Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

Lakhal-Littleton, Samira; Wolna, Magda; Carr, Carolyn A.; Miller, Jack J. J.; Christian, Helen C.; Ball, Vicky; Santos, Ana; Diaz, Rebeca; Biggs, Daniel; Stillion, Richard; Holdship, Philip; Larner, Fiona; Tyler, Damian J.; Clarke, Kieran; Davies, Benjamin; Robbins, Peter A.

doi:10.1073/pnas.1422373112

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

Significance The iron-exporting protein ferroportin is recognized as central to systemic iron regulation, but its role in tissues other than those involved in iron handling is unknown. This study shows that ferroportin expression in cardiomyocytes is essential to intracellular iron homeostasis an…