Tak, Paul P.

NF-κB: a key role in inflammatory diseases

Tak, P. P., & Firestein, G. S. (2001) · Journal of Clinical Investigation

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 3,918

Genetics of rheumatoid arthritis contributes to biology and drug discovery

the RACI consortium, Okada, Y., the GARNET consortium, Wu, D., Trynka, G., Raj, T., Terao, C., Ikari, K., Kochi, Y., Ohmura, K., et al. (2014) · Nature

Rheumatoid Arthritis Research and TherapiesGenetic Associations and Epidemiology

Cited by 2,310

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

BIRAC Consortium, Stahl, E. A., YEAR Consortium, Raychaudhuri, S., Remmers, E. F., Xie, G., Eyre, S., Thomson, B. P., Li, Y., Kurreeman, F. A. S., et al. (2010) · Nature Genetics

Rheumatoid Arthritis Research and TherapiesGenetic Associations and Epidemiology

Cited by 1,253

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

Koopman, F. A., Chavan, S. S., Miljko, S., Grazio, S., Sokolovic, S., Schuurman, P. R., Mehta, A. D., Levine, Y. A., Faltys, M., Zitnik, R., et al. (2016) · Proceedings of the National Academy of Sciences

Vagus Nerve Stimulation ResearchRheumatoid Arthritis Research and Therapies

Cited by 1,024

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

Hueber, W., Patel, D. D., Dryja, T., Wright, A. M., Koroleva, I., Bruin, G., Antoni, C., Draelos, Z., Gold, M. H., the Psoriasis Study Group, et al. (2010) · Science Translational Medicine

Psoriasis: Treatment and PathogenesisRheumatoid Arthritis Research and Therapies

Cited by 860

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

Ambarus, C. A., Krausz, S., van Eijk, M., Hamann, J., Radstake, T. R. D. J., Reedquist, K. A., Tak, P. P., & Baeten, D. L. P. (2012) · Journal of Immunological Methods

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 411

Therapeutic options for targeting inflammatory osteoarthritis pain

Conaghan, P. G., Cook, A. D., Hamilton, J. A., & Tak, P. P. (2019) · Nature Reviews Rheumatology

Osteoarthritis Treatment and MechanismsPain Mechanisms and Treatments

Cited by 405

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

McInnes, I. B., Sieper, J., Braun, J., Emery, P., van der Heijde, D., Isaacs, J. D., Dahmen, G., Wollenhaupt, J., Schulze-Koops, H., Kogan, J., et al. (2014) · Annals of the Rheumatic Diseases

Spondyloarthritis Studies and TreatmentsPsoriasis: Treatment and Pathogenesis

Cited by 343

Receptor activator NF-κB ligand (RANKL) expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathy, osteoarthritis, and from normal patients: semiquantitative and quantitative analysis.

Crotti, T. N., Smith, M. D., Weedon, H., Ahern, M. J., Findlay, D. M., Kraan, M., Tak, P. P., & Haynes, D. R. (2002) · Annals of the Rheumatic Diseases

Rheumatoid Arthritis Research and TherapiesNatural Compounds in Disease Treatment

Cited by 186

Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis

Kasperkovitz, P. V., Timmer, T. C. G., Smeets, T. J., Verbeet, N. L., Tak, P. P., van baarsen, L. G. M., Baltus, B., Huizinga, T. W. J., Pieterman, E., Fero, M., et al. (2005) · Arthritis & Rheumatism

Rheumatoid Arthritis Research and TherapiesAutoimmune and Inflammatory Disorders Research

Cited by 148

Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue

Mingozzi, F., Chen, Y., Edmonson, S. C., Zhou, S., Thurlings, R. M., Tak, P. P., High, K. A., & Vervoordeldonk, M. J. (2013) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 138

Empty capsids and macrophage inhibition/depletion increase rAAV transgene expression in joints of both healthy and arthritic mice

Aalbers, C. J., Broekstra, N., van Geldorp, M., Kramer, E., Ramiro, S., Tak, P. P., Vervoordeldonk, M. J., & Finn, J. D. (2017) · Human Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 16