. (2013) · Cell

Genomics and Rare DiseasesAnimal Genetics and Reproduction

Cited by 509

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

Lakhal-Littleton, S., Wolna, M., Carr, C. A., Miller, J. J. J., Christian, H. C., Ball, V., Santos, A., Diaz, R., Biggs, D., Stillion, R., et al. (2015) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 234

Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

Hanssen, L. L. P., Kassouf, M. T., Oudelaar, A. M., Biggs, D., Preece, C., Downes, D. J., Gosden, M., Sharpe, J. A., Sloane-Stanley, J. A., Hughes, J. R., et al. (2017) · Nature Cell Biology

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 219

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

Lakhal-Littleton, S., Wolna, M., Chung, Y. J., Christian, H. C., Heather, L. C., Brescia, M., Ball, V., Diaz, R., Santos, A., Biggs, D., et al. (2016) · eLife

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 184

A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability

Davies, B., Brown, L. A., Cais, O., Watson, J., Clayton, A. J., Chang, V. T., Biggs, D., Preece, C., Hernandez-Pliego, P., Krohn, J., et al. (2017) · Human Molecular Genetics

Sleep and Wakefulness ResearchCircadian rhythm and melatonin

Cited by 48

Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia

Armitage, A. E., Lim, P. J., Frost, J. N., Pasricha, S.-R., Soilleux, E. J., Evans, E., Morovat, A., Santos, A., Diaz, R., Biggs, D., et al. (2016) · Journal of Innate Immunity

Iron Metabolism and DisordersImmune Response and Inflammation

Cited by 20