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Cited by 86

Over-expression of miR-34a induces rapid cognitive impairment and Alzheimer’s disease-like pathology

Sarkar, S., Engler-Chiurazzi, E.B., Cavendish, J.Z., Povroznik, J.M., Russell, A.E., Quintana, D.D., Mathers, P.H., Simpkins, J.W.·2019·Brain Research
DOI 10.1016/j.brainres.2019.146327PMC PMC7014559
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  • Through repression of TREM2 and SIRT1, miR-34a lowers microglial capacity to clear Aβ and promotes a sustained inflammatory phenotype, contributing to synaptic and metabolic decline.

    “Through this repression, miR-34a lowers microglial capacity to clear Aβ and promotes a sustained inflammatory phenotype, contributing to synaptic and metabolic decline (Sarkar et al., 2016; Sarkar et al., 2019).”

    From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Sarkar et al., 2019

    The Results report reduced SIRT1 protein in miR-34a-overexpressing mice, and the Discussion links SIRT1 inhibition to disrupted energy metabolism and inflammatory responses, alongside impaired synaptic function. But the cited paper does not establish TREM2 repression, reduced microglial Aβ clearance, or a sustained microglial inflammatory phenotype; its reported Aβ findings concern APP processing and predominantly intracellular Aβ. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • MiR-34a is strongly induced in AD and directly represses TREM2 and SIRT1, both essential for microglial metabolic fitness, phagocytosis, and transition into the disease-associated microglial (DAM) state.

    “MiR-34a is also strongly induced in AD and exerts multifaceted pathogenic effects. It directly represses TREM2 and SIRT1, both essential for microglial metabolic fitness, phagocytosis, and transition into the disease-associated microglial (DAM) state (Bhattacharjee et al., 2014; Sarkar et al., 2016; Sarkar et al., 2019).”

    From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Sarkar et al., 2019

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Research works printed but not linked: 46

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Authors
Sarkar, S., Engler-Chiurazzi, E. B., Cavendish, J. Z., Povroznik, J. M., Russell, A. E., Quintana, D. D., Mathers, P. H., & Simpkins, J. W.
Venue
Brain Research
Publisher
Elsevier BV
Published
2019-10
Volume
1721
Pages
146327
ISSN
0006-8993
DOI
10.1016/j.brainres.2019.146327
PMC
PMC7014559
Cited by
86
References
10
Language
en
Licence
Funders
National Institutes of Health (P01 AG027956, P20 GM109098, T32 AG052375, U54 GM10494243T)

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