Larsen, P. Reed

Substrate-Induced Down-Regulation of Human Type 2 Deiodinase (hD2) Is Mediated through Proteasomal Degradation and Requires Interaction with the Enzyme’s Active Center1

Steinsapir, J., Bianco, A. C., Buettner, C., Harney, J., & Larsen, P. R. (2000) · Endocrinology

Thyroid Disorders and TreatmentsUbiquitin and proteasome pathways

Cited by 109

Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes

Steinsapir, J., Harney, J., & Larsen, P. R. (1998) · Journal of Clinical Investigation

Thyroid Disorders and TreatmentsUbiquitin and proteasome pathways

Cited by 102

Studies of the Hormonal Regulation of Type 2 5′-Iodothyronine Deiodinase Messenger Ribonucleic Acid in Pituitary Tumor Cells Using Semiquantitative Reverse Transcription-Polymerase Chain Reaction**This work was supported by NIH Grant DK-36256.

Kim, S.-W., Harney, J. W., & Larsen, P. R. (1998) · Endocrinology

Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

Cited by 86

Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency

Peeters, R., Fekete, C., Goncalves, C., Legradi, G., Tu, H. M., Harney, J. W., Bianco, A. C., Lechan, R. M., & Larsen, P. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism

Thyroid Disorders and TreatmentsChemical Analysis and Environmental Impact

Cited by 79

Further Characterization of Thyroid Hormone Response Elements in the Human Type 1 Iodothyronine Deiodinase Gene1

Zhang, C.-Y., Kim, S., Harney, J. W., & Larsen, P. R. (1998) · Endocrinology

Thyroid Disorders and TreatmentsEstrogen and related hormone effects

Cited by 72

Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors

Maynard, M. A., Marino-Enriquez, A., Fletcher, J. A., Dorfman, D. M., Raut, C. P., Yassa, L., Guo, C., Wang, Y., Dorfman, C., Feldman, H. A., et al. (2014) · New England Journal of Medicine

Gastrointestinal Tumor Research and TreatmentThyroid Disorders and Treatments

Cited by 70

The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1)

Gereben, B., Salvatore, D., Harney, J. W., Tu, H. M., & Larsen, P. R. (2001) · Molecular Endocrinology

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 70

Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse

Kádár, A., Sánchez, E., Wittmann, G., Singru, P. S., Füzesi, T., Marsili, A., Larsen, P. R., Liposits, Z., Lechan, R. M., & Fekete, C. (2010) · Journal of Comparative Neurology

Hypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

Cited by 66

Mice with Impaired Extrathyroidal Thyroxine to 3,5,3′-Triiodothyronine Conversion Maintain Normal Serum 3,5,3′-Triiodothyronine Concentrations

Christoffolete, M. A., Arrojo e Drigo, R., Gazoni, F., Tente, S. M., Goncalves, V., Amorim, B. S., Larsen, P. R., Bianco, A. C., & Zavacki, A. M. (2007) · Endocrinology

Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

Cited by 62

DARPP-32 and CREB are present in type 2 iodothyronine deiodinase-producing tanycytes: implications for the regulation of type 2 deiodinase activity

Fekete, C., Mihály, E., Herscovici, S., Salas, J., Tu, H., Larsen, P. R., & Lechan, R. M. (2000) · Brain Research

Thyroid Disorders and TreatmentsRegulation of Appetite and Obesity

Cited by 38

Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase

Marsili, A., Sanchez, E., Singru, P., Harney, J. W., Zavacki, A. M., Lechan, R. M., & Larsen, P. R. (2011) · Journal of Endocrinology

Thyroid Disorders and TreatmentsNeuropeptides and Animal Physiology

Cited by 27