Simpkins, James W.

Neuroprotective effects of estrogens: potential mechanisms of action

Green, P. S., & Simpkins, J. W. (2000) · International Journal of Developmental Neuroscience

Estrogen and related hormone effectsMenopause: Health Impacts and Treatments

Cited by 523

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Harrison, D. E., Strong, R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., et al. (2014) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 445

Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-Inducer

Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., et al. (2016) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 362

Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

Tesco, G., Koh, Y. H., Kang, E. L., Cameron, A. N., Das, S., Sena-Esteves, M., Hiltunen, M., Yang, S.-H., Zhong, Z., Shen, Y., et al. (2007) · Neuron

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 337

Expression of microRNA-34a in Alzheimer’s disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity

Sarkar, S., Jun, S., Rellick, S., Quintana, D. D., Cavendish, J. Z., & Simpkins, J. W. (2016) · Brain Research

MicroRNA in disease regulationAlzheimer's disease research and treatments

Cited by 209

Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier

Doll, D. N., Hu, H., Sun, J., Lewis, S. E., Simpkins, J. W., & Ren, X. (2015) · Stroke

Barrier Structure and Function StudiesAcute Ischemic Stroke Management

Cited by 202

Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats

Wen, Y., Yang, S.-H., Liu, R., Perez, E. J., Brun-Zinkernagel, A. M., Koulen, P., & Simpkins, J. W. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 162

Over-expression of miR-34a induces rapid cognitive impairment and Alzheimer’s disease-like pathology

Sarkar, S., Engler-Chiurazzi, E. B., Cavendish, J. Z., Povroznik, J. M., Russell, A. E., Quintana, D. D., Mathers, P. H., & Simpkins, J. W. (2019) · Brain Research

Alzheimer's disease research and treatmentsMicroRNA in disease regulation

Cited by 91

Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner

Porter, K. N., Sarkar, S. N., Dakhlallah, D. A., Vannoy, M. E., Quintana, D. D., & Simpkins, J. W. (2020) · Frontiers in Aging Neuroscience

Alzheimer's disease research and treatmentsProtease and Inhibitor Mechanisms

Cited by 17